Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer

10.1038/nrc2088

10.1023/A:1008209720526

10.1007/s00018-008-7440-8

10.1158/1078-0432.CCR-05-1554

10.1016/j.apsb.2019.06.010

10.1021/acs.jmedchem.7b01310

10.1021/acs.jmedchem.5b00840

10.1002/anie.202003500

10.1021/acs.jmedchem.9b01566

10.1016/j.ejmech.2020.112199

10.1038/s41392-020-00251-2

10.1056/NEJMoa040938

10.1126/science.1101637

10.1001/jamaoncol.2020.1250

10.1073/pnas.0710370104

10.1073/pnas.0709662105

10.1093/annonc/mdx703

10.1016/S1470-2045(12)70087-6

10.1007/s10549-012-2126-1

10.1007/s40265-018-1028-x

10.1016/j.ctrv.2014.06.010

10.1056/NEJMoa1413654

10.1056/NEJMoa2027071

10.1021/acs.jmedchem.0c00891

10.1093/annonc/mdw129

10.1021/acs.jmedchem.9b01169

10.1021/acs.jmedchem.9b00576

10.1021/acs.jmedchem.7b00515

10.1021/acs.jmedchem.7b00316

10.1021/acs.jmedchem.0c00200

10.1021/acs.jmedchem.5b01633

10.1021/jm500973a

10.1158/2159-8290.CD-14-0337

10.1124/dmd.115.069203

10.1158/1078-0432.CCR-16-1773

10.1021/jm4007998

10.1021/jm1010995

10.1021/jm901023f

10.1021/jm400032t

Chang, J.; Du, J. 2-(2,4,5-Substituted Phenylamino) Pyrimidine Derivatives, Preparation Method and Application in Preparation of Antitumor Drugs. CN Patent ZL201711282598.8, Aug 27, 2019.

Cheng, C.; Wen, S.; Li, H. J. Fluorine and/or Deuterium-Containing Compounds for The Treatment of Non-Small Cell Lung Cancer and Related Diseases. U.S. Patent US20190169171, April 28, 2020.

10.1021/acs.jmedchem.8b00346

10.1177/1087057112463732