Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

JAMA - Journal of the American Medical Association - Tập 324 Số 13 - Trang 1317 - 2020
Derek C. Angus1,2, Scott Berry3,4, Farah Al-Beidh5, Djillali Annane6,7,8, Judith Marín‐Corral9, Abi Beane10, Wilma van Bentum-Puijk4, Lindsay R. Berry11, Zahra Bhimani12, Marc J. M. Bonten13,4, Charlotte Summers14,15, Meredith Buxton16, Shailesh Bihari17, Allen C. Cheng18,19, Menno D. de Jong20, Michelle A. Detry11, Lise J Estcourt21,22, Mark Fitzgerald11, Zhuxuan Fu23, Cameron Green18, Rashan Haniffa24,25, Christopher M. Horvat1,2, Sebastiaan Hullegie4, Peter Krüger26, François Lamontagne27, Patrick R. Lawler28, Grégoire Le Gal29, Elizabeth Lorenzi11, J. Kenneth Baillie30,12, Daniel F. McAuley31, Anna McGlothlin11, Shay McGuinness18,32,33,34, Bryan J. McVerry35, Stephanie A. Montgomery1,2, Paul Mouncey36, Srinivas Murthy37, Alistair Nichol18,38,39,40, Rachael Parke32,33,41,34, Kathy Rowan36, Anil Hormis11, Simone Piva12, Christina Saunders11, Christopher Seymour1,2, Anne M. Turner33, Frank L. van de Veerdonk42, Balasubramanian Venkatesh43,44, Ryan Zarychanski45, Roger Lewis11,46,47, Colin McArthur48,33, Steven A. Webb18,29,49, Anthony Gordon5
1The Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
2The UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania
3Intensive Care Center, University Medical Center Utrecht, Utrecht, The Netherlands
4Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
5Division of Anaesthetics, Pain Medicine and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom
6Intensive Care Unit, Raymond Poincaré Hospital (AP-HP), Paris, France
7Simone Veil School of Medicine, University of Versailles, Versailles, France
8University Paris Saclay, Garches, France
9Intensive Care Department, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia
10Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
11Berry Consultants LLC, Austin, Texas
12Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada
13Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
14Bristol Royal Informatory, Bristol, United Kingdom
15University of Bristol, Bristol, United Kingdom
16Global Coalition for Adaptive Research, San Francisco, California
17Helix, Monash University, Melbourne, Victoria, Australia
18Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
19Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Victoria, Australia
20Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, the Netherlands
21NHS Blood and Transplant, Bristol, United Kingdom
22Transfusion Medicine, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
23Department of Microbiology, Antwerp University Hospital, Antwerp, Belgium
24Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand
25Network for Improving Critical care Systems and Training, Colombo, Sri Lanka
26Intensive Care Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia
27Université de Sherbrooke, Sherbrooke, Quebec, Canada
28Cardiac Intensive Care Unit, Peter Munk Cardiac Centre, University Health Network, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
29School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
30Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
31Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom
32Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand
33Medical Research Institute of New Zealand, Wellington, New Zealand
34The Health Research Council of New Zealand, Wellington, New Zealand
35Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
36Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, United Kingdom
37University of British Columbia School of Medicine, Vancouver, Canada
38Department of Anesthesia and Intensive Care, St Vincent's University Hospital, Dublin, Ireland
39Department of Intensive Care, Alfred Health, Melbourne, Victoria, Australia
40School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
41School of Nursing, University of Auckland, Auckland, New Zealand
42Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
43Southside Clinical Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia
44The George Institute for Global Health, Sydney, Australia
45Department of Medicine, Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada
46Department of Emergency Medicine, David Geffen School of Medicine at University of California, Los Angeles
47Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California
48Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand
49St John of God Hospital, Subiaco, Western Australia, Australia

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JAMA - Journal of the American Medical Association

Tập 324 Số 13

1317

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