Tác động của các họa chất liên quan đến mầm bệnh vi khuẩn và virus (PAMPs) lên các bơm kháng đa thuốc (MDR) trong các tế bào nội mô não của hàng rào máu-não đang phát triển ở người

citation_journal_title=Fluids Barriers CNS; citation_title=A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity; citation_author=H Kadry, B Noorani, L Cucullo; citation_volume=17; citation_publication_date=2020; citation_pages=69; citation_doi=10.1186/s12987-020-00230-3; citation_id=CR1 citation_journal_title=NeuroRX; citation_title=The blood-brain barrier: bottleneck in brain drug development; citation_author=WM Pardridge; citation_volume=2; citation_publication_date=2005; citation_pages=3-14; citation_doi=10.1602/neurorx.2.1.3; citation_id=CR2 Bloise E, Matthews SG. Multidrug Resistance P-Glycoprotein (P-gp), Glucocorticoids, and the Stress Response. Stress Physiol Biochem Pathol . Elsevier; 2019. p. 227–41. citation_journal_title=Cell Mol Life Sci CMLS; citation_title=ATP-binding cassette (ABC) drug transporters in the developing blood-brain barrier: role in fetal brain protection; citation_author=ME Eng, GE Imperio, E Bloise, SG Matthews; citation_volume=79; citation_publication_date=2022; citation_pages=415; citation_doi=10.1007/s00018-022-04432-w; citation_id=CR4 citation_journal_title=Epilepsia; citation_title=Overview and introduction: the blood-brain barrier in health and disease: blood-brain barrier in health and disease; citation_author=NJ Abbott, A Friedman; citation_volume=53; citation_publication_date=2012; citation_pages=1-6; citation_doi=10.1111/j.1528-1167.2012.03696.x; citation_id=CR5 citation_journal_title=Brain Res; citation_title=Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders; citation_author=H Qosa, DS Miller, P Pasinelli, D Trotti; citation_volume=1628; citation_publication_date=2015; citation_pages=298-316; citation_doi=10.1016/j.brainres.2015.07.005; citation_id=CR6 citation_journal_title=Hum Reprod Update; citation_title=ATP-binding cassette transporters in reproduction: a new frontier; citation_author=E Bloise, TM Ortiga-Carvalho, FM Reis, SJ Lye, W Gibb, SG Matthews; citation_publication_date=2015; citation_doi=10.1093/humupd/dmv049; citation_id=CR7 citation_journal_title=Trends Pharmacol Sci; citation_title=Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier; citation_author=DS Miller; citation_volume=31; citation_publication_date=2010; citation_pages=246-54; citation_doi=10.1016/j.tips.2010.03.003; citation_id=CR8 citation_journal_title=Cells; citation_title=Functional expression of multidrug-resistance (MDR) transporters in developing human fetal brain endothelial cells; citation_author=P Lye, E Bloise, GE Imperio, D Chitayat, SG Matthews; citation_volume=11; citation_publication_date=2022; citation_pages=2259; citation_doi=10.3390/cells11142259; citation_id=CR9 citation_journal_title=Curr Drug Targets; citation_title=Significance and mechanisms of P-glycoprotein in central nervous system diseases; citation_author=L Huang, B Li, X Li, G Liu, R Liu, J Guo; citation_volume=20; citation_publication_date=2019; citation_pages=1141-55; citation_doi=10.2174/1389450120666190308144448; citation_id=CR10 citation_journal_title=Tissue Barriers.; citation_title=Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells; citation_author=GI Eustaquio, P Lye, E Bloise, SG Matthews; citation_volume=9; citation_publication_date=2021; citation_pages=1860616; citation_doi=10.1080/21688370.2020.1860616; citation_id=CR11 citation_journal_title=PLoS ONE; citation_title=Pro-inflammatory cytokine regulation of P-glycoprotein in the developing blood-brain barrier; citation_author=M Iqbal, HL Ho, S Petropoulos, VG Moisiadis, W Gibb, SG Matthews; citation_volume=7; citation_publication_date=2012; citation_pages=e43022; citation_doi=10.1371/journal.pone.0043022; citation_id=CR12 citation_journal_title=Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol; citation_title=Acute effects of viral exposure on P-glycoprotein function in the mouse fetal blood-brain barrier; citation_author=E Bloise, S Petropoulos, M Iqbal, A Kostaki, TM Ortiga-Carvalho, W Gibb; citation_volume=41; citation_publication_date=2017; citation_pages=1044-1050; citation_doi=10.1159/000461569; citation_id=CR13 citation_journal_title=J Nutr Biochem; citation_title=Adaptation of the gut holobiont to malnutrition during mouse pregnancy depends on the type of nutritional adversity; citation_author=KL Connor, E Bloise, TZ DeSantis, SJ Lye; citation_publication_date=2022; citation_doi=10.1016/j.jnutbio.2022.109172; citation_id=CR14 citation_journal_title=Sci Rep; citation_title=Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor; citation_author=KN Fontes, MW Reginatto, NL Silva, CBV Andrade, FF Bloise, VRS Monteiro; citation_volume=9; citation_publication_date=2019; citation_pages=11488; citation_doi=10.1038/s41598-019-47865-3; citation_id=CR15 citation_journal_title=Sci Rep; citation_title=Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction; citation_author=VRS Monteiro, CBV Andrade, HR Gomes, MW Reginatto, GE Império, KN Fontes; citation_volume=12; citation_publication_date=2022; citation_pages=10262; citation_doi=10.1038/s41598-022-14248-0; citation_id=CR16 citation_journal_title=Front Immunol; citation_title=ZIKV disrupts placental ultrastructure and drug transporter expression in mice; citation_author=CBV Andrade, VRS Monteiro, SVA Coelho, HR Gomes, RPC Sousa, VMO Nascimento; citation_volume=12; citation_publication_date=2021; citation_pages=680246; citation_doi=10.3389/fimmu.2021.680246/full; citation_id=CR17 citation_journal_title=Front Microbiol; citation_title=Effect of sublethal prenatal endotoxaemia on murine placental transport systems and lipid homeostasis; citation_author=MW Reginatto, KN Fontes, VRS Monteiro, NL Silva, CBV Andrade, HR Gomes; citation_volume=12; citation_publication_date=2021; citation_pages=706499; citation_doi=10.3389/fmicb.2021.706499/full; citation_id=CR18 citation_journal_title=Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol; citation_title=Chorioamnionitis induces a specific signature of placental ABC transporters associated with an increase of miR-331–5p in the human preterm placenta; citation_author=GE Imperio, E Bloise, M Javam, P Lye, A Constantinof, C Dunk; citation_volume=45; citation_publication_date=2018; citation_pages=591-604; citation_doi=10.1159/000487100; citation_id=CR19 citation_journal_title=Toxicol Appl Pharmacol; citation_title=Infection and disruption of placental multidrug resistance (MDR) transporters: Implications for fetal drug exposure; citation_author=CBV Andrade, LVA Lopes, TM Ortiga-Carvalho, SG Matthews, E Bloise; citation_volume=459; citation_publication_date=2023; citation_pages=116344; citation_doi=10.1016/j.taap.2022.116344; citation_id=CR20 citation_journal_title=J Cell Mol Med; citation_title=Malaria in pregnancy regulates P-glycoprotein (P-gp/ Abcb1a ) and ABCA1 efflux transporters in the mouse visceral yolk sac; citation_author=LM Martinelli, KN Fontes, MW Reginatto, CBV Andrade, VRS Monteiro, HR Gomes; citation_volume=24; citation_publication_date=2020; citation_pages=10636-47; citation_doi=10.1111/jcmm.15682; citation_id=CR21 citation_journal_title=Reprod Sci; citation_title=Translational comparison of the human and mouse yolk sac development and function; citation_author=LM Martinelli, A Carucci, VJH Payano, KL Connor, E Bloise; citation_publication_date=2022; citation_doi=10.1007/s43032-022-00872-8; citation_id=CR22 citation_journal_title=Reprod Toxicol; citation_title=Breast cancer resistance protein (Bcrp/Abcg2) is selectively modulated by lipopolysaccharide (LPS) in the mouse yolk sac; citation_author=LM Martinelli, MW Reginatto, KN Fontes, CBV Andrade, VRS Monteiro, HR Gomes; citation_volume=98; citation_publication_date=2020; citation_pages=82-91; citation_doi=10.1016/j.reprotox.2020.09.001; citation_id=CR23 citation_journal_title=Handb Clin Neurol; citation_title=Neurologic infections during pregnancy; citation_author=AM Curcio, P Shekhawat, AS Reynolds, KT Thakur; citation_volume=172; citation_publication_date=2020; citation_pages=79-104; citation_doi=10.1016/B978-0-444-64240-0.00005-2; citation_id=CR24 citation_journal_title=Eur J Obstet Gynecol Reprod Biol; citation_title=Term histologic chorioamnionitis: a heterogeneous condition; citation_author=N Conti, M Torricelli, C Voltolini, S Vannuccini, VL Clifton, E Bloise; citation_volume=188; citation_publication_date=2015; citation_pages=34-8; citation_doi=10.1016/j.ejogrb.2015.02.034; citation_id=CR25 citation_journal_title=Nat Rev Microbiol; citation_title=Infections at the maternal–fetal interface: an overview of pathogenesis and defence; citation_author=CJ Megli, CB Coyne; citation_volume=20; citation_publication_date=2022; citation_pages=67-82; citation_doi=10.1038/s41579-021-00610-y; citation_id=CR26 citation_journal_title=Front Neurosci; citation_title=Perinatal brain injury as a consequence of preterm birth and intrauterine inflammation: designing targeted stem cell therapies; citation_author=MCB Paton, CA McDonald, BJ Allison, MC Fahey, G Jenkin, SL Miller; citation_publication_date=2017; citation_doi=10.3389/fnins.2017.00200/full; citation_id=CR27 citation_journal_title=Infect Immun; citation_title=Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10; citation_author=SH Huang, C Wass, Q Fu, NV Prasadarao, M Stins, KS Kim; citation_volume=63; citation_publication_date=1995; citation_pages=4470-5; citation_doi=10.1128/iai.63.11.4470-4475.1995; citation_id=CR28 citation_journal_title=Infect Immun; citation_title=Escherichia coli translocation at the blood-brain barrier; citation_author=KS Kim; citation_volume=69; citation_publication_date=2001; citation_pages=5217-22; citation_doi=10.1128/IAI.69.9.5217-5222.2001; citation_id=CR29 citation_journal_title=J Neurosci; citation_title=Neonatal E. Coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron; citation_author=JC Lieblein-Boff, DB McKim, DT Shea, P Wei, Z Deng, C Sawicki; citation_volume=33; citation_publication_date=2013; citation_pages=16334-45; citation_doi=10.1523/JNEUROSCI.0708-13.2013; citation_id=CR30 citation_journal_title=Neonatology; citation_title=Ureaplasma-driven neuroinflammation in neonates: assembling the puzzle pieces; citation_author=C Silwedel, CP Speer, C Härtel, K Glaser; citation_volume=117; citation_publication_date=2020; citation_pages=665-72; citation_doi=10.1159/000512019; citation_id=CR31 citation_journal_title=Semin Fetal Neonatal Med; citation_title=Intrauterine infection and preterm labor; citation_author=V Agrawal, E Hirsch; citation_volume=17; citation_publication_date=2012; citation_pages=12-9; citation_doi=10.1016/j.siny.2011.09.001; citation_id=CR32 citation_journal_title=Nutrients; citation_title=Fetal brain damage during maternal COVID-19: emerging hypothesis, mechanism, and possible mitigation through maternal-targeted nutritional supplementation; citation_author=C Germano, A Messina, E Tavella, R Vitale, V Avellis, M Barboni; citation_volume=14; citation_publication_date=2022; citation_pages=3303; citation_doi=10.3390/nu14163303; citation_id=CR33 citation_journal_title=Mol Pharmacol; citation_title=Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-α and lipopolysaccharide; citation_author=AMS Hartz, B Bauer, G Fricker, DS Miller; citation_volume=69; citation_publication_date=2006; citation_pages=462-70; citation_doi=10.1124/mol.105.017954; citation_id=CR34 citation_journal_title=Cells; citation_title=Breast cancer resistance protein (BCRP/ABCG2) inhibits extra villous trophoblast migration: the impact of bacterial and viral infection; citation_author=P Lye, E Bloise, L Nadeem, C Peng, W Gibb, TM Ortiga-Carvalho; citation_volume=8; citation_publication_date=2019; citation_pages=E1150; citation_doi=10.3390/cells8101150; citation_id=CR35 citation_journal_title=Biol Reprod; citation_title=Viral Single stranded RNA induces a trophoblast pro-inflammatory and antiviral response in a TLR8-dependent and -independent manner1; citation_author=JA Potter, M Garg, S Girard, VM Abrahams; citation_publication_date=2015; citation_doi=10.1095/biolreprod.114.124032; citation_id=CR36 citation_journal_title=Am J Pathol; citation_title=Impact of bacterial and viral challenge on multidrug resistance in first- and third-trimester human placenta; citation_author=P Lye, E Bloise, M Javam, W Gibb, SJ Lye, SG Matthews; citation_volume=185; citation_publication_date=2015; citation_pages=1666-1675; citation_doi=10.1016/j.ajpath.2015.02.013; citation_id=CR37 citation_journal_title=J Cell Sci; citation_title=Cytoplasmic mislocalization of p27 and CDK2 mediates the anti-migratory and anti-proliferative effects of Nodal in human trophoblast cells; citation_author=L Nadeem, J Brkic, YF Chen, T Bui, S Munir, C Peng; citation_volume=126; citation_publication_date=2013; citation_pages=445-53; citation_doi=10.1242/jcs.110197; citation_id=CR38 citation_journal_title=J Cell Mol Med; citation_title=Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta; citation_author=P Lye, E Bloise, L Nadeem, W Gibb, SJ Lye, SG Matthews; citation_volume=22; citation_publication_date=2018; citation_pages=3652-3660; citation_doi=10.1111/jcmm.13646; citation_id=CR39 citation_journal_title=FASEB J Off Publ Fed Am Soc Exp Biol; citation_title=Fetal glucocorticoid exposure leads to sex-specific changes in drug-transporter function at the blood-brain barrier in juvenile guinea pigs; citation_author=ME Eng, E Bloise, SG Matthews; citation_volume=36; citation_publication_date=2022; citation_pages=e22245; citation_id=CR40 citation_journal_title=J Cell Mol Med; citation_title=Gestational age-dependent gene expression profiling of ATP-binding cassette transporters in the healthy human placenta; citation_author=GE Imperio, M Javam, P Lye, A Constantinof, CE Dunk, FM Reis; citation_volume=23; citation_publication_date=2019; citation_pages=610-8; citation_doi=10.1111/jcmm.13966; citation_id=CR41 citation_journal_title=Physiol Rev.; citation_title=Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system; citation_author=B Sarkadi, L Homolya, G Szakács, A Váradi; citation_volume=86; citation_publication_date=2006; citation_pages=1179-236; citation_doi=10.1152/physrev.00037.2005; citation_id=CR42 citation_journal_title=Cytokine; citation_title=LPS/TLR4 signal transduction pathway; citation_author=Y-C Lu, W-C Yeh, PS Ohashi; citation_volume=42; citation_publication_date=2008; citation_pages=145-51; citation_doi=10.1016/j.cyto.2008.01.006; citation_id=CR43 citation_journal_title=Mol Pharmacol; citation_title=Pim-1 kinase protects p-glycoprotein from degradation and enables its glycosylation and cell surface expression; citation_author=Y Xie, M Burcu, DE Linn, Y Qiu, MR Baer; citation_volume=78; citation_publication_date=2010; citation_pages=310-8; citation_doi=10.1124/mol.109.061713; citation_id=CR44 citation_journal_title=J Biol Chem; citation_title=Intestinal breast cancer resistance protein (BCRP) requires janus kinase 3 activity for drug efflux and barrier functions in obesity; citation_author=J Mishra, R Simonsen, N Kumar; citation_volume=294; citation_publication_date=2019; citation_pages=18337-48; citation_doi=10.1074/jbc.RA119.007758; citation_id=CR45 citation_journal_title=Cancer Chemother Pharmacol; citation_title=Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2); citation_author=K Mohrmann, MAJ Eijndhoven, AH Schinkel, JHM Schellens; citation_volume=56; citation_publication_date=2005; citation_pages=344-50; citation_doi=10.1007/s00280-005-1004-5; citation_id=CR46 citation_journal_title=Biochemistry.; citation_title=N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane; citation_author=NK Diop, CA Hrycyna; citation_volume=44; citation_publication_date=2005; citation_pages=5420-9; citation_doi=10.1021/bi0479858; citation_id=CR47 citation_journal_title=Mol Pharmacol; citation_title=Regulation of the stability of P-glycoprotein by ubiquitination; citation_author=Z Zhang, J-Y Wu, WN Hait, J-M Yang; citation_volume=66; citation_publication_date=2004; citation_pages=395-403; citation_doi=10.1124/mol.104.001966; citation_id=CR48 citation_journal_title=Proc Natl Acad Sci; citation_title=The dsRNA binding site of human toll-like receptor 3; citation_author=JK Bell, J Askins, PR Hall, DR Davies, DM Segal; citation_volume=103; citation_publication_date=2006; citation_pages=8792-7; citation_doi=10.1073/pnas.0603245103; citation_id=CR49 citation_journal_title=Immunity; citation_title=Structural analysis reveals that toll-like receptor 7 is a dual receptor for guanosine and single-stranded RNA; citation_author=Z Zhang, U Ohto, T Shibata, E Krayukhina, M Taoka, Y Yamauchi; citation_volume=45; citation_publication_date=2016; citation_pages=737-48; citation_doi=10.1016/j.immuni.2016.09.011; citation_id=CR50 citation_journal_title=Cancer Res; citation_title=Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier; citation_author=S Cisternino, C Mercier, F Bourasset, F Roux, J-M Scherrmann; citation_volume=64; citation_publication_date=2004; citation_pages=3296-301; citation_doi=10.1158/0008-5472.CAN-03-2033; citation_id=CR51 citation_journal_title=J Cell Mol Med; citation_title=P-glycoprotein (P-gp)/ABCB1 plays a functional role in extravillous trophoblast (EVT) invasion and is decreased in the pre-eclamptic placenta; citation_author=CE Dunk, JJ Pappas, P Lye, M Kibschull, M Javam, E Bloise; citation_volume=22; citation_publication_date=2018; citation_pages=5378-5393; citation_doi=10.1111/jcmm.13810; citation_id=CR52 citation_journal_title=Cell; citation_title=Toll-like receptors and the control of immunity; citation_author=KA Fitzgerald, JC Kagan; citation_volume=180; citation_publication_date=2020; citation_pages=1044-66; citation_doi=10.1016/j.cell.2020.02.041; citation_id=CR53 citation_journal_title=Immunology; citation_title=Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells; citation_author=TM Schaefer, K Desouza, JV Fahey, KW Beagley, CR Wira; citation_volume=112; citation_publication_date=2004; citation_pages=428-36; citation_doi=10.1111/j.1365-2567.2004.01898.x; citation_id=CR54 citation_journal_title=Neurology; citation_title=TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk; citation_author=HK Lim, M Seppanen, T Hautala, MJ Ciancanelli, Y Itan, FG Lafaille; citation_volume=83; citation_publication_date=2014; citation_pages=1888-97; citation_doi=10.1212/WNL.0000000000000999; citation_id=CR55 citation_journal_title=Virol J; citation_title=Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways; citation_author=W Zheng, Q Xu, Y Zhang, E Xiaofei, W Gao, M Zhang; citation_volume=17; citation_publication_date=2020; citation_pages=192; citation_doi=10.1186/s12985-020-01463-2; citation_id=CR56 citation_journal_title=Microorganisms; citation_title=TLR3 and TLR7 RNA sensor activation during SARS-CoV-2 infection; citation_author=D Bortolotti, V Gentili, S Rizzo, G Schiuma, S Beltrami, G Strazzabosco; citation_volume=9; citation_publication_date=2021; citation_pages=1820; citation_doi=10.3390/microorganisms9091820; citation_id=CR57 citation_journal_title=JCI Insight; citation_title=SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8; citation_author=V Salvi, HO Nguyen, F Sozio, T Schioppa, C Gaudenzi, M Laffranchi; citation_volume=6; citation_publication_date=2021; citation_pages=e150542; citation_doi=10.1172/jci.insight.150542; citation_id=CR58 citation_journal_title=Virology; citation_title=Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin; citation_author=B Vanwalscappel, T Tada, NR Landau; citation_volume=522; citation_publication_date=2018; citation_pages=199-208; citation_doi=10.1016/j.virol.2018.07.014; citation_id=CR59 citation_journal_title=Int J Infect Dis; citation_title=Teratogenic viral infections of the fetal central nervous system in animals: timing and pathogen genetics are critical; citation_author=NJ Maclachlan; citation_volume=53; citation_publication_date=2016; citation_pages=6; citation_doi=10.1016/j.ijid.2016.11.018; citation_id=CR60 citation_journal_title=Sci Rep; citation_title=The functional and inflammatory response of brain endothelial cells to toll-like receptor agonists; citation_author=RH Johnson, DT Kho, O’SJ Carroll, CE Angel, ES Graham; citation_volume=8; citation_publication_date=2018; citation_pages=10102; citation_doi=10.1038/s41598-018-28518-3; citation_id=CR61 citation_journal_title=PLoS ONE; citation_title=Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects; citation_author=E Bloise, M Bhuiyan, MC Audette, S Petropoulos, M Javam, W Gibb; citation_volume=8; citation_publication_date=2013; citation_pages=e65728; citation_doi=10.1371/journal.pone.0065728; citation_id=CR62 citation_journal_title=Cells; citation_title=ACE2 is expressed in immune cells that infiltrate the placenta in infection-associated preterm birth; citation_author=P Lye, CE Dunk, J Zhang, Y Wei, J Nakpu, H Hamada; citation_volume=10; citation_publication_date=2021; citation_pages=1724; citation_doi=10.3390/cells10071724; citation_id=CR63 citation_journal_title=J Neurochem; citation_title=Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro; citation_author=M Wedel-Parlow, P Wölte, H-J Galla; citation_volume=111; citation_publication_date=2009; citation_pages=111-8; citation_doi=10.1111/j.1471-4159.2009.06305.x; citation_id=CR64 citation_journal_title=Adv Nutr; citation_title=The importance of maternal folate status for brain development and function of offspring; citation_author=EFG Naninck, PC Stijger, EM Brouwer-Brolsma; citation_volume=10; citation_publication_date=2019; citation_pages=502-19; citation_doi=10.1093/advances/nmy120; citation_id=CR65 citation_journal_title=Open Biol; citation_title=Sphingolipids: membrane microdomains in brain development, function and neurological diseases; citation_author=ASB Olsen, NJ Færgeman; citation_volume=7; citation_publication_date=2017; citation_pages=170069; citation_doi=10.1098/rsob.170069; citation_id=CR66 citation_journal_title=Biochem Biophys Res Commun; citation_title=Testosterone and androstenedione are endogenous substrates of P-glycoprotein; citation_author=K Yano, S Seto, H Kamioka, K Mizoi, T Ogihara; citation_volume=520; citation_publication_date=2019; citation_pages=166-70; citation_doi=10.1016/j.bbrc.2019.09.067; citation_id=CR67 citation_journal_title=Pediatr Res; citation_title=The ontogeny of P-glycoprotein in the developing human blood-brain barrier: implication for opioid toxicity in neonates; citation_author=J Lam, S Baello, M Iqbal, LE Kelly, PT Shannon, D Chitayat; citation_volume=78; citation_publication_date=2015; citation_pages=417-421; citation_doi=10.1038/pr.2015.119; citation_id=CR68 citation_journal_title=Placenta; citation_title=Effect of oxygen on multidrug resistance in the first trimester human placenta; citation_author=P Lye, E Bloise, C Dunk, M Javam, W Gibb, SJ Lye; citation_volume=34; citation_publication_date=2013; citation_pages=817-823; citation_doi=10.1016/j.placenta.2013.05.010; citation_id=CR69 citation_journal_title=FEBS J; citation_title=P-glycoprotein: a role in the export of amyloid-β in Alzheimer’s disease?; citation_author=AB Chai, GKF Leung, R Callaghan, IC Gelissen; citation_volume=287; citation_publication_date=2020; citation_pages=612-25; citation_doi=10.1111/febs.15148; citation_id=CR70 citation_journal_title=Hum Mol Genet; citation_title=Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1 -/- lethal mouse model of neonatal hyperbilirubinemia; citation_author=L Bočkor, G Bortolussi, S Vodret, A Iaconcig, J Jašprová, J Zelenka; citation_publication_date=2016; citation_doi=10.1093/hmg/ddw375; citation_id=CR71 citation_journal_title=NeuroToxicol; citation_title=Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring; citation_author=WW Wilson, LP Shapiro, JM Bradner, WM Caudle; citation_volume=44; citation_publication_date=2014; citation_pages=279-87; citation_doi=10.1016/j.neuro.2014.07.008; citation_id=CR72 citation_journal_title=AIDS; citation_title=Impact of in-utero antiretroviral drug exposure on expression of membrane-associated transporters in mouse placenta and fetal brain; citation_author=JC Gilmore, G Zhang, DW Cameron, L Serghides, R Bendayan; citation_volume=35; citation_publication_date=2021; citation_pages=2249-58; citation_doi=10.1097/QAD.0000000000003009; citation_id=CR73 citation_journal_title=Pediatr Res; citation_title=Brain Bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice; citation_author=JF Watchko, MJ Daood, TWR Hansen; citation_volume=44; citation_publication_date=1998; citation_pages=763-6; citation_doi=10.1203/00006450-199811000-00020; citation_id=CR74 citation_journal_title=Pediatr Res; citation_title=High unbound bilirubin for age: a neurotoxin with major effects on the developing brain; citation_author=R Cayabyab, R Ramanathan; citation_volume=85; citation_publication_date=2019; citation_pages=183-90; citation_doi=10.1038/s41390-018-0224-4; citation_id=CR75 citation_journal_title=Lipids Health Dis; citation_title=Role of cholesterol and sphingolipids in brain development and neurological diseases; citation_author=G Hussain, J Wang, A Rasul, H Anwar, A Imran, M Qasim; citation_volume=18; citation_publication_date=2019; citation_pages=26; citation_doi=10.1186/s12944-019-0965-z; citation_id=CR76 citation_journal_title=Adv Nutr; citation_title=The importance of maternal folate status for brain development and function of offspring; citation_author=EFG Naninck, PC Stijger, EM Brouwer-Brolsma; citation_volume=10; citation_publication_date=2019; citation_pages=502-19; citation_doi=10.1093/advances/nmy120; citation_id=CR77