Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene

Vaccine - Tập 16 Số 13 - Trang 1336-1343 - 1998
Hugh S. Mason1, Tariq A. Haq2, John D. Clements3, Charles J. Arntzen4
1Boyce Thompson Institute for Plant Research, Ithaca, NY 14853-1801, USA
2Texas A and M Institute of Biosciences and Technology, 2121 W. Holcombe Boulevard, Houston, TX 77030, USA
3Department of Microbiology and Immunology SL 38, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112-2699, USA
4Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853‐1801, USA;

Tóm tắt

Từ khóa


Tài liệu tham khảo

Sixma, 1991, Crystal structure of cholera toxin-related heat-labile enterotoxin from E. coli, Nature, 351, 371, 10.1038/351371a0

Clemens, 1990, Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up, Lancet, 335, 270, 10.1016/0140-6736(90)90080-O

Clemens, 1991, Field trial of oral cholera vaccines in Bangladesh: serum vibriocidal and antitoxic antibodies as markers of the risk of cholera, J. Infect. Dis., 163, 1235, 10.1093/infdis/163.6.1235

Lebens, 1993, Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines, Bio/Technology, 11, 1574

Schonberger, 1991, Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiae, Mol. Microbiol., 5, 2663, 10.1111/j.1365-2958.1991.tb01975.x

Arntzen, 1997, Oral vaccine production in the edible tissues of transgenic plants, 263

Haq, 1995, Oral immunization with a recombinant bacterial antigen produced in transgenic plants, Science, 268, 714, 10.1126/science.7732379

Clements, 1984, Construction of a potential live oral bivalnet vaccine for typhoid and cholera-Escherichia coli-related diarrheas, Infect. Immun., 46, 564, 10.1128/iai.46.2.564-569.1984

Wada, 1990, Codon usage tabulated from the GenBank genetic sequence data, Nucleic Acids Res., 18, 2367, 10.1093/nar/18.suppl.2367

Perlak, 1991, Modification of the coding sequence enhances plant expression of insect control proteins, 88, 3324

Adang, 1993, The reconstruction and expression of a Bacillus thruingiensis cryIIIA gene in protoplasts and potato plants, Plant Mol. Biol., 21, 1131, 10.1007/BF00023609

Newman, 1993, DST sequences, highly conserved among plant SAUR genes, target reporter transcripts for rapid decay in tobacco, Plant Cell, 5, 701

Wenzler, 1989, A rapid and efficient transformation method for the production of large numbers of trangenic potato plants, Plant Sci., 63, 79, 10.1016/0168-9452(89)90103-9

Mason, 1992, Expression of hepatitis B surface antigen in transgenic plants, 89, 11745

Dickinson, 1995, Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity, Infect. Immun., 63, 1617, 10.1128/iai.63.5.1617-1623.1995

Guidry, 1997, Role of receptor binding in toxicity, immunogenicity and adjuvanticity of Escherichia coli heat-labile enterotoxin, Infect. Immun., 65, 4943, 10.1128/iai.65.12.4943-4950.1997

Richardson, 1984, Sealed adult mice: a new model for enterotoxin evaluation, Infect. Immun., 43, 482, 10.1128/iai.43.2.482-486.1984

Hirst, 1995, Biogenesis of cholera toxin and related oligomeric enterotoxins, 123

Hein, 1996, Expression of cholera toxin subunits in plants, Ann. N.Y. Acad. Sci., 792, 50, 10.1111/j.1749-6632.1996.tb32490.x

Arakawa, 1998, Efficacy of a food plant-based oral cholera toxin B subunit vaccine, Nature Biotech., 16, 292, 10.1038/nbt0398-292