Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Bioorganic & Medicinal Chemistry Letters - Tập 23 Số 13 - Trang 3741-3748 - 2013
Pascal Furet1, Vito Guagnano1, Robin A. Fairhurst1, Patricia Imbach‐Weese1, Ian C. Bruce1, Mark Knapp1, Christine Fritsch1, Francesca Blasco1, Joachim Blanz1, Reiner Aichholz1, Jacques Hamon1, Doriano Fabbro1, Giorgio Caravatti1
1Novartis Institutes for BioMedical Research, WKL-136.4.12, CH-4002 Basel, Switzerland.

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Fritsch, C. et al. in preparation.