Does methylphenidate improve academic performance? A systematic review and meta-analysis

European Child & Adolescent Psychiatry - Tập 28 - Trang 155-164 - 2018
Anne Fleur Kortekaas-Rijlaarsdam1, Marjolein Luman1, Edmund Sonuga-Barke2, Jaap Oosterlaan1
1Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
2Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, England, UK

Tóm tắt

Academic improvement is amongst the most common treatment targets when prescribing stimulants to children with ADHD. Previous reviews on stimulant-related academic improvements are inconclusive and focus on task engagement. Recent literature suggests outcome-domain-specific medication effects that are larger for productivity than for accuracy. The aims of this study are quantifying methylphenidate effects on academic productivity and accuracy for math, reading, spelling; exploring the mediating or moderating effects of symptom improvements, demographic-, design- and disorder-related variables. PubMed, EMBASE, ERIC and PsycINFO were searched for articles reporting methylphenidate effects on academic productivity and accuracy. Thirty-four studies met entry criteria. Methylphenidate improved math productivity (7.8% increase, p < .001); math accuracy (3.0% increase, p = .001); increased reading speed (SMD .47, p < .001) but not reading accuracy. None of the mediators or moderators tested affected methylphenidate efficacy. Academic improvements were small compared to symptom improvements; qualitative changes limited to math. Clinicians should take this discrepancy into account when prescribing medication for ADHD.

Tài liệu tham khảo

Barry TD, Lyman RD, Klinger LG (2002) Academic underachievement and attention-deficit/hyperactivity disorder: the negative impact of symptom severity on school performance. J School Psychol 40:259–283

Polderman TJC, Boomsma DI, Bartels M et al (2010) A systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatr Scand 122:271–284. https://doi.org/10.1111/j.1600-0447.2010.01568.x

Frazier TW, Youngstrom EA, Glutting JJ, Watkins MW (2007) ADHD and achievement: meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students. J Learn Disabil 40:49–65. https://doi.org/10.1177/00222194070400010401

Wright N, Moldavsky M, Schneider J et al (2015) Practitioner review: pathways to care for ADHD—a systematic review of barriers and facilitators. J Child Psychol Psychiatry 56:598–617. https://doi.org/10.1111/jcpp.12398

Coghill DR, Seth S, Pedroso S et al (2013) Effects of methylphenidate on cognitive functions in children and adolescents with attention-deficit/hyperactivity disorder: evidence from a systematic review and a meta-analysis. Biol Psychiatry. https://doi.org/10.1016/j.biopsych.2013.10.005

Barkley RA (1977) A review of stimulant drug research with hyperactive children. J Child Psychol Psychiatry 18:137–165

Schachar R, Tannock R (1993) Hyperactivity and psychostimulant: of extended treatment studies a review. J Child Adolesc Psychopharmacol 3:81–97

Arnold LE, Hodgkins P, Kahle J et al (2015) Long-term outcomes of ADHD: academic achievement and performance. J Attent Disord. https://doi.org/10.1177/1087054714566076

Kortekaas-Rijlaarsdam AF, Luman M, Sonuga-Barke E et al (2017) Short-term effects of methylphenidate on math productivity in children with attention-deficit/hyperactivity disorder are mediated by symptom improvements: evidence from a placebo-controlled trial. J Clin Psychopharmacol 37:210–219

GetData GRaph Digitizer [Computer software] (2013). Retrieved from http://getdata-graphdigitizer.com

Pelham WE, Gnagy EM, Burrows-Maclean L et al (2001) Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics 107:E105. https://doi.org/10.1542/peds.107.6.e105

Armstrong RB, Damaraju CV, Ascher S et al (2012) Time course of treatment effect of OROS(registered trademark) methylphenidate in children with ADHD. J Atten Disord 16:697–705

Forness SR, Swanson JM, Cantwell DP et al (1992) Stimulant medication and reading performance: follow-up on sustained dose in ADHD boys with and without conduct disorders. J Learn Disabil 25:115–123

Douglas VI, Barr RG, O’Neill ME, Britton BG (1986) Short term effects of methylphenidate on the cognitive, learning and academic performance of children with attention deficit disorder in the laboratory and the classroom. J Child Psychol Psychiatry Allied Discip 27:191–211

Pelham WE, Bender ME, Caddell J (1985) Methylphenidate and children with attention deficit disorder. Dose effects on classroom academic and social behavior. Arch Gen Psychiatry 42:948–952

Borenstein M, Hedges L, Higgins J, Rothstein H (2009) Introduction to meta-analysis. Wiley, Chichester

Swanson J, Schuck S, Mann M, et al (1994) Categorical and dimensional definitions and evaluations of symptoms of ADHD. The SNAP and SWAN ratings scales [Draft]. pp 1–20. http://www.adhd.net/SNAP_SWAN.pdf. Accessed 14 Apr 2014

Hay DA, Bennett KS, Levy F et al (2007) A twin study of attention-deficit/hyperactivity disorder dimensions rated by the strengths and weaknesses of ADHD-symptoms and normal-behavior (SWAN) scale. Biol Psychiatry 61:700–705. https://doi.org/10.1016/j.biopsych.2006.04.040

Conners CK (1997) Conners’ global index-teacher. Multihealth Systems Inc., North Tonawanda, NY

IBM (2012) IBM SPSS statistics for windows, version 21.0

Borenstein M (2014) Comprehensive meta-analysis V3.0

Twisk JWR (2010) Introduction in applied biostatistics (Inleiding in de toegepaste biostatistiek). Reed Business, Amsterdam

Rosenthal R (1995) Writing meta-analytic reviews. Psychol Bull 118:183–192. https://doi.org/10.1037/0033-2909.118.2.183

Higgins J, Green S (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]

Ioannidis JPA, Patsopoulos NA, Evangelou E (2007) Uncertainty in heterogeneity estimates in meta-analyses. BMJ 335:914–916. https://doi.org/10.1136/bmj.39343.408449.80

Mayes SD, Calhoun SL (2007) Learning, attention, writing, and processing speed in typical children and children with ADHD, autism, anxiety, depression, and oppositional-defiant disorder. Child Neuropsychol 13:469–493. https://doi.org/10.1080/09297040601112773

Preston AS, Heaton SC, McCann SJ et al (2009) The role of multidimensional attentional abilities in academic skills of children with ADHD. J Learn Disabil 42:240–249. https://doi.org/10.1177/0022219408331042

Thorell LB (2007) Do delay aversion and executive function deficits make distinct contributions to the functional impact of ADHD symptoms? A study of early academic skill deficits. J Child Psychol Psychiatry Allied Discip 48:1061–1070. https://doi.org/10.1111/j.1469-7610.2007.01777.x

Biederman J, Monuteaux MC, Doyle AE et al (2004) Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in children. J Consult Clin Psychol 72:757–766. https://doi.org/10.1037/0022-006X.72.5.757

Coghill DR, Hayward D, Rhodes SM et al (2014) A longitudinal examination of neuropsychological and clinical functioning in boys with attention deficit hyperactivity disorder (ADHD): improvements in executive functioning do not explain clinical improvement. Psychol Med 44:1087–1099. https://doi.org/10.1017/S0033291713001761

Storebø O, Krogh H, Ramstad E et al (2015) Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Br Med J 351:1–14. https://doi.org/10.1136/bmj.h5203