Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

American Association for the Advancement of Science (AAAS) - Tập 354 Số 6316 - Trang 1152-1155 - 2016
Yuki Taya1, Yasunori Ota2, Adam C. Wilkinson1,3, Ayano Kanazawa1, Hiroshi Watarai4,5, Masataka Kasai1, Hiromitsu Nakauchi1,3, Satoshi Yamazaki1
1Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
2Department of Pathology, Research Hospital, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
3Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA 94305-5461, USA.
4Division of Stem Cell Cellomics, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
5Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT), Japan Science and Technology Agency (JST), Tokyo 102-0076, Japan.

Tóm tắt

Hematopoietic stem cell maintenance requires the amino acid valine.

Từ khóa


Tài liệu tham khảo

10.1126/science.1149726

10.1182/blood-2014-02-514778

10.1038/nature12984

10.1016/S0021-9258(18)43060-8

10.1126/science.103.2682.646

10.1038/nprot.2006.447

10.1146/annurev.nu.06.070186.001143

10.1016/j.cell.2005.05.026

10.1038/35004599

10.1136/bmj.a301

10.1038/nm1296-1329

10.1073/pnas.94.10.5320

10.1126/science.101.2628.489

10.1111/j.1749-6632.1958.tb49733.x

10.1016/S0168-0102(97)00113-2

10.1073/pnas.200364497