Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

Journal of Medicinal Chemistry - Tập 51 Số 5 - Trang 1145-1149 - 2008
Wei Meng1, Bruce A. Ellsworth1, Alexandra A. Nirschl1, Peggy J. McCann1, Manorama M. Patel1, Ravindar N. Girotra1, Gang Wu1, Philip M. Sher1, Eamonn P. Morrison1, Scott A. Biller1, Robert Zahler1, Prashant P. Deshpande1, Annie Pullockaran1, Deborah Hagan1, Nathan Morgan1, Joseph R. Taylor1, Mary T. Obermeier1, W. Griffith Humphreys1, Ashish K. Khanna1, Lorell Discenza1, James G. Robertson1, Wang Aiying1, Song‐Ping Han1, John R. Wetterau1, Evan B. Janovitz1, Oliver Flint1, Jean M. Whaley1, William N. Washburn1
1Metabolic Diseases Chemistry, Process R & D, Metabolic Diseases Biology, Pharmacological Candidate Optimization, Drug Safety Evaluation, Research and Development, Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08543

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