Deriving the therapeutic concentrations for clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand
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Asghari, 1995, Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants, J. Neurochem., 10.1046/j.1471-4159.1995.65031157.x
Cheng, 1973, Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 percent inhibition (I50) of an enzymatic reaction, Biochem. Pharmacol., 22, 3099, 10.1016/0006-2952(73)90196-2
Farde, 1988, Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs, Arch. Gen. Psychiatry, 45, 71, 10.1001/archpsyc.1988.01800250087012
Grandy, 1989, Cloning of the cDNA and gene for a human D2 dopamine receptor, 86, 9762
Hartley, 1978, The effect of varying 3H-spiperone concentration on its binding parameters, Life Sci., 23, 513, 10.1016/0024-3205(78)90163-7
Hruska, 1984, Estimation of the apparent affinity of the striatal dopamine receptors for the radioligand [3H]spiperone ([3H]spiroperidol), J. Neurosci. Res., 12, 571, 10.1002/jnr.490120406
Karbe, 1991, Positron emission tomography with (18F)methyl-spiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol, J. Neural Transm., 86, 163, 10.1007/BF01250702
Kawagoe, 1992, Regulation of transient dopamine concentration gradients in the microenvironment sorrounding nerve terminals in the rat striatum, Neuroscience, 51, 55, 10.1016/0306-4522(92)90470-M
Louwerens, 1993, vol. 4, 130
Malmberg, 1993, Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B and D3 receptors, Mol. Pharmacol., 43, 749
Meltzer, 1995, Plasma clozapine levels and treatment of L-DOPA-induced psychosis in Parkinson's Disease, Neuropsychopharmacology, 12, 39
Munson, 1988, An exact correction to the “Cheng-Prusoff” correction, J. Receptor Res., 8, 533, 10.3109/10799898809049010
Niznik, 1985, Dopamine D2 receptors selectively labeled by a benzamide neuroleptic: [3H]-YM-09151-2, Naunyn-Schmiedeberg's Arch. Pharmacol., 329, 333, 10.1007/BF00496365
Ross, 1991, Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism, J. Neurochem., 56, 22, 10.1111/j.1471-4159.1991.tb02557.x
Seeman, 1992, Dopamine receptor sequences. Therapeutics levels of neuroleptics occupy D2 receptors, clozapine occupies D4, Neuropsychopharmacology, 7, 261
Seeman, 1984, Dopamine receptor parameters detected by 3H-spiperone depend on tissue concentration: analysis and examples, J. Neurochem., 43, 221, 10.1111/j.1471-4159.1984.tb06700.x
Seeman, 1992, The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography, Eur. J. Pharmacol.-Mol. Pharmacol. Sect., 277, 139, 10.1016/0922-4106(92)90121-B
Terai, 1989, Comparison of [3H]YM-09151-2 with [3H]spiperone and [3H]raclopride for dopamine D-2 receptor binding to rat striatum, Eur. J. Pharmacol., 173, 177, 10.1016/0014-2999(89)90516-5
Van Tol, 1991, Cloning of the gene for a human D4 receptor with high affinity for the antipsychotic clozapine, Nature, 350, 610, 10.1038/350610a0