Dietary nutraceuticals as backbone for bone health
Tài liệu tham khảo
Abdi, 2016, Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials, Climacteric, 19, 535, 10.1080/13697137.2016.1238451
Adler, 2014, Osteoporosis in men: a review, Bone Res, 2, 14001, 10.1038/boneres.2014.1
Aggarwal, 2004, Nuclear factor-kappaB: the enemy within, Cancer Cell, 6, 203, 10.1016/j.ccr.2004.09.003
Aggarwal B.B., S., S., Surh Y.J., 2006. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease.
Ahn, 2006, Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway, Mol. Cancer Res., 4, 621, 10.1158/1541-7786.MCR-06-0076
Ahn, 2008, Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway, Int. J. Cancer, 123, 1733, 10.1002/ijc.23745
An, 2016, Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation, Life Sci., 147, 46, 10.1016/j.lfs.2016.01.024
Ardawi, 2016, Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model, Bone, 83, 127, 10.1016/j.bone.2015.10.017
Armstrong, 2002, A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function, J. Biol. Chem., 277, 44347, 10.1074/jbc.M202009200
Atbinici, 2015, Effects of salmon calcitonin treatment on serum and synovial fluid bone formation and resorption markers in osteoporosis patients, Acta Orthop. Traumatol. Turc., 49, 160
Aubin, 2004, In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis, Genes Dev., 18, 1482, 10.1101/gad.1202604
Balemans, 2007, Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling, J. Bone Miner. Res., 22, 708, 10.1359/jbmr.070211
Bandeira, 2016, Pharmacodynamics and pharmacokinetics of oral salmon calcitonin in the treatment of osteoporosis, Expert Opin. Drug Metab. Toxicol., 12, 681, 10.1080/17425255.2016.1175436
Bandyopadhyay, 2006, Attenuation of osteoclastogenesis and osteoclast function by apigenin, Biochem. Pharmacol., 72, 184, 10.1016/j.bcp.2006.04.018
Baron, 2013, WNT signaling in bone homeostasis and disease: from human mutations to treatments, Nat. Med., 19, 179, 10.1038/nm.3074
Beekman, 2017, The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis, Bone, 10.1016/j.bone.2017.10.011
Belcaro, 2010, Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients, Altern. Med. Rev., 15, 337
Bharti, 2004, Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis, J. Immunol., 172, 5940, 10.4049/jimmunol.172.10.5940
Bian, 2012, Oleanolic acid exerts an osteoprotective effect in ovariectomy-induced osteoporotic rats and stimulates the osteoblastic differentiation of bone mesenchymal stem cells in vitro, Menopause, 19, 225, 10.1097/gme.0b013e3182272ef1
Binkley, 2014, Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial, Osteoporos. Int., 25, 2649, 10.1007/s00198-014-2796-0
Boggon, 2004, Structure and regulation of Src family kinases, Oncogene, 23, 7918, 10.1038/sj.onc.1208081
Boyce, 2013, Advances in the regulation of osteoclasts and osteoclast functions, J. Dent. Res., 92, 860, 10.1177/0022034513500306
Boyce, 2007, Biology of RANK, RANKL, and osteoprotegerin, Arthritis Res Ther, 9, S1, 10.1186/ar2165
Boyce, 2015, NF-kappaB-Mediated Regulation of Osteoclastogenesis, Endocrinol Metab (Seoul), 30, 35, 10.3803/EnM.2015.30.1.35
Boyle, 2003, Osteoclast differentiation and activation, Nature, 423, 337, 10.1038/nature01658
Broege, 2013, Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis, J. Biol. Chem., 288, 37230, 10.1074/jbc.M113.496950
Burgers, 2013, Regulation of Wnt/beta-catenin signaling within and from osteocytes, Bone, 54, 244, 10.1016/j.bone.2013.02.022
Cai, 2016, Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling, Proc. Natl. Acad. Sci. U. S. A., 113, 14751, 10.1073/pnas.1612520114
Canalis, 2018, MANAGEMENT OF ENDOCRINE DISEASE: Novel Anabolic Treatments for Osteoporosis, Eur. J. Endocrinol., 178, R33, 10.1530/EJE-17-0920
Cappellen, 2002, Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B, J. Biol. Chem., 277, 21971, 10.1074/jbc.M200434200
Casado-Diaz, 2016, Effects of quercetin, a natural phenolic compound, in the differentiation of human mesenchymal stem cells (MSC) into adipocytes and osteoblasts, J. Nutr. Biochem., 32, 151, 10.1016/j.jnutbio.2016.03.005
Chambers, 2000, Regulation of the differentiation and function of osteoclasts, J. Pathol., 192, 4, 10.1002/1096-9896(2000)9999:9999<::AID-PATH645>3.0.CO;2-Q
Chandran, 2012, A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis, Phytother. Res., 26, 1719, 10.1002/ptr.4639
Chen, 2010, Breast cancer metastasis to the bone: mechanisms of bone loss, Breast Cancer Res., 12, 215, 10.1186/bcr2781
Chen, 2012, TGF-beta and BMP signaling in osteoblast differentiation and bone formation, Int. J. Biol. Sci., 8, 272, 10.7150/ijbs.2929
Chen, 2016, Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway, Int. J. Mol. Med., 37, 329, 10.3892/ijmm.2015.2432
Chen, 2017, Emodin suppresses cadmium-induced osteoporosis by inhibiting osteoclast formation, Environ. Toxicol. Pharmacol., 54, 162, 10.1016/j.etap.2017.07.007
Cheung, 2006, A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene, Bone, 39, 470, 10.1016/j.bone.2006.02.069
Chin, 2016, The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis, Drug Des Devel Ther, 10, 3029, 10.2147/DDDT.S117432
Choi, 2011, Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators, Int. Immunopharmacol., 11, 1541, 10.1016/j.intimp.2011.05.011
Choi, 2012, Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways, Evid. Based Complement. Alternat. Med., 2012, 810563, 10.1155/2012/810563
Chung, 2001, Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development, J. Clin. Invest., 107, 295, 10.1172/JCI11706
Chung, 2017, Anti-Osteoporotic Activity of Harpagoside by Upregulation of the BMP2 and Wnt Signaling Pathways in Osteoblasts and Suppression of Differentiation in Osteoclasts, J. Nat. Prod., 80, 434, 10.1021/acs.jnatprod.6b00964
Clementini, 2014, Systemic risk factors for peri-implant bone loss: a systematic review and meta-analysis, Int. J. Oral Maxillofac. Surg., 43, 323, 10.1016/j.ijom.2013.11.012
Cotter, 2003, Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement therapy, Nutr. Rev., 61, 346, 10.1301/nr.2003.oct.346-351
Crasto, 2013, Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity, J. Cell. Biochem., 114, 929, 10.1002/jcb.24434
Cummings, 2018, Vertebral Fractures Following Discontinuation of Denosumab: a Post-hoc Analysis of the Randomized Placebo-controlled FREEDOM Trial and its Extension, J. Bone Miner. Res., 33, 190, 10.1002/jbmr.3337
Dai, 2013, Genistein promotion of osteogenic differentiation through BMP2/SMAD5/RUNX2 signaling, Int. J. Biol. Sci., 9, 1089, 10.7150/ijbs.7367
Daily, 2016, Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, J. Med. Food, 19, 717, 10.1089/jmf.2016.3705
Darnay, 1998, Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase, J. Biol. Chem., 273, 20551, 10.1074/jbc.273.32.20551
Das, 2013, Osteoporosis - a current view of pharmacological prevention and treatment, Drug Des Devel Ther, 7, 435
Dathe, 2009, Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2, Am. J. Hum. Genet., 84, 483, 10.1016/j.ajhg.2009.03.001
Day, 2005, Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis, Dev. Cell, 8, 739, 10.1016/j.devcel.2005.03.016
Deepak, 2015, Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-kappaB and MAPK pathways, Connect. Tissue Res., 56, 195, 10.3109/03008207.2014.989320
Deepak, 2015, Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis, Biofactors, 41, 403, 10.1002/biof.1241
Dempster, 2018, Remodeling- and Modeling-Based Bone Formation with Teriparatide versus Denosumab: A Longitudinal Analysis from Baseline to 3 Months in the AVA Study, J. Bone Miner. Res., 33, 298, 10.1002/jbmr.3309
Deng, 2014, gamma-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor, Bone, 67, 200, 10.1016/j.bone.2014.07.006
Derakhshanian, 2013, Quercetin prevents experimental glucocorticoid-induced osteoporosis: a comparative study with alendronate, Can. J. Physiol. Pharmacol., 91, 380, 10.1139/cjpp-2012-0190
Derynck, 2003, Smad-dependent and Smad-independent pathways in TGF-beta family signalling, Nature, 425, 577, 10.1038/nature02006
Destaing, 2008, The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts, Mol. Biol. Cell, 19, 394, 10.1091/mbc.e07-03-0227
Dong, 2010, 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis, Biochem. Pharmacol., 79, 715, 10.1016/j.bcp.2009.10.010
Dosier, 2012, Resveratrol effect on osteogenic differentiation of rat and human adipose derived stem cells in a 3-D culture environment, J. Mech. Behav. Biomed. Mater., 11, 112, 10.1016/j.jmbbm.2011.08.014
Dougall, 1999, RANK is essential for osteoclast and lymph node development, Genes Dev., 13, 2412, 10.1101/gad.13.18.2412
Duan, 2014, Anti-catabolic effect of caffeic acid phenethyl ester, an active component of honeybee propolis on bone loss in ovariectomized mice: a micro-computed tomography study and histological analysis, Chin. Med. J., 127, 3932
Edwards, 2008, Eph receptors and ephrin signaling pathways: a role in bone homeostasis, Int. J. Med. Sci., 5, 263, 10.7150/ijms.5.263
Fan, 2015, The effects of 6-gingerol on proliferation, differentiation, and maturation of osteoblast-like MG-63 cells, Braz. J. Med. Biol. Res., 48, 637, 10.1590/1414-431X20154494
Feng, 2013, Osteoclasts: New Insights, Bone Res, 1, 11, 10.4248/BR201301003
Fernandez-Garcia, 2008, Effects of raloxifene therapy on circulating osteoprotegerin and RANK ligand levels in post-menopausal osteoporosis, J. Endocrinol. Investig., 31, 416, 10.1007/BF03346385
Franceschi, 2003, Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation, Connect. Tissue Res., 44, 109, 10.1080/03008200390152188
Franzoso, 1997, Requirement for NF-kappaB in osteoclast and B-cell development, Genes Dev., 11, 3482, 10.1101/gad.11.24.3482
Gao, 2017, Effect of zoledronic acid on reducing femoral bone mineral density loss following total hip arthroplasty: A meta-analysis from randomized controlled trails, Int. J. Surg., 47, 116, 10.1016/j.ijsu.2017.08.559
Glass, 2005, Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation, Dev. Cell, 8, 751, 10.1016/j.devcel.2005.02.017
Goetz, 2017, Cross-sex testosterone therapy in ovariectomized mice: addition of low-dose estrogen preserves bone architecture, Am. J. Physiol. Endocrinol. Metab., 313, E540, 10.1152/ajpendo.00161.2017
Gomes-Filho, 2015, Raloxifene modulates regulators of osteoclastogenesis and angiogenesis in an oestrogen deficiency periapical lesion model, Int. Endod. J., 48, 1059, 10.1111/iej.12403
Gomez-Florit, 2015, Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells, Sci. Rep., 5, 16593, 10.1038/srep16593
Goto, 2015, Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice, Cytotechnology, 67, 357, 10.1007/s10616-014-9694-3
Greenspan, 2018, Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur, Osteoporos. Int., 29, 501, 10.1007/s00198-017-4286-7
Grigg, 2017, An individualised risk-adapted protocol of pre- and post transplant zoledronic acid reduces bone loss after allogeneic stem cell transplantation: results of a phase II prospective trial, Bone Marrow Transplant., 52, 1288, 10.1038/bmt.2017.108
Gu, 2012, Curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation, Pharmacogn. Mag., 8, 202, 10.4103/0973-1296.99285
Guo, 2012, Quercetin triggers apoptosis of lipopolysaccharide (LPS)-induced osteoclasts and inhibits bone resorption in RAW264.7 cells, Cell. Physiol. Biochem., 30, 123, 10.1159/000339052
Hasegawa, 2010, Honokiol inhibits osteoclast differentiation and function in vitro, Biol. Pharm. Bull., 33, 487, 10.1248/bpb.33.487
Hayden, 2008, Shared principles in NF-kappaB signaling, Cell, 132, 344, 10.1016/j.cell.2008.01.020
Heim, 2004, The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells, Endocrinology, 145, 848, 10.1210/en.2003-1014
Henrotin, 2014, Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial, BMC Complement. Altern. Med., 14, 159, 10.1186/1472-6882-14-159
Hill, 2005, Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes, Dev. Cell, 8, 727, 10.1016/j.devcel.2005.02.013
Hou, 2016, Curcumin attenuates osteogenic differentiation and calcification of rat vascular smooth muscle cells, Mol. Cell. Biochem., 420, 151, 10.1007/s11010-016-2778-y
Hsu, 2011, Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expression, J. Rheumatol., 38, 1844, 10.3899/jrheum.101223
Hu, 2008, Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways, Eur. J. Pharmacol., 580, 70, 10.1016/j.ejphar.2007.11.013
Hu, 2017, Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway, Acta Biomater., 48, 479, 10.1016/j.actbio.2016.11.022
Ichikawa, 2006, Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation, Clin. Cancer Res., 12, 662, 10.1158/1078-0432.CCR-05-1749
Ichikawa, 2006, 1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation, Mol. Cancer Res., 4, 275, 10.1158/1541-7786.MCR-05-0227
Ichikawa, 2006, Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression, Clin. Cancer Res., 12, 5910, 10.1158/1078-0432.CCR-06-0916
Ichikawa, 2006, Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression, Mol. Cancer Ther., 5, 1434, 10.1158/1535-7163.MCT-06-0096
Ichikawa, 2007, Anticancer drugs designed by mother nature: ancient drugs but modern targets, Curr. Pharm. Des., 13, 3400, 10.2174/138161207782360492
Iimura, 2014, Lycopene intake facilitates the increase of bone mineral density in growing female rats, J. Nutr. Sci. Vitaminol. (Tokyo), 60, 101, 10.3177/jnsv.60.101
Iimura, 2015, The protective effect of lycopene intake on bone loss in ovariectomized rats, J. Bone Miner. Metab., 33, 270, 10.1007/s00774-014-0596-4
Im, 2016, Lupeol Isolated from Sorbus commixta Suppresses 1alpha,25-(OH)2D3-Mediated Osteoclast Differentiation and Bone Loss in Vitro and in Vivo, J. Nat. Prod., 79, 412, 10.1021/acs.jnatprod.5b01088
Iniguez-Ariza, 2015, Bone biology, signaling pathways, and therapeutic targets for osteoporosis, Maturitas, 82, 245, 10.1016/j.maturitas.2015.07.003
Iotsova, 1997, Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2, Nat. Med., 3, 1285, 10.1038/nm1197-1285
Jacob, 2006, Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation, Dev. Biol., 296, 315, 10.1016/j.ydbio.2006.05.031
Javed, 2008, Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal, J. Biol. Chem., 283, 8412, 10.1074/jbc.M705578200
Jiang, 2015, Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-kappaB signaling, Biochimie, 111, 107, 10.1016/j.biochi.2015.02.002
Jiang, 2015, Andrographolide Exerts Pro-Osteogenic Effect by Activation of Wnt/beta-Catenin Signaling Pathway in Vitro, Cell. Physiol. Biochem., 36, 2327, 10.1159/000430196
Johnson, 2011, Craniosynostosis, Eur. J. Hum. Genet., 19, 369, 10.1038/ejhg.2010.235
Joo, 2004, Isoflavones extracted from Sophorae fructus upregulate IGF-I and TGF-beta and inhibit osteoclastogenesis in rat bone marrow cells, Arch. Pharm. Res., 27, 99, 10.1007/BF02980054
Kaneko, 2017, Short-term daily teriparatide in patients with rheumatoid arthritis, Mod. Rheumatol., 1
Kang, 2007, Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma, J. Biol. Chem., 282, 14515, 10.1074/jbc.M700030200
Kang, 2014, CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice, Acad. Radiol., 21, 457, 10.1016/j.acra.2013.12.009
Karin, 2002, NF-kappaB at the crossroads of life and death, Nat. Immunol., 3, 221, 10.1038/ni0302-221
Katz, 2013, Targeting TGF-beta signaling in cancer, Expert Opin. Ther. Targets, 17, 743, 10.1517/14728222.2013.782287
Kavitha, 2014, Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-kappaB, and AP-1 activation in RAW264.7 cells, Mol. Carcinog., 53, 169, 10.1002/mc.21959
Ke, 2015, MicroRNA-183 increases osteoclastogenesis by repressing heme oxygenase-1, Bone, 81, 237, 10.1016/j.bone.2015.07.006
Khalid, 2016, Estrogen receptors alpha and beta in bone, Bone, 87, 130, 10.1016/j.bone.2016.03.016
Khanna, 2007, Natural products as a gold mine for arthritis treatment, Curr. Opin. Pharmacol., 7, 344, 10.1016/j.coph.2007.03.002
Khedgikar, 2013, Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone, Cell Death Dis., 4, 10.1038/cddis.2013.294
Kim, 2016, Signaling Pathways in Osteoclast Differentiation, Chonnam Med J, 52, 12, 10.4068/cmj.2016.52.1.12
Kim, 2005, Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis, J. Exp. Med., 202, 589, 10.1084/jem.20050978
Kim, 2005, Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB, Mol. Cell, 20, 364
Kim, 2006, Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells, Biochem. Pharmacol., 72, 1268, 10.1016/j.bcp.2006.08.021
Kim, 2009, Silibinin inhibits osteoclast differentiation mediated by TNF family members, Mol. Cell, 28, 201, 10.1007/s10059-009-0123-y
Kim, 2011, The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss, J. Nutr. Biochem., 22, 8, 10.1016/j.jnutbio.2009.11.002
Kim, 2011, Curcumin protects against ovariectomy-induced bone loss and decreases osteoclastogenesis, J. Cell. Biochem., 112, 3159, 10.1002/jcb.23242
Kim, 2012, Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-kappaB and NF-kappaB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis, Mol. Nutr. Food Res., 56, 454, 10.1002/mnfr.201100270
Kim, 2012, Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts, J. Cell. Biochem., 113, 247, 10.1002/jcb.23351
Kim, 2012, Osteogenic activity of silymarin through enhancement of alkaline phosphatase and osteocalcin in osteoblasts and tibia-fractured mice, Exp Biol Med (Maywood), 237, 417, 10.1258/ebm.2011.011376
Kim, 2014, Inhibitory effects of obovatol on osteoclast differentiation and bone resorption, Eur. J. Pharmacol., 723, 473, 10.1016/j.ejphar.2013.10.027
Kim, 2014, Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages, J. Nutr. Biochem., 25, 295, 10.1016/j.jnutbio.2013.11.003
Kim, 2015, Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs, Mol. Endocrinol., 29, 1498, 10.1210/me.2015-1133
Kim, 2015, Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCgamma2-Ca(2+) Signaling Pathway and Prevents Inflammation-Mediated Bone Loss, J. Nat. Prod., 78, 2167, 10.1021/acs.jnatprod.5b00233
King, 2015, Potential Effects of Phytoestrogen Genistein in Modulating Acute Methotrexate Chemotherapy-Induced Osteoclastogenesis and Bone Damage in Rats, Int. J. Mol. Sci., 16, 18293, 10.3390/ijms160818293
Kling, 2014, Osteoporosis prevention, screening, and treatment: a review, J. Women's Health (Larchmt), 23, 563, 10.1089/jwh.2013.4611
Ko, 2016, Genetic Syndromes Associated with Craniosynostosis, J Korean Neurosurg Soc, 59, 187, 10.3340/jkns.2016.59.3.187
Kobayashi, 2000, Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction, J. Exp. Med., 191, 275, 10.1084/jem.191.2.275
Kobayashi, 2003, Trabecular minimodeling in human iliac bone, Bone, 32, 163, 10.1016/S8756-3282(02)00947-X
Kobayashi, 2012, Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide, ISRN Pharmacol, 2012, 439860, 10.5402/2012/439860
Kochanowska, 2007, Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton, BMC Musculoskelet. Disord., 8, 128, 10.1186/1471-2474-8-128
Kokabu, 2012, BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b, Mol. Endocrinol., 26, 87, 10.1210/me.2011-1168
Kotecha, 2005, Soy-relieving the symptoms of menopause and fighting osteoporosis, Pharm. J., 275, 5
Krishnan, 2006, Regulation of bone mass by Wnt signaling, J. Clin. Invest., 116, 1202, 10.1172/JCI28551
Kunnumakkara, 2007, Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis, Blood, 109, 5112, 10.1182/blood-2007-01-067256
Kunnumakkara, 2008, Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis, Mol. Cancer Ther., 7, 3306, 10.1158/1535-7163.MCT-08-0432
Kushwaha, 2014, A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-beta-catenin signaling, Cell Death Dis., 5, e1422, 10.1038/cddis.2014.350
Kwon, 2016, Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1, J. Nutr. Biochem., 30, 24, 10.1016/j.jnutbio.2015.11.013
Lai, 2005, The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis: a randomized clinical study, JBJS, 87, 2155
Laine, 2011, Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG), Eur. J. Hum. Genet., 19, 875, 10.1038/ejhg.2011.42
Lamb, 2011, Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D(3), and vitamin K(1) produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome, Nutr. Res., 31, 347, 10.1016/j.nutres.2011.03.016
Langdahl, 2017, Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial, Lancet, 390, 1585, 10.1016/S0140-6736(17)31613-6
Lange, 2017, Weekly oral bisphosphonates over 2 years prevent bone loss in cardiac transplant patients, Clin. Transpl., 31, 10.1111/ctr.13122
Lappe, 2013, Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study, Eur. J. Nutr., 52, 203, 10.1007/s00394-012-0304-x
Lee, 2003, BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression, J. Biol. Chem., 278, 34387, 10.1074/jbc.M211386200
Lee, 2008, Berberine promotes osteoblast differentiation by Runx2 activation with p38 MAPK, J. Bone Miner. Res., 23, 1227, 10.1359/jbmr.080325
Lee, 2009, Inhibitory effect of luteolin on osteoclast differentiation and function, Cytotechnology, 61, 125, 10.1007/s10616-010-9253-5
Lee, 2015, Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation, Mol. Nutr. Food Res., 59, 386, 10.1002/mnfr.201400164
Lee, 2017, Effects of Resveratrol Supplementation on Methotrexate Chemotherapy-Induced Bone Loss, Nutrients, 9, 10.3390/nu9030255
Leotoing, 2013, The polyphenol fisetin protects bone by repressing NF-kappaB and MKP-1-dependent signaling pathways in osteoclasts, PLoS One, 8, 10.1371/journal.pone.0068388
Leotoing, 2014, The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity, Mol. Nutr. Food Res., 58, 1239, 10.1002/mnfr.201300836
Li, 2003, Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation, Biol. Pharm. Bull., 26, 780, 10.1248/bpb.26.780
Li, 2012, Plumbagin inhibits breast tumor bone metastasis and osteolysis by modulating the tumor-bone microenvironment, Curr. Mol. Med., 12, 967, 10.2174/156652412802480871
Liang, 2012, Lycopene effects on serum mineral elements and bone strength in rats, Molecules, 17, 7093, 10.3390/molecules17067093
Liao, 2014, Genistein induces oestrogen receptor-alpha gene expression in osteoblasts through the activation of mitogen-activated protein kinases/NF-kappaB/activator protein-1 and promotes cell mineralisation, Br. J. Nutr., 111, 55, 10.1017/S0007114513002043
Lindsay, 1999, Addition of alendronate to ongoing hormone replacement therapy in the treatment of osteoporosis: a randomized, controlled clinical trial, J. Clin. Endocrinol. Metab., 84, 3076
Lisabeth, 2013, Eph receptor signaling and ephrins, Cold Spring Harb. Perspect. Biol., 5, 10.1101/cshperspect.a009159
Liu, 2014, Effect of calcitonin on anastrozole-induced bone pain during aromatase inhibitor therapy for breast cancer, Genet. Mol. Res., 13, 5285, 10.4238/2014.July.24.7
Liu, 2016, Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway, Front. Pharmacol., 7, 375, 10.3389/fphar.2016.00375
Liu, 2016, Wedelolactone enhances osteoblastogenesis by regulating Wnt/beta-catenin signaling pathway but suppresses osteoclastogenesis by NF-kappaB/c-fos/NFATc1 pathway, Sci. Rep., 6
Looker, 2017, FRAX-based estimates of 10-year probability of hip and major osteoporotic fracture among adults aged 40 and over: United States, 2013 and 2014, National health statistics reports, 103, 1
Lu, 2016, Ibandronate for the prevention of bone loss after allogeneic stem cell transplantation for hematologic malignancies: a randomized-controlled trial, BoneKEy reports, 5, 843, 10.1038/bonekey.2016.72
Lu, 2017, Response to teriparatide in Chinese patients with established osteoporosis: osteocalcin and lumbar spine bone-mineral density changes from teriparatide Phase III study, Clin. Interv. Aging, 12, 1717, 10.2147/CIA.S140900
Ma, 2015, Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways, Biochem. J., 469, 399, 10.1042/BJ20150151
Mackinnon, 2011, Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women, Osteoporos. Int., 22, 1091, 10.1007/s00198-010-1308-0
Mandema, 2014, Time course of bone mineral density changes with denosumab compared with other drugs in postmenopausal osteoporosis: a dose-response-based meta-analysis, J. Clin. Endocrinol. Metab., 99, 3746, 10.1210/jc.2013-3795
Manna, 2000, Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation, J. Immunol., 164, 6509, 10.4049/jimmunol.164.12.6509
Maricic, 2007, New and emerging treatments for osteoporosis, Curr. Opin. Rheumatol., 19, 364, 10.1097/BOR.0b013e328172dc1a
Marzia, 2000, Decreased c-Src expression enhances osteoblast differentiation and bone formation, J. Cell Biol., 151, 311, 10.1083/jcb.151.2.311
Masuhara, 2016, A relation between osteoclastogenesis inhibition and membrane-type estrogen receptor GPR30, Biochem Biophys Rep, 8, 389
Matsubara, 2008, BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation, J. Biol. Chem., 283, 29119, 10.1074/jbc.M801774200
Matsuda, 2018, Resveratrol suppresses the alveolar bone resorption induced by artificial trauma from occlusion in mice, Oral Dis., 24, 412, 10.1111/odi.12785
McLean, 2009, Proinflammatory cytokines and osteoporosis, Curr Osteoporos Rep, 7, 134, 10.1007/s11914-009-0023-2
Meier, 2017, Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO, Swiss Med. Wkly., 147
von Metzler, 2009, Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase, J. Cancer Res. Clin. Oncol., 135, 173, 10.1007/s00432-008-0461-8
Ming, 2013, Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling, J. Cell. Physiol., 228, 513, 10.1002/jcp.24158
Miyazaki, 2004, Src kinase activity is essential for osteoclast function, J. Biol. Chem., 279, 17660, 10.1074/jbc.M311032200
Miyazono, 2000, TGF-beta signaling by Smad proteins, Adv. Immunol., 75, 115, 10.1016/S0065-2776(00)75003-6
Mobasheri, 2013, Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis, Ann. N. Y. Acad. Sci., 1290, 59, 10.1111/nyas.12145
Mohd Fozi, 2013, Milk thistle: a future potential anti-osteoporotic and fracture healing agent, Curr. Drug Targets, 14, 1659, 10.2174/13894501113146660222
Monda, 2017, Improvement of Bone Physiology and Life Quality Due to Association of Risedronate and Anastrozole, Front. Pharmacol., 8, 632, 10.3389/fphar.2017.00632
Morabito, 2002, Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study, J. Bone Miner. Res., 17, 1904, 10.1359/jbmr.2002.17.10.1904
Morley, 2001, Parathyroid hormone: an anabolic treatment for osteoporosis, Curr. Pharm. Des., 7, 671, 10.2174/1381612013397780
Mundy, 2008, PTH-related peptide (PTHrP) in hypercalcemia, J. Am. Soc. Nephrol., 19, 672, 10.1681/ASN.2007090981
Nakagawa, 2014, Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study, J. Orthop. Sci., 19, 933, 10.1007/s00776-014-0633-0
Nakamura, 2017, Denosumab significantly improves bone mineral density with or without bisphosphonate pre-treatment in osteoporosis with rheumatoid arthritis: Denosumab improves bone mineral density in osteoporosis with rheumatoid arthritis, Arch. Osteoporos., 12, 80, 10.1007/s11657-017-0371-y
Nakatsukasa, 2017, Effect of denosumab administration on low bone mineral density (T-score -1.0 to -2.5) in postmenopausal Japanese women receiving adjuvant aromatase inhibitors for non-metastatic breast cancer, J. Bone Miner. Metab., 10.1007/s00774-017-0884-x
Niziolek, 2015, Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia, PLoS One, 10, 10.1371/journal.pone.0140775
Novack, 2011, Role of NF-kappaB in the skeleton, Cell Res., 21, 169, 10.1038/cr.2010.159
Oh, 2008, Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells, Mol. Cell, 26, 486
Okamoto, 2014, Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis, Sci. Rep., 4, 4493, 10.1038/srep04493
Omori, 2015, Rosmarinic acid and arbutin suppress osteoclast differentiation by inhibiting superoxide and NFATc1 downregulation in RAW 264.7 cells, Biomed Rep, 3, 483, 10.3892/br.2015.452
Onodera, 2017, Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype, PLoS One, 12, 10.1371/journal.pone.0184702
Ornitz, 2005, FGF signaling in the developing endochondral skeleton, Cytokine Growth Factor Rev., 16, 205, 10.1016/j.cytogfr.2005.02.003
Ornitz, 2015, Fibroblast growth factor signaling in skeletal development and disease, Genes Dev., 29, 1463, 10.1101/gad.266551.115
Pan, 2013, A review of hedgehog signaling in cranial bone development, Front. Physiol., 4, 61, 10.3389/fphys.2013.00061
Panahi, 2014, Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial, Phytother. Res., 28, 1625, 10.1002/ptr.5174
Pandey, 2014, Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways, Exp. Hematol., 42, 883, 10.1016/j.exphem.2014.07.261
Pangrazio, 2012, RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations, J. Bone Miner. Res., 27, 342, 10.1002/jbmr.559
Park, 2010, FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization, J. Biol. Chem., 285, 3568, 10.1074/jbc.M109.055053
Park, 2014, Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment, Toxicol. Appl. Pharmacol., 275, 152, 10.1016/j.taap.2014.01.009
Pasquale, 2008, Eph-ephrin bidirectional signaling in physiology and disease, Cell, 133, 38, 10.1016/j.cell.2008.03.011
Pettit, 2006, RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis, Rheumatology (Oxford), 45, 1068, 10.1093/rheumatology/kel045
Phimphilai, 2006, BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype, J. Bone Miner. Res., 21, 637, 10.1359/jbmr.060109
Qiao, 1997, Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice, Am. J. Pathol., 150, 1687
Rachner, 2011, Osteoporosis: now and the future, Lancet, 377, 1276, 10.1016/S0140-6736(10)62349-5
Rahimnia, 2015, Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial, Drug Res (Stuttg), 65, 521
Rahman, 2015, TGF-beta/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation, Bone Res, 3, 15005, 10.1038/boneres.2015.5
Rantlha, 2017, Ellagic acid inhibits RANKL-induced osteoclast differentiation by suppressing the p38 MAP kinase pathway, Arch. Pharm. Res., 40, 79, 10.1007/s12272-016-0790-0
Regard, 2012, Wnt signaling in bone development and disease: making stronger bone with Wnts, Cold Spring Harb. Perspect. Biol., 4, 10.1101/cshperspect.a007997
Reginster, 2017, Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) confirms that abaloparatide is a valuable addition to the armamentarium against osteoporosis, Expert. Opin. Pharmacother., 18, 1811, 10.1080/14656566.2017.1395021
Ren, 2015, Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway, Genet. Mol. Res., 14, 15955, 10.4238/2015.December.7.7
Reuter, 2010, Embelin suppresses osteoclastogenesis induced by receptor activator of NF-kappaB ligand and tumor cells in vitro through inhibition of the NF-kappaB cell signaling pathway, Mol. Cancer Res., 8, 1425, 10.1158/1541-7786.MCR-10-0141
Reuter, 2012, Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug, Br. J. Pharmacol., 165, 2127, 10.1111/j.1476-5381.2011.01702.x
Riva, 2017, Health benefits of curcumin and curcumin phytosome in bone density disorders, JSM Bone Marrow Res, 1, 1006
Riva, 2017, Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study, Eur Rev Med Pharmacol Sci, 21, 1684
Roodman, 1999, Cell biology of the osteoclast, Exp. Hematol., 27, 1229, 10.1016/S0301-472X(99)00061-2
Roux, 2002, RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone, Am. J. Clin. Pathol., 117, 210, 10.1309/BPET-F2PE-P2BD-J3P3
Ruocco, 2005, I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss, J. Exp. Med., 201, 1677, 10.1084/jem.20042081
Ryoo, 1997, Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression, Mol. Endocrinol., 11, 1681, 10.1210/mend.11.11.0011
Sakai, 2012, Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis, J. Cell. Biochem., 113, 486, 10.1002/jcb.23372
Sakai, 2013, Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes, J. Pharmacol. Sci., 121, 288, 10.1254/jphs.12243FP
Sandur, 2007, Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products, Nutr. Cancer, 57, 78, 10.1080/01635580701268295
Sapir-Koren, 2017, Postmenopausal osteoporosis in rheumatoid arthritis: The estrogen deficiency-immune mechanisms link, Bone, 103, 102, 10.1016/j.bone.2017.06.020
Schett, 2011, Effects of inflammatory and anti-inflammatory cytokines on the bone, Eur. J. Clin. Investig., 41, 1361, 10.1111/j.1365-2362.2011.02545.x
Sethi, 2007, Mending the bones with natural products, Chem. Biol., 14, 738, 10.1016/j.chembiol.2007.07.002
Shakibaei, 2011, Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells, J. Biol. Chem., 286, 11492, 10.1074/jbc.M110.198713
Shang, 2016, Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways, Mol. Med. Rep., 14, 3620, 10.3892/mmr.2016.5674
Sharma, 2012, Clinical efficacy of 1% alendronate gel as a local drug delivery system in the treatment of chronic periodontitis: a randomized, controlled clinical trial, J. Periodontol., 83, 11, 10.1902/jop.2011.110091
Shen, 2009, Green tea and bone metabolism, Nutr. Res., 29, 437, 10.1016/j.nutres.2009.06.008
Shen, 2014, TGF-beta signaling and the development of osteoarthritis, Bone Res, 2, 10.1038/boneres.2014.2
Shimizu, 2017, Sequential treatment with zoledronic acid followed by teriparatide or vice versa increases bone mineral density and bone strength in ovariectomized rats, Bone reports, 7, 70, 10.1016/j.bonr.2017.06.001
Shin, 2012, Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model, Acta Biomater., 8, 3524, 10.1016/j.actbio.2012.05.002
Shin, 2017, Monthly Oral Ibandronate Reduces Bone Loss in Korean Women With Rheumatoid Arthritis and Osteopenia Receiving Long-term Glucocorticoids: A 48-week Double-blinded Randomized Placebo-controlled Investigator-initiated Trial, Clin. Ther., 39, 268, 10.1016/j.clinthera.2017.01.008
Shirley, 2017, Abaloparatide: First Global Approval, Drugs, 77, 1363, 10.1007/s40265-017-0780-7
Shishodia, 2006, Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression, Oncogene, 25, 1463, 10.1038/sj.onc.1209194
Shishodia, 2006
Shohrati, 2015, Effect of Nasal Calcitonin on the Health-Related Quality of Life in Postmenopause Women Affected With Low Bone Density, Iran Red Crescent Med J, 17
Singh, 1995, Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected], J. Biol. Chem., 270, 24995, 10.1074/jbc.270.42.24995
Song, 2012, Loss of wnt/beta-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes, J. Bone Miner. Res., 27, 2344, 10.1002/jbmr.1694
Southmayd, 2017, A summary of the influence of exogenous estrogen administration across the lifespan on the GH/IGF-1 axis and implications for bone health, 32, 2
Sreekumar, 2017, Resveratrol protects primary cilia integrity of human mesenchymal stem cells from cigarette smoke to improve osteogenic differentiation in vitro, Arch. Toxicol.
St-Jacques, 1999, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation, Genes Dev., 13, 2072, 10.1101/gad.13.16.2072
Streicher, 2017, Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells, Sci. Rep., 7, 6460, 10.1038/s41598-017-06614-0
Su, 2014, Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models, Bone Res, 2, 14003, 10.1038/boneres.2014.3
Sung, 2009, Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice, Cancer Res., 69, 1477, 10.1158/0008-5472.CAN-08-3249
Sung, 2011, Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling, Int. J. Cancer, 129, 2062, 10.1002/ijc.25868
Sung, 2012, Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling, Mol. Cancer Ther., 11, 350, 10.1158/1535-7163.MCT-11-0731
Sung, 2013, RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin, PLoS One, 8, 10.1371/journal.pone.0064118
Suzuki, 2018, Teriparatide Administration Increases Periprosthetic Bone Mineral Density After Total Knee Arthroplasty: A Prospective Study, J. Arthroplast., 33, 79, 10.1016/j.arth.2017.07.026
Takada, 2005, Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells, Blood, 106, 641, 10.1182/blood-2004-12-4589
Takada, 2006, Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression, J. Immunol., 176, 3127, 10.4049/jimmunol.176.5.3127
Takagi, 2017, Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP, Biochem. Biophys. Res. Commun., 483, 718, 10.1016/j.bbrc.2016.12.075
Takatsuka, 1998, Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor, J. Submicrosc. Cytol. Pathol., 30, 239
Takyar, 2013, EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone, J. Bone Miner. Res., 28, 912, 10.1002/jbmr.1820
Tao, 2016, Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt/beta-catenin signaling pathway, Toxicol. Lett., 240, 68, 10.1016/j.toxlet.2015.10.007
Teitelbaum, 2000, Bone resorption by osteoclasts, Science, 289, 1504, 10.1126/science.289.5484.1504
Tella, 2017, Profile of Abaloparatide and Its Potential in the Treatment of Postmenopausal Osteoporosis, Cureus, 9
TenBroek, 2016, Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat, Arthritis Res Ther, 18, 24, 10.1186/s13075-016-0921-5
Teven, 2014, Fibroblast growth factor (FGF) signaling in development and skeletal diseases, Genes Dis, 1, 199, 10.1016/j.gendis.2014.09.005
Thomas, 2006, Intermittent parathyroid hormone therapy to increase bone formation, Joint Bone Spine, 73, 262, 10.1016/j.jbspin.2005.11.007
Tolba, 2017, Caffeic acid phenethyl ester protects against glucocorticoid-induced osteoporosis in vivo: Impact on oxidative stress and RANKL/OPG signals, Toxicol. Appl. Pharmacol., 324, 26, 10.1016/j.taap.2017.03.021
Tou, 2015, Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy, Biochim. Biophys. Acta, 1852, 1186, 10.1016/j.bbadis.2014.10.003
Tsai, 2015, Syringetin suppresses osteoclastogenesis mediated by osteoblasts in human lung adenocarcinoma, Oncol. Rep., 34, 617, 10.3892/or.2015.4028
Tsuji, 2006, BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing, Nat. Genet., 38, 1424, 10.1038/ng1916
Tsuji, 2009, Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice, J. Bone Miner. Metab., 27, 673, 10.1007/s00774-009-0088-0
Tu, 2007, Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation, Dev. Cell, 12, 113, 10.1016/j.devcel.2006.11.003
Tyagi, 2016, Calebin A downregulates osteoclastogenesis through suppression of RANKL signalling, Arch. Biochem. Biophys., 593, 80, 10.1016/j.abb.2016.02.013
Udagawa, 1990, Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells, Proc. Natl. Acad. Sci. U. S. A., 87, 7260, 10.1073/pnas.87.18.7260
Umeda, 1996, Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation, J. Submicrosc. Cytol. Pathol., 28, 13
Usami, 2016, Wnt signaling in cartilage development and diseases: lessons from animal studies, Lab. Investig., 96, 186, 10.1038/labinvest.2015.142
Walsh, 2014, Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond, Front. Immunol., 5, 511, 10.3389/fimmu.2014.00511
Wang, 2014, Bone Morphogenetic Protein (BMP) signaling in development and human diseases, Genes Dis, 1, 87, 10.1016/j.gendis.2014.07.005
Wang, 2014, Quercetin reversed lipopolysaccharide-induced inhibition of osteoblast differentiation through the mitogenactivated protein kinase pathway in MC3T3-E1 cells, Mol. Med. Rep., 10, 3320, 10.3892/mmr.2014.2633
Wang, 2014, Wnt and the Wnt signaling pathway in bone development and disease, Front Biosci (Landmark Ed), 19, 379, 10.2741/4214
Wang, 2015, Andrographolide Inhibits Ovariectomy-Induced Bone Loss via the Suppression of RANKL Signaling Pathways, Int. J. Mol. Sci., 16, 27470, 10.3390/ijms161126039
Wang, 2016, Curcumin protects human adipose-derived mesenchymal stem cells against oxidative stress-induced inhibition of osteogenesis, J. Pharmacol. Sci., 132, 192, 10.1016/j.jphs.2016.10.005
Watanabe, 2016, Ibandronate concomitantly blocks immobilization-induced bone and muscle atrophy, Biochem. Biophys. Res. Commun., 480, 662, 10.1016/j.bbrc.2016.10.112
Wattel, 2004, Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1, J. Cell. Biochem., 92, 285, 10.1002/jcb.20071
Wei, 2005, IL-1 mediates TNF-induced osteoclastogenesis, J. Clin. Invest., 115, 282, 10.1172/JCI200523394
Wei, 2009, Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells, Zhong Xi Yi Jie He Xue Bao, 7, 342, 10.3736/jcim20090408
Wieland, 2004, Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome, Am. J. Hum. Genet., 74, 1209, 10.1086/421532
Wozney, 1992, The bone morphogenetic protein family and osteogenesis, Mol. Reprod. Dev., 32, 160, 10.1002/mrd.1080320212
Wu, 2012, J. Bone Miner. Res., 27, 1298, 10.1002/jbmr.1576
Wu, 2018, Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERbeta-SATB2 pathway, J. Cell. Physiol., 233, 4194, 10.1002/jcp.26233
Xin, 2015, Attenuation of hind-limb suspension-induced bone loss by curcumin is associated with reduced oxidative stress and increased vitamin D receptor expression, Osteoporos. Int., 26, 2665, 10.1007/s00198-015-3153-7
Xu, 2010, Preventive effects of berberine on glucocorticoid-induced osteoporosis in rats, Planta Med., 76, 1809, 10.1055/s-0030-1250040
Xu, 2016, Fructus Ligustri Lucidi ethanol extract inhibits osteoclastogenesis in RAW264.7 cells via the RANKL signaling pathway, Mol. Med. Rep., 14, 4767, 10.3892/mmr.2016.5849
Yamaguchi, 2011, Quercetin, a potent suppressor of NF-kappaB and Smad activation in osteoblasts, Int. J. Mol. Med., 28, 521
Yamaguchi, 2011, Honokiol stimulates osteoblastogenesis by suppressing NF-kappaB activation, Int. J. Mol. Med., 28, 1049
Yamaguchi, 2015, Curcumin analog UBS109 prevents bone marrow osteoblastogenesis and osteoclastogenesis disordered by coculture with breast cancer MDA-MB-231 bone metastatic cells in vitro, Mol. Cell. Biochem., 401, 1, 10.1007/s11010-014-2286-x
Yang, 2011, Classic yin and yang tonic formula for osteopenia: study protocol for a randomized controlled trial, Trials, 12, 187, 10.1186/1745-6215-12-187
Yang, 2014, Emodin enhances osteogenesis and inhibits adipogenesis, BMC Complement. Altern. Med., 14, 74, 10.1186/1472-6882-14-74
Yang, 2015, The Hedgehog signalling pathway in bone formation, Int J Oral Sci, 7, 73, 10.1038/ijos.2015.14
Yavropoulou, 2007, The role of the Wnt signaling pathway in osteoblast commitment and differentiation, Hormones (Athens), 6, 279, 10.14310/horm.2002.1111024
Ying, 2015, Silibinin alleviates high glucose-suppressed osteogenic differentiation of human bone marrow stromal cells via antioxidant effect and PI3K/Akt signaling, Eur. J. Pharmacol., 765, 394, 10.1016/j.ejphar.2015.09.005
Yu, 2015, 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice, J. Pharmacol. Sci., 127, 75, 10.1016/j.jphs.2014.11.006
Zainabadi, 2017, SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2, PLoS One, 12, 10.1371/journal.pone.0178520
Zawawi, 2015, Caffeic acid phenethyl ester abrogates bone resorption in a murine calvarial model of polyethylene particle-induced osteolysis, Calcif. Tissue Int., 96, 565, 10.1007/s00223-015-9982-8
Zhai, 2014, Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo, Br. J. Pharmacol., 171, 663, 10.1111/bph.12463
Zhang, 2013, Wnt/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts, Bone, 52, 145, 10.1016/j.bone.2012.09.029
Zhang, 2014, The roles of bone morphogenetic proteins and their signaling in the osteogenesis of adipose-derived stem cells, Tissue Eng Part B Rev, 20, 84, 10.1089/ten.teb.2013.0204
Zhang, 2015, Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways, Mol. Cell. Biochem., 407, 41, 10.1007/s11010-015-2452-9
Zhang, 2016, Genistein induces adipogenic differentiation in human bone marrow mesenchymal stem cells and suppresses their osteogenic potential by upregulating PPARgamma, Exp Ther Med, 11, 1853, 10.3892/etm.2016.3120
Zhao, 2006, Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis, Cell Metab., 4, 111, 10.1016/j.cmet.2006.05.012
Zhao, 2011, Quinoxaline derivative of oleanolic acid inhibits osteoclastic bone resorption and prevents ovariectomy-induced bone loss, Menopause, 18, 690, 10.1097/gme.0b013e3181fd7f4b
Zhao, 2014, Long-term resveratrol treatment prevents ovariectomy-induced osteopenia in rats without hyperplastic effects on the uterus, Br. J. Nutr., 111, 836, 10.1017/S0007114513003115
Zhao, 2015, Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative character, J. Nutr. Biochem., 26, 1174, 10.1016/j.jnutbio.2015.05.009
Zheng, 2017, Butein inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice, Int. Immunopharmacol., 42, 1, 10.1016/j.intimp.2016.11.009
Zhou, 2014, Osteogenic differentiation of adipose-derived stem cells promoted by quercetin, Cell Prolif., 47, 124, 10.1111/cpr.12097
Zhou, 2015, The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells, PLoS One, 10, 10.1371/journal.pone.0129605
Zou, 2016, Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro, Drug Des Devel Ther, 10, 933
Zwerina, 2007, TNF-induced structural joint damage is mediated by IL-1, Proc. Natl. Acad. Sci. U. S. A., 104, 11742, 10.1073/pnas.0610812104