Effect of topical ciprofloxacin/dexamethasone or dexamethasone alone on acute Streptococcus pneumoniae rhinosinusitis in mice

Otolaryngology - Head and Neck Surgery - Tập 138 - Trang 340-346 - 2008
Asli Sahin-Yilmaz1, Fuad Baroody1, Adam Markaryan, Kenneth Thompson2, G. Michael Wall3, Robert Naclerio1
1Department of Surgery, Section of Otolaryngology–Head and Neck Surgery, The University of Chicago, Chicago, IL
2Department of Pathology, The University of Chicago, Chicago, IL
3Alcon Research, Ltd, Fort Worth, TX.

Tóm tắt

OBJECTIVETo test whether intranasal ciprofloxacin/dexamethasone or dexamethasone alone affects the course of acute bacterial rhinosinusitis in mice.STUDY DESIGNWe performed a randomized, double‐blind, parallel, placebo‐controlled study in mice.SUBJECTS AND METHODSThree groups of 10 C57B1/6 mice were infected with Streptococcus pneumoniae, and then 1 day later randomized to treatment with placebo, ciprofloxacin plus dexamethasone, or dexamethasone. The mice were killed 3 or 10 days after treatment was begun.RESULTSThe placebo‐treated mice became infected and developed an inflammatory cell infiltration in their sinuses. None of the treatments significantly affected the course of the illness.CONCLUSIONThe lack of topical, intranasal efficacy of ciprofloxacin and dexamethasone could be attributed to subpotent dosage, rapid nasal clearance, or inability of the drops to reach the site of infection. Treatment with dexamethasone neither improved nor worsened the bacterial infection.

Tài liệu tham khảo

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Thông tin xuất bản

Otolaryngology - Head and Neck Surgery

Tập 138

340-346

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