Diethylstilbestrol‐diphosphate induces chromosomal aberrations but not sister chromatid exchanges in murine bone marrow cells in vivo

Wiley - Tập 3 Số 4 - Trang 445-452 - 1981
James L. Ivett1, Raymond R. Tice2
1Department of Genetics, North Carolina State University, Raleigh, New York
2Medical Department, Brookhaven National Laboratory, Upton, NY 11973

Tóm tắt

AbstractDiethylstilbestrol diphosphate (DES‐dp) clastogenesis was examined in the bone marrow of C57B1/6 male and female mice. Significant and sex‐related dose effects were observed for the induction of chromatid‐type chromosomal aberrations and for the inhibition of cellular proliferation. Females were more sensitive to the effects of DES‐dp than males when assessed for either induced chromosomal aberrations or proliferative inhibition. Contrary to other published results, we did not observe either an increase in sister chromatid exchanges or an increased incidence of aneuploidy. Ovariectomy reduced the ability of DES‐dp to inhibit cellular proliferation and decreased the high degree of variability between animals at high doses of DES‐dp. The results of our studies show that DES is a clastogenic agent in vivo which may relate to its carcinogenicity.

Từ khóa


Tài liệu tham khảo

10.1093/jnci/58.6.1635

10.1042/bj1580643

10.1002/tera.1420090215

10.1139/g74-089

Chrisman CL, 1975, Effect of diethylstilbestrol diphosphate on mitotic activity in bovine lymphocyte cultures, Cytologia, 40, 817, 10.1508/cytologia.40.817

Dunn T, 1963, Cysts of the epididymis, cancer of the cervix, granular cell myoblastoma and other lesions after estrogen injection in newborn mice, J Natl Cancer Inst, 31, 425

10.1007/BF00329173

10.1056/NEJM197104222841604

10.1016/0027-5107(77)90177-4

Martin CN, 1978, Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells, Cancer Res, 38, 2621

10.1080/15287397709529453

10.1126/science.242076

10.1016/0006-2952(75)90373-1

10.1016/0006-291X(78)90625-3

10.1007/BF00343272

10.1016/0014-4827(67)90277-7

10.1016/0147-6513(79)90004-6

10.1038/281392a0

10.1016/0027-5107(78)90265-8

10.1073/pnas.74.5.2041

Shah HC, 1976, The fate of diethylstilbestrol in the pregnant mouse, J Pharmacol Exp Ther, 197, 687

10.1016/0165-1218(78)90022-8

10.1016/0014-4827(76)90037-9

Thông tin
Thông tin xuất bản

Wiley

Tập 3 Số 4

445-452

Thông tin tác giả