Effects and pharmacokinetics of isosorbide dinitrate in normal man

European Journal of Clinical Pharmacology - Tập 18 Số 3 - Trang 237-244 - 1980
S. Spörl-Radun1, G Betzien1, B. Kaufmann1, V. Liede1, U. Abshagen1
1Klinische Pharmakologie Boehringer Mannheim GmbH, Mannheim, Federal Republic of Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Assinder DF, Chasseaud LF, Taylor T (1977) Plasma isosorbide dinitrate concentrations in human subjects after administration of standard and sustained-release formulations. J Pharm Sci 66: 775?778

Bachmann K (1978) EKG-Telemetrie: Arrhythmien sicher erkannt. Selecta 46: 4306

Bergenwald L, Freyschuss U, Sjöstrand T (1977) The mechanism of orthostatic and haemorrhagic fainting. Scand J Clin Lab Invest 37: 209?216

Bogaert MG, Rosseel MT (1972) Vascular effects of the dinitrate and mononitrate esters of isosorbide, isomannide and isoidide. Naunyn-Schmiedeberg's Arch Pharmacol 275: 339?342

Bossi M, Cataldo G, Colombo A, Fiorista F, Gentili D, Pirelli S (1977) Ipotensione, bradicardia e prelipotimia da isosorbide dinitrato sublinguale nell' infarto miocardio in fase iniziale. G Ital Cardiol 7: 922?926

Bussmann WD, Löhner J, Kaltenbach M (1977) Orally administered isosorbide dinitrate in patients with and without left ventricular failure due to acute myocardial infarction. Am J Cardiol 39: 91?96

Chasseaud LF, Down WH, Grundy RK (1975) Concentrations of the vasodilator isosorbide dinitrate and its metabolites in the blood of human subjects. Eur J Clin Pharmacol 8: 157?160

Cheng TO (1971) Hypotension during coronary arteriography. Chest 60: 618

Chiche P, Baligadoo S, Barritault L (1976) Etude isotopique de l'éffet d'un dérivé nitré sur le volume sanguin pulmonaire. Application au traitement de l'oedème pulmonaire cardiogénique. Nouv Presse Méd 5: 1975?1978

Chin DA, Prue DG, Michelucci J, Kho BT, Warner CR (1977) Quantitative determination of isosorbide dinitrate and two metabolites in plasma. J Pharm Sci 66: 1143?1145

Come PC, Pitt B (1976) Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction. Circulation 54: 624?628

Epstein SE, Stampfer M, Beiser GD (1968) Role of the capacitance and resistance vessels in vagovasal syncope. Circulation 37: 524?533

Gray R, Chatterjee K, Vyden JK, Ganz W, Forrester JS, Swan HJC (1975) Hemodynamic and metabolic effects of isosorbide dinitrate in chronic congestive heart failure. Am Heart J 90: 346?352

Kovick RB, Tillisch JH, Berens SC, Bramowitz AD, Shine KI (1976) Vasodilator therapy for chronic left ventricular failure. Circulation 53: 322?328

Laufen H, Scharf F, Bartsch G (1978) Improved method for the rapid determination of isosorbide dinitrate in human plasma and its application in pharmacokinetic studies. J Chromatogr 146: 457?464

Lax A, Ceci V, Jacovella G (1977) Effeti stavorevoli dell'isosorbide dinitrato sublinguale ? Osservazioni su 9 casi personali. G Ital Cardiol 7, 816?817

Litchfield MH (1973) Recent news on the mechanism of nitrate ester metabolism. Drug Metab Rev 2, 239?264

Mansel-Jones D, Taylor T, Doyle E, Chasseaud LF, Darragh A, O'Kelly DA, Over H (1978) Plasma concentrations of isosorbide dinitrate after cutaneous and sublingual doses to human subjects. J Clin Pharmacol 18: 544?548

Mantle JA, Russell RO, Moraski RE, Rackley E (1976) Isosorbide dinitrate for the relief of severe heart failure after myocardial infarction. Am J Cardiol 37: 263?268

Michel D (1976) Beurteilung der Wirkung von Mononitraten mittels Ergometrie. In: Rudolpf W (ed) Nitrate ? Wirkung auf Herz und Kreislauf. Urban & Schwarzenberg, München, pp 24?25

Murrel W (1879) Nitroglycerine as a remedy for angina pectoris. Lancet 1: 80, 113, 151, 224

Needleman P (1976) Organic nitrate metabolism. Ann Rev Pharmacol Toxicol 16: 81?93

Needleman P, Johnson EM (1973) Mechanism of tolerance development to organic nitrates. J Pharmacol Exp Ther 184: 709?715

Randolph WF (1977) Single-entity coronary vasodilators. Fed Regist 42: 43127?43131

Russek HJ (1969) New dimensions in angina pectoris therapy. Geriatrics 24: 81?95

Schellong F, Lüderitz B (1954) Regulationsprüfung des Kreislaufs. Dr. Dietrich Steinkopf Verlag, Darmstadt

Shane SJ, Iazetta, JJ, Crisholm AW, Berka JF, Leung DL (1978) Plasma concentrations of isosorbide dinitrate and its metabolites after chronic high oral dosage in man. Br J Clin Pharmacol 6: 37?41

Sherber DA, Gelb IJ (1960) Treatment of coronary insufficiency with isosorbide dinitrate. Circulation 22: 809

Sjöstrand T (1973) Circulatory control via vagal afferents VI. The bleeding bradycardia in the rat, its elicitation and relation to the release of vasopressin. Acta Physiol Scand 89: 39?50

Smolen VF, Weigand WA (1973) Drug bioavailability and pharmacokinetic analysis from pharmacological data. J Pharmacokinet Biopharm 1: 329?336

Smolen VF, Williams EJ (1977) Recommended guidelines and methodology for the evaluation of the pharmacological effectiveness and comparative bioavailability of organic nitrate, antianginal, drug products. In: Drug bioavailability as related to physiological response, vol. 1. Bur of Drugs FDA

Smolen VF (1978) Bioavailability and pharmacokinetic analysis of drug responding systems. Ann Rev Pharmacol Toxicol 18: 495?522

Stauch M, Grewe N, Nissen H (1975) Die Wirkung von 2-und 5-Isosorbidmononitrat auf das Belastungs-EKG von Patienten mit Koronarinsuffizienz. Verh Dtsch Ges Kreislaufforschg 41: 182?184

Stauch M, Grewe N, Nissen H (1978) Hämodynamik nach Isosorbiddinitrat, 2- und 5-Isosorbidmononitrat bei Patienten mit Angina pectoris unter Vorhofstimulation. Herz 3: 223

Wendt RL (1972) Systemic and coronary vascular effects of the 2- and 5-mononitrate esters of isosorbide. J Pharmacol Exp Ther 180: 732?742

Winsor T, Kaye H, Milis B (1972) Hemodynamic response of oral long-acting nitrates: Evidence of gastrointestinal absorption. Chest 62: 407?413