Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia

Asahi, 2001, Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood brain barrier and white matter components after cerebral ischemia, J. Neurosci., 21, 7724, 10.1523/JNEUROSCI.21-19-07724.2001 Barza, 1975, Relationship between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs, Antimicrob. Agents Chemother., 8, 713, 10.1128/AAC.8.6.713 Boyle, 1998, Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease, J. Vasc. Surg., 27, 354, 10.1016/S0741-5214(98)70367-2 Brown, 2004, Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial, Arterioscler. Thromb. Vasc. Biol., 24, 733, 10.1161/01.ATV.0000121571.78696.dc Burggraf, 2007, Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia, Neurobiol. Dis., 25, 506, 10.1016/j.nbd.2006.10.013 Chen, 1997, Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin, Cell, 91, 917, 10.1016/S0092-8674(00)80483-3 Chen, 1998, Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia, J. Neurosci., 18, 4914, 10.1523/JNEUROSCI.18-13-04914.1998 Cho, 2006, Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia, Neurosci. Lett., 404, 330, 10.1016/j.neulet.2006.06.010 Choi, 1996, Ischemia-induced neuronal apoptosis, Curr. Opin. Neurobiol., 6, 667, 10.1016/S0959-4388(96)80101-2 Clark, 1994, Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment, Stroke, 25, 1411, 10.1161/01.STR.25.7.1411 Clark, 1997, Doxycycline treatment reduces ischemic brain damage in transient middle cerebral artery occlusion in the rat, J. Mol. Neurosci., 9, 103, 10.1007/BF02736854 Endoh, 1994, Expression of the neural form of nitric oxide synthase by CA1 hippocampal neurons and other central nervous system neurons, Neuroscience, 63, 679, 10.1016/0306-4522(94)90514-2 Gabler, 1991, Suppression of human neutrophil functions by tetracyclines, J. Periodontal Res., 26, 52, 10.1111/j.1600-0765.1991.tb01626.x Gidday, 2005, Leukocyte-derived matrix metalloproteinase-9 mediates blood–brain barrier breakdown and it proinflammatory after transient focal cerebral ischemia, Am. J. Physiol. Heart Circ. Physiol., 289, H558, 10.1152/ajpheart.01275.2004 Golub, 1998, Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms, Adv. Dent. Res., 12, 12, 10.1177/08959374980120010501 Gu, 2002, S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death, Science, 297, 1186, 10.1126/science.1073634 Jantzie, 2005, Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia–ischemia, J. Cereb. Blood Flow Metab., 25, 314, 10.1038/sj.jcbfm.9600025 Kim, 2005, Doxycycline inhibits TGF-β1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells, Invest. Ophthalmol. Vis. Sci., 46, 840, 10.1167/iovs.04-0929 Kirino, 1982, Delayed neuronal death in the gerbil hippocampus following ischemia, Brain Res., 239, 57, 10.1016/0006-8993(82)90833-2 Lee, 2008, PPARγ agonist pioglitazone rescues neuronal cell damage after transient global cerebral ischemia through matrix metalloproteinase inhibition, Eur. J. Neurosci., 27, 334, 10.1111/j.1460-9568.2007.06007.x Lee, 2004, Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia, J. Neurosci., 24, 671, 10.1523/JNEUROSCI.4243-03.2004 Lee, 2004, Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model, Stroke, 35, 1715, 10.1161/01.STR.0000129334.05181.b6 Lo, 2002, Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases, J. Neurosci. Res., 69, 1, 10.1002/jnr.10270 MacManus, 1993, Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain, Neurosci. Lett., 164, 89, 10.1016/0304-3940(93)90864-H Mun-Bryce, 2002, Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation, Brain Res., 933, 42, 10.1016/S0006-8993(02)02303-X Nitatori, 1995, Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis, J. Neurosci., 15, 1001, 10.1523/JNEUROSCI.15-02-01001.1995 Paxinos, 2001 Pulsinelli, 1982, Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol., 11, 491, 10.1002/ana.410110509 Rosenberg, 1995, Matrix metalloproteinases in brain injury, J. Neurotrauma, 12, 833, 10.1089/neu.1995.12.833 Xu, 2004, Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion–reperfusion in rats, BMC Neurol., 4, 7, 10.1186/1471-2377-4-7 Yong, 2007, Targeting MMPs in acute and chronic neurological conditions, Neurotherapeutics, 4, 580, 10.1016/j.nurt.2007.07.005 Yrj ä nheikki, 1999, A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window, Proc. Natl. Acad. Sci. U. S. A., 96, 13496, 10.1073/pnas.96.23.13496 Zalewska, 2003, Transient forebrain ischemia modulates signal transduction from extracellular matrix in gerbil hippocampus, Brain Res., 977, 62, 10.1016/S0006-8993(03)02742-2 Zhao, 2007, Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke, Stroke, 38, 748, 10.1161/01.STR.0000253500.32979.d1