Dipeptidyl peptidase-4 inhibitors and heart failure: A meta-analysis of randomized clinical trials

Nutrition, Metabolism and Cardiovascular Diseases - Tập 24 - Trang 689-697 - 2014
M. Monami1, I. Dicembrini2,3, E. Mannucci3
1Section of Geriatric and Medicine, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy
2Obesity Agency, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy
3Diabetes Agency, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy

Tài liệu tham khảo

Inzucchi, 2012, Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), Diabetes Care, 35, 1364, 10.2337/dc12-0413 White, 2013, Alogliptin after acute coronary syndrome in patients with type 2 diabetes, N Engl J Med, 369, 1327, 10.1056/NEJMoa1305889 Scirica, 2013, SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus, N Engl J Med, 369, 1317, 10.1056/NEJMoa1307684 Jadad, 1996, Assessing the quality of reports of randomized clinical trials: is blinding necessary?, Control Clin Trials, 17, 1, 10.1016/0197-2456(95)00134-4 Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557 Begg, 1994, Operating characteristics of a rank correlation test for publication bias, Biometrics, 50, 1088, 10.2307/2533446 Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, BMJ, 315, 629, 10.1136/bmj.315.7109.629 Moher, 2009, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Ann Intern Med, 151, 264, 10.7326/0003-4819-151-4-200908180-00135 Scirica BM, Raz I, Cavender MA, Steg PG, Hirshberg B, Davidson J, et al., on behalf of the SAVOR-TIMI 53 Steering Committee and Investigators. Outcomes of patients with type 2 diabetes and known congestive heart failure treated with saxagliptin: Analyses of the SAVOR-TIMI 53 Study. Poster number 5082 presented at American Heart Association 2013, Dallas, Texas, USA on 17th November 2013. Sokos, 2006, Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure, J Card Fail, 12, 694, 10.1016/j.cardfail.2006.08.211 Nikolaidis, 2005, Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy, Am J Physiol Heart Circ Physiol, 289, H2401, 10.1152/ajpheart.00347.2005 Read, 2011, A pilot study to assess whether glucagon-like peptide-1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans, Circ Cardiovasc Interv, 4, 266, 10.1161/CIRCINTERVENTIONS.110.960476 Read, 2010, DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease, Circ Cardiovasc Imaging, 3, 195, 10.1161/CIRCIMAGING.109.899377 Ban, 2010, Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor, Endocrinology, 151, 1520, 10.1210/en.2009-1197 Pratley, 2009, Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy, Obes Metab, 11, 167, 10.1111/j.1463-1326.2008.01016.x DeFronzo, 2008, Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study, Diabetes Care, 31, 2315, 10.2337/dc08-1035 Nauck, 2009, Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study, Int J Clin Pract, 63, 46, 10.1111/j.1742-1241.2008.01933.x Rosenstock, 2010, Initial combination therapy with alogliptin and pioglitazone in drug-naïve patients with type 2 diabetes, Diabetes Care, 33, 2406, 10.2337/dc10-0159 Gomis, 2011, Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study, Diabetes Obes Metab, 13, 653, 10.1111/j.1463-1326.2011.01391.x Taskinen, 2011, Safety and efficacy of linagliptin as add- on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study, Diabetes Obes Metab, 13, 65, 10.1111/j.1463-1326.2010.01326.x Del Prato, 2011, Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial, Diabetes Obes Metab, 13, 258, 10.1111/j.1463-1326.2010.01350.x Owens, 2011, Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study, Diabet Med, 28, 1352, 10.1111/j.1464-5491.2011.03387.x Haak, 2012, Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study, Diabetes Obes Metab, 14, 565, 10.1111/j.1463-1326.2012.01590.x Kawamori, 2012, Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study, Diabetes Obes Metab, 14, 348, 10.1111/j.1463-1326.2011.01545.x Gallwitz, 2012, 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial, Lancet, 380, 475, 10.1016/S0140-6736(12)60691-6 Pfützner, 2011, Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks, Diabetes Obes Metab, 13, 567, 10.1111/j.1463-1326.2011.01385.x Yang, 2011, Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial, Diabetes Res Clin Pract, 94, 217, 10.1016/j.diabres.2011.07.035 Pan, 2012, Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial, Diabetes Metab Res Rev, 28, 268, 10.1002/dmrr.1306 Rosenstock, 2009, Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes, Curr Med Res Opin, 25, 2401, 10.1185/03007990903178735 Hollander, 2011, Safety and efficacy of saxagliptin added to thiazolidinedione over 76 weeks in patients with type 2 diabetes mellitus, Diab Vasc Dis Res, 8, 125, 10.1177/1479164111404575 Chacra, 2011, Safety and efficacy of saxagliptin in combination with submaximal sulphonylurea versus up-titrated sulphonylurea over 76 weeks, Diab Vasc Dis Res, 8, 150, 10.1177/1479164111404574 Barzilai, 2011, Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial, Curr Med Res Opin, 27, 1049, 10.1185/03007995.2011.568059 Hermansen, 2007, Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin, Diabetes Obes Metab, 9, 733, 10.1111/j.1463-1326.2007.00744.x Yoon, 2011, Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and pioglitazone on glycemic control and measures of beta-cell function in patients with type 2 diabetes, Int J Clin Pract, 65, 154, 10.1111/j.1742-1241.2010.02589.x Vilsbøll, 2010, Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes, Diabetes Obes Metab, 12, 167, 10.1111/j.1463-1326.2009.01173.x Charbonnel, 2006, Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone, Diabetes Care, 29, 2638, 10.2337/dc06-0706 Rosenstock, 2006, Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo- controlled, parallel-group study, Clin Ther, 28, 1556, 10.1016/j.clinthera.2006.10.007 Aschner, 2006, Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes, Diabetes Care, 29, 2632, 10.2337/dc06-0703 Fonseca, 2013, Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetes, J Diabetes Complicat, 27, 177, 10.1016/j.jdiacomp.2012.09.007 Bergenstal, 2010, Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial, Lancet, 376, 431, 10.1016/S0140-6736(10)60590-9 Raz, 2008, Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes, Curr Med Res Opin, 24, 537, 10.1185/030079908X260925 Arechavaleta, 2011, Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial, Diabetes Obes Metab, 13, 160, 10.1111/j.1463-1326.2010.01334.x Wainstein, 2012, Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes, Diabetes Obes Metab, 14, 409, 10.1111/j.1463-1326.2011.01530.x Raz, 2006, Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus, Diabetologia, 49, 2564, 10.1007/s00125-006-0416-z Arjona Ferreira, 2013, Efficacy and safety of sitagliptin in patients with type 2 diabetes and ESRD receiving dialysis: a 54-week randomized trial, Am J Kidney Dis, 61, 579, 10.1053/j.ajkd.2012.11.043 Dobs, 2013, Efficacy and safety of sitagliptin added to ongoing metformin and rosiglitazone combination therapy in a randomized placebo-controlled 54-week trial in patients with type 2 diabetes, J Diabetes, 5, 68, 10.1111/j.1753-0407.2012.00223.x Chan, 2008, Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency, Diabetes Obes Metab, 10, 545, 10.1111/j.1463-1326.2008.00914.x Williams-Herman, 2010, Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes, Diabetes Obes Metab, 12, 442, 10.1111/j.1463-1326.2010.01204.x Seck, 2010, Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study, Int J Clin Pract, 64, 562, 10.1111/j.1742-1241.2010.02353.x Strain, 2013, Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study, Lancet, 382, 409, 10.1016/S0140-6736(13)60995-2 Fonseca, 2007, Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes, Diabetologia, 50, 1148, 10.1007/s00125-007-0633-0 Pan, 2012, Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus, Diabetes Obes Metab, 14, 737, 10.1111/j.1463-1326.2012.01593.x Pan, 2008, Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial, Diabet Med, 25, 435, 10.1111/j.1464-5491.2008.02391.x Dejager, 2007, Vildagliptin in drug-naïve patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study, Horm Metab Res, 39, 218, 10.1055/s-2007-970422 Scherbaum, 2008, Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia, Diabetes Obes Metab, 10, 675, 10.1111/j.1463-1326.2008.00850.x Bolli, 2009, Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin, Diabetes Obes Metab, 11, 589, 10.1111/j.1463-1326.2008.01023.x Ferrannini, 2009, Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy, Diabetes Obes Metab, 11, 157, 10.1111/j.1463-1326.2008.00994.x Rosenstock, 2009, Long-term 2-year safety and efficacy of vildagliptin compared with rosiglitazone in drug-naïve patients with type 2 diabetes mellitus, Diabetes Obes Metab, 11, 571, 10.1111/j.1463-1326.2008.01021.x Foley, 2009, Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes, Horm Metab Res, 41, 905, 10.1055/s-0029-1234042