Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association

Ovid Technologies (Wolters Kluwer Health) - Tập 135 Số 17 - 2017
Brian W. McCrindle, Anne H. Rowley, Jane W. Newburger, Jane C. Burns, Anne F. Bolger, Michael H. Gewitz, Annette Baker, Mary Anne Jackson, Masato Takahashi, Pinak B. Shah, Tohru Kobayashi, Mei‐Hwan Wu, Tsutomu Saji, Elfriede Pahl

Tóm tắt

Background: Kawasaki disease is an acute vasculitis of childhood that leads to coronary artery aneurysms in ≈25% of untreated cases. It has been reported worldwide and is the leading cause of acquired heart disease in children in developed countries. Methods and Results: To revise the previous American Heart Association guidelines, a multidisciplinary writing group of experts was convened to review and appraise available evidence and practice-based opinion, as well as to provide updated recommendations for diagnosis, treatment of the acute illness, and long-term management. Although the cause remains unknown, discussion sections highlight new insights into the epidemiology, genetics, pathogenesis, pathology, natural history, and long-term outcomes. Prompt diagnosis is essential, and an updated algorithm defines supplemental information to be used to assist the diagnosis when classic clinical criteria are incomplete. Although intravenous immune globulin is the mainstay of initial treatment, the role for additional primary therapy in selected patients is discussed. Approximately 10% to 20% of patients do not respond to initial intravenous immune globulin, and recommendations for additional therapies are provided. Careful initial management of evolving coronary artery abnormalities is essential, necessitating an increased frequency of assessments and escalation of thromboprophylaxis. Risk stratification for long-term management is based primarily on maximal coronary artery luminal dimensions, normalized as Z scores, and is calibrated to both past and current involvement. Patients with aneurysms require life-long and uninterrupted cardiology follow-up. Conclusions: These recommendations provide updated and best evidence-based guidance to healthcare providers who diagnose and manage Kawasaki disease, but clinical decision making should be individualized to specific patient circumstances.

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Tài liệu tham khảo

10.1161/01.CIR.0000145143.19711.78

10.1161/01.CIR.0000063682.20730.A5

10.1161/01.CIR.0000079017.53579.9C

10.1097/INF.0b013e318166d795

10.1542/peds.106.2.e27

Gee, SJ. Cases of morbid anatomy: aneurysms of coronary arteries in a boy. St Bartholomews Hosp Rep. 1871;7:141–148.

10.1542/peds.59.5.651

10.1001/archpedi.1995.02170200069011

10.1017/S1047951111001818

10.1111/j.1468-3083.2012.04488.x

10.1007/s11926-010-0159-1

10.1097/INF.0b013e31820e3849

10.2188/jea.JE20100144

10.1016/j.jpeds.2012.12.011

10.1136/adc.2010.194001

10.2188/jea.JE20110131

10.1111/j.1442-200X.2012.03692.x

Holman, RC, Christensen, KY, Belay, ED, Steiner, CA, Effler, PV, Miyamura, J, Forbes, S, Schonberger, LB, Melish, M. Racial/ethnic differences in the incidence of Kawasaki syndrome among children in Hawaii. Hawaii Med J. 2010;69:194–197.

10.1542/peds.111.5.1124

10.1542/peds.112.3.495

10.1097/INF.0b013e3181cf8705

10.1542/peds.102.6.e65

10.1111/j.1651-2227.1994.tb12986.x

10.1111/j.1651-2227.2001.tb00253.x

10.1111/ped.12733

10.1111/j.1442-200X.2012.03628.x

10.1542/peds.102.6.e66

10.1542/peds.84.4.666

Harada, F, Sada, M, Kamiya, T, Yanase, Y, Kawasaki, T, Sasazuki, T. Genetic analysis of Kawasaki syndrome. Am J Hum Genet. 1986;39:537–539.

10.1097/INF.0b013e31822ac4ff

10.1203/00006450-200105000-00013

10.1542/peds.95.4.475

10.1111/j.1651-2227.1999.tb00048.x

10.1203/00006450-200301000-00026

10.1111/j.1651-2227.2003.tb00602.x

10.1161/01.CIR.97.4.410

10.1371/journal.pone.0074529

10.1016/S0140-6736(82)90660-2

10.1056/NEJM198106253042603

10.1097/00006454-200011000-00012

10.1001/archpedi.1995.02170130068016

10.1097/00006454-198711000-00002

10.1542/peds.87.5.663

10.1097/00006454-200210000-00018

10.1097/00006454-198807120-00006

10.1016/S0022-3476(05)80026-5

10.1097/INF.0b013e31825eaed0

10.1038/srep00152

10.1073/pnas.1400380111

10.2188/jea.JE20140089

10.1253/circj.72.134

10.2188/jea.JE20130048

10.1542/peds.109.6.e87

10.1542/peds.61.1.100

10.1016/S0022-3476(84)80114-6

10.1016/0735-1097(96)00099-X

10.1161/CIRCULATIONAHA.111.082107

10.1001/archpedi.159.9.876

10.1253/circj.CJ-12-0568

10.1001/archpedi.158.12.1166

10.1136/jmg.2010.086611

10.1093/hmg/ddq176

10.1038/ng.2220

10.1038/ng.2007.59

10.1161/CIRCGENETICS.110.940858

10.3109/08916930903405891

10.1371/journal.pone.0001582

10.1093/infdis/jiq136

10.1111/j.1365-2249.2005.02821.x

10.3109/08916934.2013.860524

Amano, S, Hazama, F, Kubagawa, H, Tasaka, K, Haebara, H, Hamashima, Y. General pathology of Kawasaki disease: on the morphological alterations corresponding to the clinical manifestations. Acta Pathol Jpn. 1980;30:681–694.

10.1086/497171

10.1371/journal.pone.0038998

10.1253/jcj.43.633

Naoe, S, Takahashi, K, Masuda, H, Tanaka, N. Kawasaki disease: with particular emphasis on arterial lesions. Acta Pathol Jpn. 1991;41:785–797.

Landing, BH, Larson, EJ. Pathological features of Kawasaki disease (mucocutaneous lymph node syndrome). Am J Cardiovasc Pathol. 1987;1:218–229.

10.1016/S0022-3476(82)80639-2

10.1253/circj.CJ-11-0928

10.1161/01.CIR.103.2.335

10.1067/mpd.2000.107840

Smith, LB, Newburger, JW, Burns, JC. Kawasaki syndrome and the eye. Pediatr Infect Dis J. 1989;8:116–118.

10.1097/00006454-198505000-00010

10.1016/0002-9394(82)90465-2

10.1016/j.jpeds.2012.11.064

10.1097/RCT.0b013e31823b4497

10.3345/kjp.2012.55.12.470

10.1542/peds.2005-0559

10.1542/peds.2015-0950

10.1093/cid/cis807

10.1016/j.jpeds.2015.11.021

10.1093/cid/cis811

10.1542/peds.2007-0815

10.1542/peds.2009-0606

10.1016/j.jpeds.2009.04.058

10.1161/CIRCIMAGING.112.000159

10.1097/INF.0b013e31826252b3

10.1177/0009922811409027

10.1097/00006454-199806000-00008

Poon, LK, Lun, KS, Ng, YM. Facial nerve palsy and Kawasaki disease. Hong Kong Med J. 2000;6:224–226.

10.1053/ajot.2001.26495

10.1016/S0104-4230(11)70062-8

10.1016/j.jpeds.2006.01.039

10.1016/j.jpeds.2008.10.006

10.1097/INF.0b013e3181cacede

10.1097/MPH.0b013e3181dccbf4

10.1097/INF.0b013e31822d4f56

10.1097/INF.0b013e3181f6fe2a

10.1097/INF.0b013e318193ec8e

10.1007/s00246-009-9441-2

10.1136/bmjopen-2014-006703

10.1016/j.jacc.2010.08.619

10.1253/circj.72.274

10.1016/S0828-282X(08)70683-4

10.1007/s00246-014-0926-2

Haney, I, Beghetti, M, McCrindle, BW, Gow, RM. Ventricular arrhythmia complicating Kawasaki disease. Can J Cardiol. 1995;11:931–933.

10.1253/circj.69.870

10.1007/s00134-012-2473-8

10.1542/peds.2008-1871

10.1542/peds.2008-1275

Yutani, C, Go, S, Kamiya, T, Hirose, O, Misawa, H, Maeda, H, Kozuka, T, Onishi, S. Cardiac biopsy of Kawasaki disease. Arch Pathol Lab Med. 1981;105:470–473.

10.1097/00006231-199307000-00004

10.1111/j.1365-2559.2012.04332.x

10.1016/0002-8703(90)90081-8

10.1016/0002-9149(88)90950-2

10.1016/S0002-9149(00)01541-1

10.1056/NEJM198608073150601

10.1056/NEJM199106063242305

10.1097/INF.0b013e318266bcf9

10.1016/j.ijcard.2008.04.019

10.1016/j.echo.2012.05.019

10.1016/j.jpeds.2015.04.036

10.1093/clinids/14.1.121

10.1016/j.jaad.2010.04.029

10.1016/S0735-1097(86)80505-8

10.1016/j.echo.2010.10.015

10.1111/j.1442-200X.2010.03252.x

10.1253/circj.CJ-10-74-0903

10.1016/S0022-3476(98)70229-X

10.1161/CIRCULATIONAHA.107.690875

10.1007/s00246-009-9599-7

10.1016/j.ijcard.2013.06.027

10.1046/j.1442-200X.2002.01508.x

10.1007/s00246-002-0300-7

10.1016/j.echo.2008.11.003

10.1016/j.echo.2016.03.017

10.1016/j.echo.2010.10.004

Du Bois, D, Du Bois, EF. A formula to estimate the approximate surface area if height and weight be known: 1916. Nutrition. 1989;5:303–311.

10.1016/S0022-3476(78)80601-5

10.1056/NEJM198710223171717

10.1016/j.echo.2015.08.013

10.1542/peds.2004-2190

10.1002/ccd.21892

10.1161/CIRCIMAGING.112.976969

10.1007/s00247-011-2141-0

10.1007/s00247-006-0281-4

10.1111/j.1540-8175.2011.01486.x

10.1007/s10165-004-0324-3

10.1016/S0022-3476(97)70038-6

10.1016/S0140-6736(84)91504-6

Oates-Whitehead, RM, Baumer, JH, Haines, L, Love, S, Maconochie, IK, Gupta, A, Roman, K, Dua, JS, Flynn, I. Intravenous immunoglobulin for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev. 2003;(4):CD004000.

10.1586/1744666X.2015.1044980

10.1542/peds.96.6.1057

10.1111/j.1442-200X.1998.tb01915.x

10.1016/S0022-3476(95)70233-4

Centers for Disease Control and Prevention (CDC). Outbreak of hepatitis C associated with intravenous immunoglobulin administration: United States, October 1993-June 1994. MMWR Morb Mortal Wkly Rep. 1994;43:505–509.

10.1586/1744666X.2015.1079485

10.1111/trf.13089

10.1111/trf.13090

10.1016/j.cyto.2012.08.006

10.1186/1546-0096-9-28

10.1097/00006454-199812000-00009

10.1016/j.jpeds.2005.08.024

Silverman, ED, Huang, C, Rose, V, Boutin, C, Smallhorn, J, McCrindle, BW, Laxer, RM. IVGG treatment of Kawasaki disease: are all brands equal? Kato, H, ed. In: Kawasaki Disease: Proceedings of the 5th International Kawasaki Disease Symposium, Fukuoka, Japan, 22–25 May 1995. New York, NY: Elsevier; 1995:301–304.

Kawasaki disease. In: Red Book. 2015 Report of the Committee on Infectious Diseases. Elk Grove, IL: American Academy of Pediatrics; 2015:494–500.

10.1161/01.CIR.89.2.916

10.1056/NEJMoa061235

Baumer, JH, Love, SJ, Gupta, A, Haines, LC, Maconochie, I, Dua, JS. Salicylate for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev. 2006;(4):CD004175.

10.1056/NEJMoa003199

Lee, JH, Hung, HY, Huang, FY. Kawasaki disease with Reye syndrome: report of one case. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1992;33:67–71.

10.1542/peds.77.4.616

Takahashi, M, Mason, W, Thomas, D, Sinatra, F. Reye syndrome following Kawasaki syndrome confirmed by liver histopathology. Kato, H, ed. In: Kawasaki Disease: Proceedings of the 5th International Kawasaki Disease Symposium, Fukuoka, Japan, 22–25 May 1995. New York, NY: Elsevier; 1995:436–444.

10.1067/mpd.2003.258

10.1253/jcj.46.1239

10.1016/S0022-3476(99)70169-1

10.1016/j.jpeds.2006.05.025

10.1007/s00431-008-0727-9

10.1016/j.jpeds.2006.03.050

10.1542/peds.2011-0148

10.1161/CIRCULATIONAHA.105.592865

10.1016/S0140-6736(11)61930-2

10.1136/heartjnl-2012-302126

10.1016/j.jpeds.2010.10.031

10.1016/0090-1229(90)90166-N

Weiss, JE, Eberhard, BA, Chowdhury, D, Gottlieb, BS. Infliximab as a novel therapy for refractory Kawasaki disease. J Rheumatol. 2004;31:808–810.

10.1016/j.jpeds.2008.06.011

10.1203/PDR.0b013e31819ed68d

10.1016/S0140-6736(13)62298-9

10.1016/j.jpeds.2010.06.014

10.1016/j.ahj.2010.12.003

10.1016/j.jpeds.2007.12.021

10.1093/jpids/piw075

10.1038/gene.2014.47

10.1016/j.jaci.2011.04.027

10.2188/jea.JE2008001

10.1542/peds.2008-0730

10.1007/s00246-002-0216-2

10.1097/INF.0b013e31815922b5

10.1097/INF.0b013e3181f386db

10.1007/s00431-006-0223-z

10.1097/INF.0b013e31828e887f

10.1016/S0022-3476(05)80972-2

10.1016/j.jpeds.2013.01.022

10.1016/j.jpeds.2010.10.012

10.1016/j.jpeds.2004.12.022

10.1097/INF.0b013e318220c3cf

10.1016/j.jpeds.2012.02.048

10.1186/1546-0096-12-26

10.1136/annrheumdis-2012-201658

10.1542/peds.105.6.e78

10.1111/j.1442-200X.2011.03487.x

10.1016/S0022-3476(96)70447-X

10.1067/mpd.2000.108444

Lang, BA, Yeung, RS, Oen, KG, Malleson, PN, Huber, AM, Riley, M, Ebbeson, R, Ramsey, SE, Laxer, RM, Silverman, ED, McCrindle, BW, Ratnapalan, S, Feldman, BM. Corticosteroid treatment of refractory Kawasaki disease. J Rheumatol. 2006;33:803–809.

10.1093/pch/16.8.479

Han, RK, Sinclair, B, Newman, A, Silverman, ED, Taylor, GW, Walsh, P, McCrindle, BW. Recognition and management of Kawasaki disease. CMAJ. 2000;162:807–812.

10.1136/adc.2007.126144

10.1016/j.jjcc.2008.08.002

10.1007/s00246-012-0589-9

10.3899/jrheum.110877

10.1086/323155

10.1038/ng.981

10.1161/CIRCGENETICS.116.001533

10.1007/s00431-003-1267-y

10.1111/j.1442-200X.1989.tb01384.x

10.1161/01.CIR.79.6.1237

Moran, AM, Newburger, JW, Sanders, SP, Parness, IA, Spevak, PJ, Burns, JC, Colan, SD. Abnormal myocardial mechanics in Kawasaki disease: rapid response to gamma-globulin. Am Heart J. 2000;139(pt 1):217–223.

10.1017/S1047951111001314

10.1097/PEC.0b013e3181fb0dc0

10.1097/CCM.0b013e31817d7ee4

10.1007/s00431-011-1426-5

10.1053/euhj.2000.2474

10.1161/hs1201.100829

10.1067/mhj.2003.180

10.1161/01.CIR.0000091201.39590.CB

10.1007/s00246-007-9132-9

10.1161/01.cir.0000436140.77832.7a

10.1161/CIR.0b013e3182742cf6

10.1056/NEJM200203283461302

10.1093/eurheartj/ehs215

10.1378/chest.11-2308

10.1067/mpd.2001.118428

10.1542/peds.109.1.e4

10.1016/j.amjcard.2010.01.332

10.1161/01.cir.0000053955.01455.5a

10.2165/00003495-200363110-00014

10.1517/14740338.2.1.49

10.1111/j.1365-2249.2011.04331.x

10.1016/j.ppedcard.2004.08.007

10.1016/S0022-3476(75)80220-4

10.1007/BF02315475

10.1001/archpedi.160.7.686

10.1177/0009922814566932

10.1161/01.CIR.94.6.1379

10.1016/S0022-3476(05)81894-3

10.1161/01.CIR.98.1.92

10.1007/s00246-012-0543-x

10.1111/j.1442-200X.2011.03403.x

10.1136/hrt.2003.025338

10.1016/0735-1097(93)90731-F

10.1097/MBC.0b013e32833d6ec2

10.1007/BF02279876

10.1007/s00246-010-9838-y

10.1161/01.CIR.89.1.258

10.1136/heart.83.3.307

10.1161/CIRCULATIONAHA.108.818609

10.1016/j.cjca.2014.04.028

10.1016/0735-1097(95)00447-5

10.1136/heart.87.6.559

10.1161/01.cir.0000018652.59840.57

10.1016/0735-1097(96)00199-4

10.1016/j.ijcard.2014.10.057

10.1161/01.CIR.94.9.2103

10.1371/journal.pone.0130913

10.1161/01.CIR.0000151311.38708.29

10.1136/hrt.2003.018507

10.1016/j.ijcard.2014.11.205

10.1016/S0735-1097(86)80354-0

10.1016/S0022-5223(96)70352-5

10.1046/j.1442-200X.2003.01666.x

10.1007/s002460010203

10.1016/j.echo.2012.03.003

10.1016/j.echo.2013.08.022

10.1007/s004310051321

10.1136/hrt.43.5.589

10.1253/jcj.56.352

10.1111/j.1442-200X.1993.tb03056.x

10.1017/S1047951109991132

10.1007/s00246-010-9694-9

10.1253/circj.71.357

10.1007/BF02505207

10.1017/S1047951105001344

10.1007/s00296-009-1252-5

10.1007/s00246-011-9908-9

10.1542/peds.2009-2107C

10.1111/j.1747-0803.2012.00670.x

10.1542/peds.104.5.e57

Lee, MH, Dai, ZK, Lee, MS, Hsu, JH, Chuang, HY, Wu, JR. The recommended frequency of echocardiography in follow-up evaluation of patients with Kawasaki disease. Acta Paediatr Taiwan. 2005;46:346–351.

10.1016/S0002-9149(01)01655-1

10.1161/CIRCULATIONAHA.107.749515

10.1161/CIRCULATIONAHA.109.874800

10.1016/j.pedneo.2012.12.013

10.1016/j.jacc.2009.06.057

10.1542/peds.2013-1638

10.1111/j.1442-200x.2004.01943.x

10.1016/j.jacc.2009.04.102

10.1161/01.CIR.96.10.3384

10.1111/j.1440-1754.2009.01531.x

10.1161/01.CIR.98.10.990

10.1097/MNM.0b013e3283411c67

10.1007/s00246-003-0472-9

10.1161/01.CIR.91.1.122

10.1007/s00246-002-0327-9

10.1016/0735-1097(95)00570-6

10.1016/j.jacc.2013.09.021

10.1016/j.jcmg.2014.05.017

10.1161/CIRCIMAGING.111.965996

10.1016/j.jacc.2003.10.032

10.4244/EIJV7I8A149

10.1161/CIRCIMAGING.113.001764

10.1111/chd.12131

10.1016/j.clinimag.2008.09.008

10.1007/s10554-013-0276-9

10.1016/j.jcmg.2011.12.010

10.1016/j.ijcard.2011.10.078

10.1097/MOP.0b013e32833e12f7

10.1161/CIRCULATIONAHA.106.179568

10.1253/jcj.46.1039

10.1161/01.CIR.84.2.625

10.1016/S0022-3476(05)82404-7

10.1111/j.1442-200X.1995.tb03402.x

10.1203/00006450-199711000-00017

10.1016/j.jacc.2003.08.030

10.1016/S0929-6646(09)60395-8

10.1016/j.jpeds.2014.06.017

10.1016/j.jpeds.2007.03.056

10.1016/j.jpeds.2007.03.057

10.1542/peds.107.5.1095

10.1016/j.jpeds.2009.04.054

10.1067/mpd.2001.111430

10.1111/1756-185X.12296

10.1177/0009922812441664

10.1161/CIRCULATIONAHA.106.183095

10.1161/CIR.0b013e318277d6a0

10.1161/01.cir.0000437738.63853.7a

10.1016/S0735-1097(02)02593-7

10.1001/jama.292.3.331

10.1253/circj.CJ-08-0121

10.1016/j.jjcc.2010.06.006

10.1007/s12519-014-0498-5

10.1007/s00246-013-0746-9

10.1046/j.1442-200x.2000.01270.x

10.1111/j.1442-200X.2007.02312.x

10.1007/s10237-011-0361-8

10.1007/s10237-014-0570-z

10.1097/01.mbc.0000046185.72384.65

10.1253/circj.CJ-08-0931

10.1007/s00246-010-9715-8

10.1007/BF02524798

10.1016/0735-1097(95)00003-M

10.1016/S0022-3476(05)81192-8

10.1177/1741826711420000

10.1161/CIR.0000000000000244

10.1016/j.ahj.2009.02.014

10.1161/CIR.0b013e318293688f

10.1161/01.CIR.0000151788.08740.5C

10.1161/CIRCULATIONAHA.106.180945

Stone, JA, Arthur, HM, Canadian Association of Cardiac Rehabilitation Guidelines Writing Group. Canadian guidelines for cardiac rehabilitation and cardiovascular disease prevention, second edition, 2004: executive summary. Can J Cardiol. 2005;21(suppl D):3D–19D.

10.1136/archdischild-2013-303826

10.1161/01.CIR.103.21.2591

10.1161/CIRCULATIONAHA.108.190690

10.1253/jcj.61.197

10.1111/1471-0528.12685

10.1017/S1047951106000126

10.1111/ped.12679

Ichinose, E, Kato, H, Inoue, O, Hirata, K, Eto, Y, Yoshioka, F. Intracoronary thrombolytic therapy in Kawasaki disease and the usefulness of two-dimensional echocardiography in detecting intracoronary thrombi [in Japanese]. J Cardiogr. 1985;15:79–87.

10.1007/BF00794192

10.1016/j.jcin.2015.12.011

10.1161/CIR.0b013e31823ba622

10.1056/NEJMoa070829

10.1161/CIRCULATIONAHA.107.743963

10.1056/NEJMoa1205361

10.1056/NEJMoa1211585

10.1161/01.CIR.0000138194.61225.10

10.1067/mpd.2000.107164

10.1161/01.cir.0000019733.56553.d8

10.1542/peds.100.4.695

10.1007/s00246-012-0409-2

10.1161/CIRCULATIONAHA.110.978213

10.1016/S0003-4975(00)01172-3

10.1001/archpedi.154.5.463

10.1007/s00296-009-1078-1

10.1542/peds.111.3.579

10.1016/j.jpeds.2009.09.041

10.1186/1471-2431-5-14

10.1016/j.jpeds.2012.01.071

10.1016/j.pedhc.2009.07.002

Ishikawa, S, Inaba, Y, Okuyama, K, Asakura, T, Kim, YS, Sasa, S. A study of psycho-social effects of chronic MCLS upon mothers. Prog Clin Biol Res. 1987;250:531–533.

10.1038/nrcardio.2013.172

10.1161/CIR.0b013e3182107c56

10.1093/jpepsy/jsp128

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