Effect of long-term injection of high doses of potassium iodide on iodine metabolism in rat thyroid gland
Tóm tắt
Concentration of thyroid hormones in the serum of the rats after 14-day injections of potassium iodide (1, 3, 10, 100, and 500 physiological daily doses) did not differ from the control values. Excessive administration of potassium iodide increased the total iodide content in the rat thyroid tissue by 60–121% (35–108% and 94–128% for the protein-bound and free iodide, respectively), indicating the activation of the uptake and organification of iodide. The long-term injection of both low and high doses of potassium iodide increased the activity of catalase by 8–18% and SOD by 33–50% and enhanced the level of toxic LPO products reacting with thiobarbituric acid by 15–38%. It is suggested that reactive oxygen species and the excessive iodination of proteins (particularly thyroglobulin) induced by the long-term administration of high doses of potassium iodide can play an important role in the development of thyroid dysfunctions and autoimmune diseases.
Tài liệu tham khảo
citation_journal_title=Zdravookhranenie Belarusi; citation_author=I.M. Khmara, T.V. Matveichik, L.N. Astakhova, E.V. Shemyakina, M.V. Chaikovskii; citation_volume=2; citation_publication_date=1996; citation_pages=15-18; citation_id=CR1
citation_journal_title=Thyroid; citation_author=C. Ruwhof, H.A. Drexhage; citation_volume=11; citation_publication_date=2001; citation_pages=427-436; citation_doi=10.1089/105072501300176381; citation_id=CR2
citation_journal_title=J. Biol. Chem.; citation_author=B. J. Wolff, I. L. Chaikoff; citation_volume=174; citation_publication_date=1948; citation_pages=555-560; citation_id=CR3
citation_journal_title=Metabolism; citation_author=T. Paul, B. Meyers, R.J. Witorsch, S. Pino, S. Chipkin, S.H. Ingbar, L.E. Braverman; citation_volume=37; citation_publication_date=1988; citation_pages=121-124; citation_doi=10.1016/S0026-0495(98)90004-X; citation_id=CR4
citation_journal_title=Endocrinology; citation_author=M. Vitale, T. Matola, F. D’Ascoli, S. Salzano, E. Bogazzi, G. Fenzi, E. Martino, G. Rossi; citation_volume=141; citation_publication_date=2000; citation_pages=598-605; citation_doi=10.1210/en.141.2.598; citation_id=CR5
citation_journal_title=Mol. Cell. Endocrinol.; citation_author=J.F. Denef, M.C. Many, M.F. Hove; citation_volume=121; citation_publication_date=1996; citation_pages=101-103; citation_doi=10.1016/0303-7207(96)03848-8; citation_id=CR6
citation_journal_title=J. Endocrinol. Invest.; citation_author=J. Habermann, B. Leisner, A. Witte, C.R. Pickardt, P.C. Scriba; citation_volume=5; citation_publication_date=1982; citation_pages=153-156; citation_id=CR7
citation_journal_title=Mol. Cell. Endocrinol.; citation_author=N. Uyttersprot, N. Pelgrims, N. Carrasco, C. Gervy, C. Maenhaut, J.E. Dumont, F. Miot; citation_volume=131; citation_publication_date=1997; citation_pages=195-203; citation_doi=10.1016/S0303-7207(97)00108-1; citation_id=CR8
citation_journal_title=J. Clin. Endocrinol. Metab.; citation_author=L.C. Cardoso, D.C. Martins, M.D. Figueiredo, D. Rosenthal, M. Vaisman, A.K. Violante, D.P. Carvalho; citation_volume=86; citation_publication_date=2001; citation_pages=4339-4343; citation_doi=10.1210/jc.86.9.4339; citation_id=CR9
citation_journal_title=Mol. Cell. Endocrinol.; citation_author=R. Ohayon, J.M. Boeynaems, J.C. Braekman, H. Bergen, Y. Gorin, A. Virion; citation_volume=99; citation_publication_date=1994; citation_pages=133-141; citation_doi=10.1016/0303-7207(94)90156-2; citation_id=CR10
citation_journal_title=Endocrinology; citation_author=P.H. Eng, G.R. Cardona, S.L. Fang, M. Previti, S. Alex, N. Carrasco, W.W. Chin, L.E. Braverman; citation_volume=140; citation_publication_date=1999; citation_pages=3404-3410; citation_doi=10.1210/en.140.8.3404; citation_id=CR11
citation_journal_title=Endocrinology; citation_author=R. Ekholm, U. Bjorkman; citation_volume=138; citation_publication_date=1997; citation_pages=2871-2878; citation_doi=10.1210/en.138.7.2871; citation_id=CR12
citation_journal_title=J. Biol. Chem.; citation_author=R. Kuliawat, P. Arvan; citation_volume=269; citation_publication_date=1994; citation_pages=4922-4927; citation_id=CR13
Yamamoto, K. and DeGroot, L.J., Endocrinology, vol. 96, pp. 1022–1029.
citation_journal_title=Exp. Mol. Pathol; citation_author=I. Mahmoud, I. Colin, M.C. Many, J.F. Denef; citation_volume=44; citation_publication_date=1986; citation_pages=259-271; citation_doi=10.1016/0014-4800(86)90040-7; citation_id=CR15
citation_journal_title=Thyroid; citation_author=J.T. Dunn, H.E. Crutchfield, R. Gutekunst, D. Dunn; citation_volume=3; citation_publication_date=1993; citation_pages=119-123; citation_doi=10.1089/thy.1993.3.119; citation_id=CR16
citation_journal_title=Analyt. Biochem.; citation_author=N.M. Alexander; citation_volume=4; citation_publication_date=1962; citation_pages=341-345; citation_doi=10.1016/0003-2697(62)90097-0; citation_id=CR17
citation_inbook_title=Metody sovremennoi biokhimii; citation_publication_date=1977; citation_pages=66-68; citation_id=CR18; citation_author=I.D. Stal’naya; citation_author=T.G. Garishvili; citation_publisher=Meditsina
Korolyuk, M.A., Ivanova, L.I., Maiorova, I.G., and Tokareva, V.E., Lab. Delo, 1988, no. 1, pp. 16–19.
citation_journal_title=Vopr. Med. Khim.; citation_author=V.A. Kostyuk, A.I. Potapovich, Zh.V. Kovaleva; citation_volume=36; citation_issue=2; citation_publication_date=1990; citation_pages=88-91; citation_id=CR20
citation_journal_title=J. Nutr.; citation_author=M.B. Zimmermann; citation_volume=134; citation_publication_date=2004; citation_pages=1673-1677; citation_id=CR21
citation_journal_title=Autoimmun. Rev.; citation_author=N.R. Rose, R. Bonita, C.L. Burek; citation_volume=1; citation_publication_date=2002; citation_pages=97-103; citation_doi=10.1016/S1568-9972(01)00016-7; citation_id=CR22
citation_journal_title=Acta Biochim. Pol.; citation_author=S. Lupachyk, Z. Niatsetskaya, L. Nadolnik; citation_volume=50; citation_issue=Suppl.1; citation_publication_date=2003; citation_pages=50-51; citation_id=CR23
citation_journal_title=J. Endocrinol. Invest.; citation_author=E.M. Allen; citation_volume=15; citation_publication_date=1992; citation_pages=519-523; citation_id=CR24
citation_journal_title=Clin. Cancer Res.; citation_author=H.C. Ha, A. Thiagalingam, B.D. Nelkin, R.A. Casern; citation_volume=63; citation_publication_date=2000; citation_pages=3783-3787; citation_id=CR25