Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance

Molecular Immunology - Tập 56 - Trang 104-112 - 2013
Dan Liu1, Ming Shi2, Chenyang Duan3, Hongyu Chen2, Yabin Hu2, Zhengyan Yang2, Huijun Duan1, Ning Guo2
1Department of Pathology, Hebei Medical University, Shijiazhuang 050017, PR China
2Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing 100850, PR China
3Company Five of Cadet Brigade, Third Military Medical University, Chongqing 400038, PR China

Tài liệu tham khảo

Arteaga, 2012, Treatment of HER2-positive breast cancer: current status and future perspectives, Nature Reviews Clinical Oncology, 9, 16, 10.1038/nrclinonc.2011.177 Baselga, 2009, Novel anticancer targets: revisiting ERBB2 and discovering ERBB3, Nature Reviews Cancer, 9, 463, 10.1038/nrc2656 Bilder, 2000, Collective nomenclature for LAP proteins, Nature Cell Biology, 2, E114, 10.1038/35017119 Borg, 2000, ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor, Nature Cell Biology, 2, 407, 10.1038/35017038 Bossinger, 2004, The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413, Developmental Biology, 268, 448, 10.1016/j.ydbio.2004.01.003 Dai, 2006, Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex, Journal of Biological Chemistry, 281, 927, 10.1074/jbc.M507360200 Dan, 2010, Erbin, a negative regulator in diverse signal pathways, Current Protein and Peptide Science, 11, 759, 10.2174/138920310794557673 Dillon, 2002, Basolateral targeting of ERBB2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C-terminal ERBIN-binding domain, Molecular and Cellular Biology, 22, 6553, 10.1128/MCB.22.18.6553-6563.2002 Ellenbroek, 2012, Cell polarity proteins and cancer, Seminars in Cancer Biology, 22, 208, 10.1016/j.semcancer.2012.02.012 Elsum, 2012, The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man, Essays in Biochemistry, 53, 141, 10.1042/bse0530141 Engelman, 2009, Targeting PI3K signalling in cancer: opportunities, challenges and limitations, Nature Reviews Cancer, 9, 550, 10.1038/nrc2664 Garrett, 2003, The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors, Molecular Cell, 11, 495, 10.1016/S1097-2765(03)00048-0 Huang, 2001, Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95, Journal of Biological Chemistry, 276, 19318, 10.1074/jbc.M100494200 Huang, 2003, Erbin suppresses the MAP kinase pathway, Journal of Biological Chemistry, 278, 1108, 10.1074/jbc.M205413200 Hynes, 2005, ERBB receptors and cancer: the complexity of targeted inhibitors, Nature Reviews Cancer, 5, 341, 10.1038/nrc1609 Hynes, 2009, ErbB receptors and signaling pathways in cancer, Current Opinion in Cell Biology, 21, 177, 10.1016/j.ceb.2008.12.010 Izawa, 2002, ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells, Genes to Cells, 7, 475, 10.1046/j.1365-2443.2002.00533.x Jaulin-Bastard, 2002, Interaction between Erbin and a Catenin-related protein in epithelial cells, Journal of Biological Chemistry, 277, 2869, 10.1074/jbc.M109652200 Jaulin-Bastard, 2001, The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins, Journal of Biological Chemistry, 276, 15256, 10.1074/jbc.M010032200 Junttila, 2009, Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941, Cancer Cell, 15, 429, 10.1016/j.ccr.2009.03.020 Kolch, 2003 Legouis, 2000, LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans, Nature Cell Biology, 2, 415, 10.1038/35017046 Liu, 2012, c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin, PLoS ONE, 7, e42903, 10.1371/journal.pone.0042903 Martin-Belmonte, 2012, Epithelial cell polarity, stem cells and cancer, Nature Reviews Cancer, 12, 23, 10.1038/nrc3169 Nagata, 2004, PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients, Cancer Cell, 6, 117, 10.1016/j.ccr.2004.06.022 Nakagawa, 2004, Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix, British Journal of Cancer, 90, 194, 10.1038/sj.bjc.6601465 Rangwala, 2005, Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells, Journal of Biological Chemistry, 280, 11790, 10.1074/jbc.M414154200 Shi, 2011, The beta2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells, Breast Cancer Research and Treatment, 125, 351, 10.1007/s10549-010-0822-2 Shi, 2012, beta2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes, International Journal of Cardiology Spector, 2009, Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer, Journal of Clinical Oncology, 27, 5838, 10.1200/JCO.2009.22.1507 Stern, 2012, Improving treatment of HER2-positive cancers: opportunities and challenges, Science Translational Medicine, 4, 127rv122, 10.1126/scitranslmed.3001539 Thompson, 2004, Putting the rap on Akt, Journal of Clinical Oncology, 22, 4217, 10.1200/JCO.2004.01.103 Vivanco, 2002, The phosphatidylinositol 3-Kinase AKT pathway in human cancer, Nature Reviews Cancer, 2, 489, 10.1038/nrc839 Warner, 2003, Identification of three novel Smad binding proteins involved in cell polarity, FEBS Letters, 539, 167, 10.1016/S0014-5793(03)00155-8 Wu, 2010, Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion, Nature, 463, 545, 10.1038/nature08702 Yuan, 2008, HER2-dependent MMP-7 expression is mediated by activated STAT3, Cellular Signalling, 20, 1284, 10.1016/j.cellsig.2008.02.017 Zhan, 2008, Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma, Cell, 135, 865, 10.1016/j.cell.2008.09.045 Zhang, 2008, Overexpression, refolding, purification of Erbin PDZ domain from Escherichia coli and preparation of its polyclonal antibody, Preparative Biochemistry and Biotechnology, 38, 282, 10.1080/10826060802165105