Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Journal of Medicinal Chemistry - Tập 51 Số 18 - Trang 5843-5855 - 2008
Vincenzo Summa1, Alessia Petrocchi1, Fabio Bonelli1, Benedetta Crescenzi1, Monica Donghi1, Marco Ferrara1, F. Fiore1, Cristina Gardelli1, Odalys Gonzalez Paz1, Daria J. Hazuda1, Philip S. Jones1, Olaf Kinzel1, Ralph Laufer1, Edith Monteagudo1, Ester Muraglia1, Emanuela Nizi1, Federica Orvieto1, Paola Pace1, Giovanna Pescatore1, Rita Scarpelli1, Kara A. Stillmock1, Marc Witmer1, Michael Rowley1
1Istituto Di Ricerche Di Biologia Molecolare, P. Angeletti SpA (Merck Research Laboratories, Rome), Via Pontina Km 30,600, 00040 Pomezia, Italy, Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania

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