Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

Journal of the Peripheral Nervous System - Tập 22 Số 3 - Trang 162-171 - 2017
Elliot Turkiew1, Debbie Falconer1, Nicole Reed1, Ahmet Höke1
1Department of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA

Tóm tắt

AbstractDistal axon degeneration seen in many peripheral neuropathies is likely to share common molecular mechanisms with Wallerian degeneration. Although several studies in mouse models of peripheral neuropathy showed prevention of axon degeneration in the slow Wallerian degeneration (Wlds) mouse, the role of a recently identified player in Wallerian degeneration, Sarm1, has not been explored extensively. In this study, we show that mice lacking the Sarm1 gene are resistant to distal axonal degeneration in a model of chemotherapy induced peripheral neuropathy caused by paclitaxel and a model of high fat diet induced putative metabolic neuropathy. This study extends the role of Sarm1 to axon degeneration seen in peripheral neuropathies and identifies it as a likely target for therapeutic development.

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Journal of the Peripheral Nervous System

Tập 22 Số 3

162-171

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