Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women

Journal of Clinical Endocrinology and Metabolism - Tập 89 Số 6 - Trang 2963-2972 - 2004
Karen L. Teff1,2, Sharon S. Elliott3, Matthias H. Tschöp4, Timothy J. Kieffer5, Daniel J. Rader1, Mark L. Heiman4, Raymond R. Townsend1, Nancy L. Keim6, David D’Alessio7, Peter J. Havel3
1Department of Medicine (K.L.T., D.R., R.R.T.), University of Pennsylvania, Philadelphia, Pennsylvania 19104
2Monell Chemical Senses Center (K.L.T.), Philadelphia, Pennsylvania 19104
3Department of Nutrition, University of California, Davis (S.S.E., P.J.H.), Davis, California 95616
4Eli Lilly (M.T., M.H.), Indianapolis, Indiana 46285
5University of British Columbia (T.J.K.), Vancouver, British Columbia, Canada V6T 1Z4
6U.S. Department of Agriculture, Western Human Nutrition Research Center (N.L.K.), Davis, California 95616
7Department of Medicine, University of Cincinnati (D.D.), Cincinnati, Ohio 45267

Tóm tắt

Từ khóa


Tài liệu tham khảo

Havel, 1999, High-fat meals reduce 24-h circulating leptin concentrations in women., Diabetes, 48, 334, 10.2337/diabetes.48.2.334

Mueller, 1998, Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes., Endocrinology, 139, 551, 10.1210/endo.139.2.5716

Havel, 2002, Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin., Curr Opin Lipidol, 13, 51, 10.1097/00041433-200202000-00008

Porte Jr, 2002, Leptin and insulin action in the central nervous system, Nutr Rev, 60, S20, 10.1301/002966402320634797

Astrup, 2000, The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies., Int J Obes Relat Metab Disord, 24, 1545, 10.1038/sj.ijo.0801453

Havel, 1996, Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss., J Clin Endocrinol Metab, 81, 4406

Curry, 1989, Effects of mannose and fructose on the synthesis and secretion of insulin., Pancreas, 4, 2, 10.1097/00006676-198902000-00002

Havel, 1997, Glucose but not fructose infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys., Exp Clin Endocrinol Diabetes, 105, 37, 10.1055/s-0029-1211853

Farooqi, 2001, Partial leptin deficiency and human adiposity., Nature, 414, 34, 10.1038/35102112

Weigle, 2003, Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet., J Clin Endocrinol Metab, 88, 1577, 10.1210/jc.2002-021262

Putnam JJ, Allshouse JE 1999 Food consumption, prices and expenditures, 1970–1997. Washington, DC: U.S. Department of Agriculture, Economic Research Service

Kuczmarski, 1994, Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991., JAMA, 272, 205, 10.1001/jama.1994.03520030047027

Grundy, 1998, Multifactorial causation of obesity: implications for prevention, Am J Clin Nutr, 67, 563S, 10.1093/ajcn/67.3.563S

Wren, 2001, Ghrelin enhances appetite and increases food intake in humans., J Clin Endocrinol Metab, 86, 5992, 10.1210/jcem.86.12.8111

Cummings, 2001, A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans., Diabetes, 50, 1714, 10.2337/diabetes.50.8.1714

Beck, 2002, Ghrelin, macronutrient intake and dietary preferences in Long-Evans rats., Biochem Biophys Res Commun, 292, 1031, 10.1006/bbrc.2002.6737

Lee, 2002, Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations., Endocrinology, 143, 185, 10.1210/endo.143.1.8602

Kong, 1999, Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects., Peptides, 20, 545, 10.1016/S0196-9781(99)00006-6

Vozzo, 2002, Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes., Metabolism, 51, 949, 10.1053/meta.2002.34012

Elliott, 2002, Fructose, weight gain, and the insulin resistance syndrome., Am J Clin Nutr, 76, 911, 10.1093/ajcn/76.5.911

Stunkard, 1985, The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger., J Psychosom Res, 29, 71, 10.1016/0022-3999(85)90010-8

Mifflin, 1990, A new predictive equation for resting energy expenditure in healthy individuals., Am J Clin Nutr, 51, 241, 10.1093/ajcn/51.2.241

Lee, 1993, Tonic sympathetic nervous system inhibition of insulin secretion is diminished in obese Zucker rats., Obes Res, 1, 371, 10.1002/j.1550-8528.1993.tb00015.x

Cummings, 2002, Elevated plasma ghrelin levels in Prader Willi syndrome., Nat Med, 8, 643, 10.1038/nm0702-643

Cummings, 2002, Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery., N Engl J Med, 346, 1623, 10.1056/NEJMoa012908

Kuzio, 1974, Radioimmunoassay for gastric inhibitory polypeptide., Gastroenterology, 66, 357, 10.1016/S0016-5085(74)80134-4

Morgan, 1978, Radioimmunoassay of gastric inhibitory polypeptide., Ann Clin Biochem, 15, 172, 10.1177/000456327801500138

Sato, 1996, Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets., Tissue Cell, 28, 637, 10.1016/S0040-8166(96)80067-X

Bantle, 1983, Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects., N Engl J Med, 309, 7, 10.1056/NEJM198307073090102

Havel, 2000, Role of adipose tissue in body weight regulation: mechanisms regulating leptin production and energy balance., Proc Nutr Soc, 59, 359, 10.1017/S0029665100000410

McCowen, 2002, Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents, J Endocrinol, 175, R7, 10.1677/joe.0.175R007

Djurhuus, 2002, Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion., Horm Metab Res, 34, 411, 10.1055/s-2002-33475

Saad, 2002, Insulin regulates plasma ghrelin concentration., J Clin Endocrinol Metab, 87, 3997, 10.1210/jcem.87.8.8879

Flanagan, 2003, The influence of insulin on circulating ghrelin, Am J Physiol, 284, E313

Horvath, 2001, Minireview: ghrelin and the regulation of energy balance—a hypothalamic perspective., Endocrinology, 142, 4163, 10.1210/endo.142.10.8490

English, 2002, Food fails to suppress ghrelin levels in obese humans., J Clin Endocrinol Metab, 87, 2984, 10.1210/jcem.87.6.8738

DelParigi, 2002, High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome., J Clin Endocrinol Metab, 87, 5461, 10.1210/jc.2002-020871

Faraj, 2003, Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects., J Clin Endocrinol Metab, 88, 1594, 10.1210/jc.2002-021309

Moukarzel, 1996, Gastric physiology and function: effects of fruit juices, J Am Coll Nutr, 15, 18S, 10.1080/07315724.1996.10720470

Pederson, 1996, The enteroinsular axis in dipeptidyl peptidase IV-negative rats., Metabolism, 45, 1335, 10.1016/S0026-0495(96)90112-2

Vahl, 2003, Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism., Curr Opin Clin Nutr Metab Care, 6, 461, 10.1097/01.mco.0000078991.96795.84

Drucker, 2002, Biological actions and therapeutic potential of the glucagon-like peptides., Gastroenterology, 122, 531, 10.1053/gast.2002.31068

Mayes, 1993, Intermediary metabolism of fructose, Am J Clin Nutr, 58, 754S, 10.1093/ajcn/58.5.754S

Grant, 1994, Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance., Am J Clin Nutr, 59, 853, 10.1093/ajcn/59.4.853

Jeppesen, 1995, Postprandial triglyceride and retinyl ester responses to oral fat: effects of fructose., Am J Clin Nutr, 61, 787, 10.1093/ajcn/61.4.787

Bantle, 2000, Effects of dietary fructose on plasma lipids in healthy subjects., Am J Clin Nutr, 72, 1128, 10.1093/ajcn/72.5.1128

Raben, 2001, Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women., Am J Clin Nutr, 73, 177, 10.1093/ajcn/73.2.177

Hollenbeck, 1993, Dietary fructose effects on lipoprotein metabolism and risk for coronary artery disease, Am J Clin Nutr, 58, 800S, 10.1093/ajcn/58.5.800S

Havel, 2003, Short-term and long-term consumption of high fructose, but not high glucose diets, increases postprandial triglycerides and apo-lipoprotein-B in women, J Invest Med, 51, S163

Abraha, 1998, Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects., Br J Nutr, 80, 169, 10.1017/S000711459800107X

Park, 1993, Intakes and food sources of fructose in the United states, Am J Clin Nutr, 58, 727S

Havel, 2001, Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis., Exp Biol Med, 226, 963, 10.1177/153537020122601102

Tordoff, 1990, Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight., Am J Clin Nutr, 51, 963, 10.1093/ajcn/51.6.963

Anderson, 1989, Metabolic effects of fructose supplementation in diabetic individuals., Diabetes Care, 12, 337, 10.2337/diacare.12.5.337

Schwarz, 1993, De novo lipogenesis during fasting and oral fructose ingestion in lean and obese hyperinsulinemic subjects, Diabetes, 42, A39

Hellerstein, 1996, Regulation of hepatic de novo lipogenesis in humans., Annu Rev Nutr, 16, 523, 10.1146/annurev.nu.16.070196.002515

Harnack, 1999, Soft drink consumption among US children and adolescents: nutritional consequences., J Am Diet Assoc, 99, 436, 10.1016/S0002-8223(99)00106-6

Ludwig, 2001, Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis., Lancet, 357, 505, 10.1016/S0140-6736(00)04041-1

Lluch, 2000, Dietary intakes, eating style and overweight in the Stanislas Family Study., Int J Obes Relat Metab Disord, 24, 1493, 10.1038/sj.ijo.0801425

Laessle, 2000, Restrained eating and leptin levels in overweight preadolescent girls., Physiol Behav, 70, 45, 10.1016/S0031-9384(00)00243-2

Hood, 2000, Parental eating attitudes and the development of obesity in children. The Framingham Children’s Study., Int J Obes Relat Metab Disord, 24, 1319, 10.1038/sj.ijo.0801396

Carper, 2000, Young girls’ emerging dietary restraint and disinhibition are related to parental control in child feeding., Appetite, 5, 121, 10.1006/appe.2000.0343

Tuschl, 1990, Differences in food-choice frequencies between restrained and unrestrained eaters., Appetite, 14, 9, 10.1016/0195-6663(90)90050-I

Rogers, 1999, Eating habits and appetite control: a psychobiological perspective., Proc Nutr Soc, 58, 59, 10.1079/PNS19990009

Greeno, 1994, Stress-induced eating., Psychol Bull, 115, 444, 10.1037/0033-2909.115.3.444

Rodin, 1988, Metabolic effects of fructose and glucose: implications for food intake., Am J Clin Nutr, 47, 683, 10.1093/ajcn/47.4.683

Rodin, 1991, Effects of pure sugar vs. mixed starch fructose loads on food intake., Appetite, 17, 213, 10.1016/0195-6663(91)90023-L

Havel, 2004, Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism, Diabetes, 53, S143, 10.2337/diabetes.53.2007.S143