Efectos vasculares y moleculares de los andrógenos endógenos en un modelo experimental en conejos ateroscleróticos

Clínica e Investigación en Arteriosclerosis - Tập 19 - Trang 278-286 - 2007
Darío Echeverri1, Mónica Díaz2, Alexandra Delgadillo1, Félix Montes1, Fernando Lizcano2
1Laboratorio de Investigación en Función Vascular. Fundación Cardioinfantil-Instituto de Cardiología. Bogotá. Colombia
2Centro de Investigaciones Biomédicas. Universidad de La Sabana. Chía. Colombia

Tài liệu tham khảo

Rosamond, 2007, for the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2007 Update. A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Circulation, 115, 1, 10.1161/CIRCULATIONAHA.106.179918 Hulley, 1998, Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women; Heart and Estrogen/progestin Replacement Study (HERS) Research Group, JAMA, 280, 605, 10.1001/jama.280.7.605 2002, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial, JAMA, 288, 321, 10.1001/jama.288.3.321 Kalin, 1990, Sex hormones and coronary disease: a review of the clinical studies, Steroids, 55, 30, 10.1016/0039-128X(90)90058-J Yarnell, 1993, Endogenous sex hormones and ischemic heart disease in men. The Caerphilly prospective study, Arterioscler Thromb, 13, 517, 10.1161/01.ATV.13.4.517 Barrett-Connor, 1995, Prospective study of endogenous sex hormones and fatal cardiovascular disease in postmenopausal women, BMJ, 311, 1193, 10.1136/bmj.311.7014.1193 Barrett-Connor, 1995, The epidemiology of DHEAS and cardiovascular disease, Ann N Y Acad Sci, 774, 259, 10.1111/j.1749-6632.1995.tb17386.x-i1 Yarnell, 1993, Endogenous sex hormones and ischemic heart disease in men. The Caerphilly Prospective Study, Arterioscler Thromb, 13, 517, 10.1161/01.ATV.13.4.517 Marques-Vidal, 1995, Relationships of plasminogen activator inhibitor activity and lipoprotein (a) with insulin, testosterone, 17b-estradiol, and testosterone binding globulin in myocardial infarction patients and healthy controls, J Clin Endocrinol Metab, 80, 1794, 10.1210/jc.80.6.1794 Larsen, 1993, Effect of testosterone on atherogenesis in cholesterol-fed rabbits with similar plasma cholesterol levels, Atherosclerosis, 99, 79, 10.1016/0021-9150(93)90053-W Eich, 1993, Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation, Circulation, 8, 261, 10.1161/01.CIR.87.1.261 Bruck, 1997, Gender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbits, Arterioscler Thromb Vasc Biol, 17, 2192, 10.1161/01.ATV.17.10.2192 Adams, 1995, Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness, Arterioscler Thromb Vasc Biol, 15, 562, 10.1161/01.ATV.15.5.562 Alexandersen, 1999, Natural androgens inhibit male atherosclerosis. A study in castrated, cholesterol-fed rabbits, Circ Res, 84, 813, 10.1161/01.RES.84.7.813 Alexandersen, 1996, The relationship of natural androgens to coronary heart disease in males: a review, Atherosclerosis, 125, 1, 10.1016/0021-9150(96)05864-9 Abela, 1995, Triggering of Plaque Disruption and Arterial Thrombosis in an Atherosclerotic Rabbit Model, Circulation, 91, 776, 10.1161/01.CIR.91.3.776 Huraux, 1998, A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery, Anesthesiology, 88, 1654, 10.1097/00000542-199806000-00030 Gordon, 1988, Reduction of atherosclerosis by administration of dehydroepiandrosterone: a study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury, J Clin Invest, 82, 712, 10.1172/JCI113652 Uyanik, 1997, Beneficial effects of testosterone on the lipoprotein profile in healthy elderly men: a placebo controlled study, Jpn Heart J, 38, 73, 10.1536/ihj.38.73 Yarnell, 1993, Endogenous sex hormones and ischemic heart disease in men. The Caerphilly Prospective Study, Arterioscler Thromb, 13, 517, 10.1161/01.ATV.13.4.517 Phillips, 1994, The association of hypotestosteronemia with coronary artery disease in men, Arterioscler Thromb, 14, 701, 10.1161/01.ATV.14.5.701 Mitchell, 1994, Evidence for an association between dehydroepiandrosterone sulfate and non-fatal, premature myocardial infarction in males, Circulation, 89, 89, 10.1161/01.CIR.89.1.89 Herrington, 1995, Dehydroepiandrosterone and coronary atherosclerosis, Ann N Y Acad Sci, 774, 271, 10.1111/j.1749-6632.1995.tb17387.x-i1 Grady, 1992, Hormone therapy to prevent disease and prolong life in postmenopausal women, Ann Intern Med, 117, 1016, 10.7326/0003-4819-117-12-1016 Van den Beld, 2003, Endogenous hormones and carotid atherosclerosis in elderly men, Am J Epidemiol, 157, 25, 10.1093/aje/kwf160 Hak, 2002, Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study, J Clin Endocrinol Metab, 87, 3632, 10.1210/jc.87.8.3632 Alexandersen, 1996, The relationship of natural androgens to coronary heart disease in males: a review, Atherosclerosis, 125, 1, 10.1016/0021-9150(96)05864-9 Simpson, 1997, Aromatase expression in health and disease, Recent Prog Horm Res, 52, 185 Malkin, 2003, Testosterone as a protective factor against atherosclerosis—immunomodulation and influence upon plaque development and stability, J Endocrinol, 178, 373, 10.1677/joe.0.1780373 Deenadayalu, 2001, Testosterone relaxes coronary arteries by opening the large-conductance, calciumactivated potassium channel, Am J Physiol Heart Circ Physiol, 281, H1720, 10.1152/ajpheart.2001.281.4.H1720 Tep-areenan, 2002, Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels, Br J Pharmacol, 135, 735, 10.1038/sj.bjp.0704522 Yildiz, 2005, Testosterone relaxes human internal mammary artery In-Vitro, J Cardiovasc Pharmacol, 45, 580, 10.1097/01.fjc.0000161400.06704.1e Devlin, 2002, Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size, Proc Nat A Sci USA, 99, 6280, 10.1073/pnas.092324399 Tontonoz, 2003, Liver X receptor signaling pathways in cardiovascular disease, Mol Endocrinol, 17, 985, 10.1210/me.2003-0061 Joseph, 2003, LXRs: new therapeutic targets in atherosclerosis?, Current Opinion Pharmacol, 3, 192, 10.1016/S1471-4892(03)00009-2 Soumian, 2005, ABCA1 and atherosclerosis, Vasc Med, 10, 109, 10.1191/1358863x05vm593ra Liu, 2005, Androgens and cardiovascular disease, Endocrine Reviews, 24, 313, 10.1210/er.2003-0005 Heinlein, 2002, The roles of androgen receptors and androgen- binding proteins in nongenomic androgen actions, Mol Endocrinol, 16, 2181, 10.1210/me.2002-0070 Eicheler, 1995, Immunohistochemical evidence for differential distribution of 5a reductase isoenzymes in human skin, Br J Dermatol, 133, 371, 10.1111/j.1365-2133.1995.tb02663.x Harada, 1999, Localized expression of aromatase in human vascular tissues, Circ Res, 84, 1285, 10.1161/01.RES.84.11.1285 Friedl, 2000, Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages, Life Sci, 68, 417, 10.1016/S0024-3205(00)00953-X