Developments in strategies for Quorum Sensing virulence factor inhibition to combat bacterial drug resistance

Miller, 2001, Quorum sensing in bacteria, Annu. Rev. Microbiol. [Internet], 55, 165, 10.1146/annurev.micro.55.1.165

Antunes, 2010, Quorum sensing in bacterial virulence, Microbiology, 156, 2271, 10.1099/mic.0.038794-0

Rasmussen, 2006, Quorum-sensing inhibitors as anti-pathogenic drugs, Int. J. Med. Microbiol., 296, 149, 10.1016/j.ijmm.2006.02.005

Kalia, 2013, Quorum sensing inhibitors: an overview, Biotechnol. Adv., 31, 224, 10.1016/j.biotechadv.2012.10.004

Rutherford, 2012, Bacterial quorum sensing: its role in virulence and possibilities for its control, Cold Spring Harb. Perspect. Med, 2, 10.1101/cshperspect.a012427

Novick, 2008, Quorum sensing in staphylococci, Annu. Rev. Genet. [Internet], 42, 541, 10.1146/annurev.genet.42.110807.091640

Gohar, 2008, The PlcR virulence regulon of Bacillus cereus, PLoS One, 3, 10.1371/journal.pone.0002793

Rai, 2012, Prediction by promoter logic in bacterial quorum sensing, PLoS Comput. Biol., 8, 10.1371/journal.pcbi.1002361

Wilder, 2011, Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems, ISME J., 5, 1332, 10.1038/ismej.2011.13

Choi, 2012, LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes, PLoS One, 7, 10.1371/journal.pone.0037059

Clarke, 2006, The QseC sensor kinase: a bacterial adrenergic receptor, Proc. Natl. Acad. Sci. India, 103, 10420

Reading, 2009, The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis, Proc. Natl. Acad. Sci. India, 106, 5889

Walters, 2006, Quorum sensing in Escherichia coli and Salmonella, Int J Med Microbiol., 296, 125, 10.1016/j.ijmm.2006.01.041

Gode-Potratz, 2011, Quorum sensing and silencing in Vibrio parahaemolyticus, J. Bacteriol., 193, 4224, 10.1128/JB.00432-11

Whitehead, 2001, Silencing the majority, Nat. Biotechnol. [Internet], 19, 735, 10.1038/90780

Hong, 2012, Quorum quenching revisited-from signal decays to signalling confusion, Sensors, 12, 4661, 10.3390/s120404661

Liu, 2010, Inhibitors of the pseudomonas aeruginosa quorum-sensing regulator, QscR, Biotechnol. Bioeng., 106, 119, 10.1002/bit.22672

Xu, 2003, Direct observation of substrate induction of resistance mechanism in Pseudomonas aeruginosa using single live cell imaging, Biochem. Biophys. Res. Commun., 305, 941, 10.1016/S0006-291X(03)00874-X

Liu, 2008, Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing, Proc. Natl. Acad. Sci. India, 105, 9769

Smith, 2003, Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer, Chem. Biol., 10, 563, 10.1016/S1074-5521(03)00107-8

Smith, 2003, Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs, Chem. Biol., 10, 81, 10.1016/S1074-5521(03)00002-4

Ikeda, 2001, The synthesis of optically pure enantiomers of N-Acyl-homoserine lactone autoinducers and their analogues, Chem. Lett., 314, 10.1246/cl.2001.314

Kim, 2009, Structural understanding of quorum-sensing inhibitors by molecular modeling study in Pseudomonas aeruginosa, Appl. Microbiol. Biotechnol., 83, 1095, 10.1007/s00253-009-1954-3

Morohoshi, 2007, Inhibition of quorum sensing in Serratia marcescens AS-1 by synthetic analogs of N-acylhomoserine lactone, Appl. Environ. Microbiol., 73, 6339, 10.1128/AEM.00593-07

Swift, 1999, Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila, Infect. Immun., 67, 5192, 10.1128/IAI.67.10.5192-5199.1999

Kumar, 2015, Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa, Fitoterapia, 102, 84, 10.1016/j.fitote.2015.02.002

Manefield, 2002, Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover, Microbiology, 148, 1119, 10.1099/00221287-148-4-1119

Givskov, 1996, Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling, J. Bacteriol., 178, 6618, 10.1128/jb.178.22.6618-6622.1996

Quintana, 2015, Marine organisms as source of extracts to disrupt bacterial communication: bioguided isolation and identification of quorum sensing inhibitors from Ircinia felix, Brazilian J. Pharmacogn., 25, 199, 10.1016/j.bjp.2015.03.013

Gram, 1996, Inhibitory effects of secondary metabolites from red algae Delisea pulchra on swarming motility of Proteus mirabilis, Appl. Environ. Microbiol., 62, 4284, 10.1128/AEM.62.11.4284-4287.1996

Schuster, 2003, Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis, J. Bacteriol., 185, 2066, 10.1128/JB.185.7.2066-2079.2003

Hjelmgaard, 2003, Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity, Bioorg. Med. Chem., 11, 3261, 10.1016/S0968-0896(03)00295-5

Lönn-Stensrud, 2009, Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?, J. Antimicrob. Chemother., 63, 309, 10.1093/jac/dkn501

Wu, 2004, Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice, J. Antimicrob. Chemother., 53, 1054, 10.1093/jac/dkh223

Martinelli, 2004, Effects of natural and chemically synthesized furanones on quorum sensing in Chromobacterium violaceum, BMC Microbiol., 4, 10.1186/1471-2180-4-25

Lowery, 2009, Revisiting AI-2 quorum sensing inhibitors: direct comparison of alkyl-DPD analogues and a natural product fimbrolide, J. Am. Chem. Soc., 131, 15584, 10.1021/ja9066783

Roy, 2010, Synthetic analogs tailor native AI-2 signaling across bacterial species, J. Am. Chem. Soc., 132, 11141, 10.1021/ja102587w

Janssens, 2008, Brominated furanones inhibit biofilm formation by Salmonella enterica serovar Typhimurium, Appl. Environ. Microbiol., 74, 6639, 10.1128/AEM.01262-08

Han, 2008, Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli, Bioorg. Med. Chem. Lett, 18, 1006, 10.1016/j.bmcl.2007.12.032

Zang, 2009, A naturally occurring brominated furanone covalently modifies and inactivates LuxS, Bioorg. Med. Chem. Lett, 19, 6200, 10.1016/j.bmcl.2009.08.095

Basha, 2006, Polyvalent inhibitors of anthrax toxin that target host receptors, Proc. Natl. Acad. Sci. India, 103, 13509

Firon, 1983, Carbohydrate specificity of the surface lectins of Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium, Carbohydr. Res., 120, 235, 10.1016/0008-6215(83)88019-7

Mysore, 1999, Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound, Gastroenterology [Internet], 117, 1316, 10.1016/S0016-5085(99)70282-9

Pinkner, 2006, Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria, Proc. Natl. Acad. Sci. India, 103, 17897

Gauthier, 2005, Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli, Antimicrob. Agents Chemother., 49, 4101, 10.1128/AAC.49.10.4101-4109.2005

Kauppi, 2003, Targeting bacterial virulence: inhibitors of type III secretion in Yersinia, Chem Biol [Internet], 10, 241, 10.1016/S1074-5521(03)00046-2

Hung, 2005, Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization, Science (80-. ), 310, 670, 10.1126/science.1116739

Simpson, 2009, Selective toxin sequestrants for the treatment of bacterial infections, J. Am. Chem. Soc., 131, 5760, 10.1021/ja900852k

Kiran, 2008, Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening, Mol. Pharmacol. [Internet], 73, 1578, 10.1124/mol.107.044164

Sintim, 2010, Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules, Future Med. Chem. [Internet], 2, 1005, 10.4155/fmc.10.185

Persson, 2005, Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic, Org. Biomol. Chem. [Internet], 3, 253, 10.1039/B415761C

Rasmussen, 2005, Identity and effects of quorum-sensing inhibitors produced by Penicillium species, Microbiology, 151, 1325, 10.1099/mic.0.27715-0

Rasmussen, 2005, Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector, J. Bacteriol., 187, 1799, 10.1128/JB.187.5.1799-1814.2005

Vandeputte, 2010, Identification of catechin as one of the flavonoids from combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in pseudomonas aeruginosa PAQ1, Appl. Environ. Microbiol., 76, 243, 10.1128/AEM.01059-09

Imamura, 2004, Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-oxododecanoyl) homoserine lactone in NCI-H292 cells, Antimicrob. Agents Chemother., 48, 3457, 10.1128/AAC.48.9.3457-3461.2004

Tateda, 2001, Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa, Antimicrob. Agents Chemother., 45, 1930, 10.1128/AAC.45.6.1930-1933.2001

Ng, 2012, Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios, PLoS Pathog., 8, 10.1371/journal.ppat.1002767

Krishnan, 2012, Inhibition of quorum sensing-controlled virulence factor production in pseudomonas aeruginosa PAO1 by ayurveda spice clove (syzygium aromaticum) bud extract, Sensors, 12, 4016, 10.3390/s120404016

Pammi, 2011, Farnesol decreases biofilms of staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin, Pediatr. Res., 70, 578, 10.1203/PDR.0b013e318232a984

Nguyen, 2012, Small-molecule modulators of Listeria monocytogenes biofilm development, Appl. Environ. Microbiol., 78, 1454, 10.1128/AEM.07227-11

Mitchell, 2012, Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression, J. Antimicrob. Chemother., 67, 559, 10.1093/jac/dkr510

Truchado, 2012, Inhibition of quorum sensing (QS) in yersinia enterocolitica by an Orange extract rich in glycosylated flavanones, 8885

Yang, 2012, A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa, J. Microbiol., 50, 987, 10.1007/s12275-012-2149-7

Miandji, 2012, Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents, Arzneimittelforschung [Internet], 62, 330, 10.1055/s-0032-1312590

Ravichandiran, 2012, Structure-based virtual screening for plant-derived SdiA-selective ligands as potential antivirulent agents against uropathogenic Escherichia coli, Eur. J. Med. Chem., 48, 200, 10.1016/j.ejmech.2011.12.015

Cirioni, 2013, Quorum sensing inhibitor FS3-coated vascular graft enhances daptomycin efficacy in a rat model of staphylococcal infection, Peptides, 40, 77, 10.1016/j.peptides.2012.12.002

Zhou, 2013, Eugenol inhibits quorum sensing at sub-inhibitory concentrations, Biotechnol. Lett., 35, 631, 10.1007/s10529-012-1126-x

Wagh, 2013, Evaluation of anti-quorum sensing activity of silver nanowires, Appl. Microbiol. Biotechnol., 97, 3593, 10.1007/s00253-012-4603-1

Nakayama, 2013, Development of a peptide antagonist against fsr quorum sensing of enterococcus faecalis, ACS Chem. Biol., 8, 804, 10.1021/cb300717f

Stacy, 2013, Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators, Org. Biomol. Chem. [Internet], 11, 938, 10.1039/C2OB27155A

Brackman, 2013, Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi, Bioorg. Med. Chem., 21, 660, 10.1016/j.bmc.2012.11.055

O'Loughlin, 2013, A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation, Proc. Natl. Acad. Sci. India, 110, 17981

Maisarah Norizan, 2013, Caffeine as a potential quorum sensing inhibitor, Sensors, 13, 5117, 10.3390/s130405117

Priya, 2013, Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus, Sensors, 13, 14558, 10.3390/s131114558

Nafee, 2014, Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors, J. Contr. Release, 192, 131, 10.1016/j.jconrel.2014.06.055

Chang, 2014, Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target, Sci. Rep., 4, 10.1038/srep07245

Figueroa, 2014, Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry, J. Nat. Prod., 77, 1351, 10.1021/np5000704

Packiavathy, 2014, Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa, Food Chem., 148, 453, 10.1016/j.foodchem.2012.08.002

Sully, 2014, Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance, PLoS Pathog., 10, 10.1371/journal.ppat.1004174

Borges, 2014, Evaluation of the effects of selected phytochemicals on quorum sensing inhibition and in vitro cytotoxicity, Biofouling, 30, 10.1080/08927014.2013.852542

Brango-Vanegas, 2014, Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors, Phytomedicine, 21, 670, 10.1016/j.phymed.2014.01.001

Burt, 2014, The natural antimicrobial carvacrol inhibits quorum sensing in chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations, PLoS One, 9, 10.1371/journal.pone.0093414

Murray, 2014, Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors, J. Med. Chem., 57, 2813, 10.1021/jm500215s

Nielsen, 2014, Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils, PLoS One, 9, 10.1371/journal.pone.0084992

Pejin, 2015, In vitro anti-quorum sensing activity of phytol, Nat. Prod. Res., 29, 374, 10.1080/14786419.2014.945088

Starkey, 2014, Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity, PLoS Pathog., 10, 10.1371/journal.ppat.1004321

Kim, 2015, 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition, Sci. Rep., 5

Husain, 2015, Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria, Front. Microbiol., 6

Park, 2015, Design, synthesis and biological evaluation of 4-(alkyloxy)-6-methyl-2H-pyran-2-one derivatives as quorum sensing inhibitors, Bioorg. Med. Chem. Lett. [Internet], 25, 2913, 10.1016/j.bmcl.2015.05.054

Singh, 2015, Design, synthesis, biological evaluation and toxicity studies of N,N-disubstituted biguanides as quorum sensing inhibitors, Med. Chem. Res., 24, 1974, 10.1007/s00044-014-1255-y

Yin, 2015, Tea polyphenols as an antivirulence compound disrupt quorum-sensing regulated pathogenicity of Pseudomonas aeruginosa, Sci. Rep., 5, 10.1038/srep16158

Daly, 2015, ω-hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation, Antimicrob. Agents Chemother., 59, 2223, 10.1128/AAC.04564-14

Brackman, 2016, The quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release, Sci. Rep. [Internet], 6, 20321, 10.1038/srep20321

Fukumoto, 2016, Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025, J. Antibiot., 69, 395, 10.1038/ja.2015.126

Joshi, 2016, Plant phenolic acids affect the virulence of Pectobacterium aroidearum and P.carotovorum ssp. brasiliense via quorum sensing regulation, Mol. Plant Pathol., 17, 487, 10.1111/mpp.12295

Kang, 2016, Efficacies of quorum sensing inhibitors, piericidin A and glucopiericidin A, produced by Streptomyces xanthocidicus KPP01532 for the control of potato soft rot caused by Erwinia carotovora subsp. atroseptica, Microbiol. Res. [Internet], 184, 32, 10.1016/j.micres.2015.12.005

Kasper, 2016, Chemical inhibition of kynureninase reduces Pseudomonas aeruginosa quorum sensing and virulence factor expression, ACS Chem. Biol., 11, 1106, 10.1021/acschembio.5b01082

Luo, 2017, Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model, PLoS One, 12, 10.1371/journal.pone.0176883

Meyer, 2016, Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria, ISME J., 10, 1204, 10.1038/ismej.2015.184

Nizalapur, 2016, Design, synthesis and evaluation of N-aryl-glyoxamide derivatives as structurally novel bacterial quorum sensing inhibitors, Org. Biomol. Chem. [Internet], 14, 680, 10.1039/C5OB01973G

Ilic-Tomic, 2017, Diarylheptanoids from alnus viridis ssp viridis and alnus glutinosa: modulation of quorum sensing activity in Pseudomonas aeruginosa, Planta Med., 83, 117

Ishii, 2017, High-throughput screening of small molecule inhibitors of the Streptococcus quorum-sensing signal pathway, Sci. Rep., 7, 10.1038/s41598-017-03567-2

Jakobsen, 2017, A broad range quorum sensing inhibitor working through sRNA inhibition, Sci. Rep., 7, 10.1038/s41598-017-09886-8

Kalaiarasan, 2017, Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors, Microb. Pathog., 111, 99, 10.1016/j.micpath.2017.08.017

Kong, 2017, Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08, Arch Pharm. Res. (Seoul), 40, 25, 10.1007/s12272-016-0844-3

Muhs, 2017, Virulence inhibitors from brazilian peppertree block quorum sensing and abate dermonecrosis in skin infection models, Sci. Rep., 7, 10.1038/srep42275

Tung, 2017, Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors, Eur. J. Med. Chem., 126, 10.1016/j.ejmech.2016.11.044

Vasquez, 2017, Simplified AIP-II peptidomimetics are potent inhibitors of Staphylococcus aureus AgrC quorum sensing receptors, Chembiochem, 18, 413, 10.1002/cbic.201600516

Zhang, 2017, Ultrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition, Ultrason. Sonochem., 36, 343, 10.1016/j.ultsonch.2016.12.011

Defoirdt, 2010, Can bacteria evolve resistance to quorum sensing disruption?, PLoS Pathog., 6, 1, 10.1371/journal.ppat.1000989

Köhler, 2010, Quorum sensing inhibition selects for virulence and cooperation in pseudomonas aeruginosa, PLoS Pathog., 6, 1, 10.1371/journal.ppat.1000883

Sandoz, 2007, Social cheating in Pseudomonas aeruginosa quorum sensing, Proc. Natl. Acad. Sci. India, 104, 15876

Maeda, 2012, Quorum quenching quandary: resistance to antivirulence compounds, ISME J., 6, 493, 10.1038/ismej.2011.122