Phạm Hải Yến1, Nguyen Huy Hoang1, Nguyễn Xuân Nhiệm1, Phan Thị Thanh Hương1, Dương Thị Dung1, Nguyễn Thị Cúc1, Nguyen The Cuong2, Bùi Văn Thanh2, Bùi Hữu Tài1, Phan Văn Kiệm1
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
2Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072 Vietnam
Tóm tắt
AbstractFrom the fruits of Schisandra cauliflora, five new dimethylbutyrylated dibenzocyclooctadiene lignans, named schisandracaurins A−E, were isolated using separation and chromatographic techniques. Their structures were determined by extensive analyses of HR‐ESI‐MS, NMR, and ECD spectra. The schisandracaurins A−E potentially inhibited NO production in LPS‐activated RAW264.7 cells with their IC50 values from 21.4 to 30.3 μM.
