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Tác động của buspirone đến mức prolactin trong máu và sự chuyển hóa dopamine ở vùng đuôi của chuột cống
Tóm tắt
Buspirone, một hợp chất an thần hiệu quả, đã tạo ra sự gia tăng mức prolactin (PRL) trong máu của chuột cống theo liều lượng, kéo dài và tương đối lâu. Sự kích thích tiết PRL bởi buspirone có tính cộng hưởng với tác động của α-methyl-p-tyrosine (AMPT) hoặc γ-butyrolactone. Trong điều kiện in vitro, buspirone không có tác động đến sự tiết PRL từ tuyến yên của chuột cống nhưng đã chặn tác động ức chế của dopamine (DA). Buspirone cũng làm tăng sự chuyển hóa DA trong vùng đuôi qua việc đo lường sự suy giảm mức DA vùng đuôi do AMPT gây ra. Những kết quả này chứng minh khả năng của buspirone trong việc chặn các thụ thể DA ở tuyến yên và vùng đuôi.
Từ khóa
#Buspirone #prolactin #dopamine #tuyến yên #chuột cống #chuyển hóa dopamineTài liệu tham khảo
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