Drug-induced changes in responding are dependent on baseline stimulus-reinforcer contingencies
Tóm tắt
The disruptive effect of four drugs was examined using a multiple-schedule procedure that allowed the assessment of behavioral resistance to change. With rats as subjects, responding in one component was maintained on a variable-interval (VI) 30-sec schedule, and responding in the other components was maintained using a VI 30-sec schedule that operated concurrently with a variable-time 30-sec schedule. Quinpirole and fluoxetine, but not d-amphetamine, resulted in greater changes relative to baseline for responding in the component associated with the weaker stimulus-reinforcer contingency (VI 30-sec component). This effect is consistent with the view that the degree to which dopamine-altering drugs change responding is dependent on the strength of the baseline stimulus-reinforcer contingencies as opposed to the baseline response-reinforcer contingencies. In contrast, the assessment of d-amphetamine in terms of resistance to change was confounded by a simultaneous weakening of stimulus control that interfered with the stimulus-reinforcer contingencies established across the levers.
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