Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

Alt, 1992, VDJ recombination, Immunol. Today, 13, 306, 10.1016/0167-5699(92)90043-7

Anand, 1990, A 3.5 genome equivalent multi-access YAC library: construction, characterization, screening and storage, Nucl. Acids Res., 8, 1951, 10.1093/nar/18.8.1951

Anderson, 1992, The nuclear serine/threonine protein kinase DNA-PK, Crit. Rev. Eur. Gene Expression, 2, 283

Banga, 1994, Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8, Mutat. Res., 315, 239, 10.1016/0921-8777(94)90035-3

Bannister, 1993, c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro: definition of the minimal kinase recognition motif, Nucl. Acids Res., 21, 1289, 10.1093/nar/21.5.1289

Biedermann, 1991, scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair, 88, 1394

Blackwell, 1989, Mechanism and developmental program of immunoglobulin gene rearrangement in mammals, Annu. Rev. Genet., 23, 630, 10.1146/annurev.ge.23.120189.003133

Bosma, 1991, The SCID mouse mutant: definition, characterization, and potential uses, Annu. Rev. Immunol., 9, 323, 10.1146/annurev.iy.09.040191.001543

Cai, 1994, Chromosomal localization and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues, Cytogenet. Cell Genet., 65, 221, 10.1159/000133635

Dvir, 1992, Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II, 89, 11920

Dvir, 1993, Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II, J. Biol. Chem., 268, 10440, 10.1016/S0021-9258(18)82219-0

Finnie, 1995, DNA-PK activity is absent in xrs-6 cells; implications for site specific recombination and DNA double-strand break repair, 92, 320

Fulop, 1990, The scid mutation in mice causes a general defect in DNA repair, Nature, 347, 479, 10.1038/347479a0

Gellert, 1992, Molecular analysis of V(D)J recombination, Annu. Rev. Genet., 22, 425, 10.1146/annurev.ge.26.120192.002233

Getts, 1994, Absence of a Ku-like DNA end-binding activity in the xrs double-strand DNA repair deficient mutant, J. Biol. Chem., 269, 15981, 10.1016/S0021-9258(17)33960-1

Giaccia, 1985, Cell cycle-dependent repair of double-stranded DNA breaks in a gammaray sensitive Chinese hamster cell, Somat. Cell Mol. Genet., 11, 485, 10.1007/BF01534842

Gottlieb, 1993, The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, 72, 131, 10.1016/0092-8674(93)90057-W

Gottlieb, 1994, Protein kinases and DNA damage, Trends Biochem. Sci., 19, 500, 10.1016/0968-0004(94)90138-4

Hendrickson, 1991, A link between double-strand break related repair and V(D)J recombination: the scid mutation, 88, 4061

Hesse, 1987, Extra-chromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)J joining signals, Cell, 49, 775, 10.1016/0092-8674(87)90615-5

Itoh, 1993, Human chromosome 8 (p12-q22) complements radiosensitivity in severe combined immune deficiency (scid) mouse, Radiat. Res., 134, 364, 10.2307/3578198

Jackson, 1988, O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcription regulation, Cell, 55, 125, 10.1016/0092-8674(88)90015-3

Jackson, 1989, Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography, 86, 1781

Jackson, 1990, GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase, Cell, 63, 155, 10.1016/0092-8674(90)90296-Q

Jeggo, 1985, X-ray sensitive mutants of Chinese hamster ovary cell line, Mutat. Res., 145, 171

Jeggo, 1991, Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines, Mutat. Res., 254, 125, 10.1016/0921-8777(91)90003-8

Jeggo, 1992, Localization of a DNA repair gene (XRCC5) involved in double-strand break rejoining to human chromosome 2, 89, 6423

Kemp, 1984, X-ray sensitive mutants of Chinese hamster ovary cells defective in double-stranded break rejoining, Mutat. Res., 132, 189

Kienker, 1991, T cell receptor γ and δ gene junctional sequences in scid mice: excessive P nucleotide insertion, J. Exp. Med., 174, 769, 10.1084/jem.174.4.769

Kirchgessner, 1993, Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8, Cancer Res., 53, 6011

Komatsu, 1993, Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8, Hum. Mol. Genet., 7, 1031, 10.1093/hmg/2.7.1031

Kuhn, 1995, DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I, Genes Dev., 9, 193, 10.1101/gad.9.2.193

Lafaille, 1989, Junctional sequences of T cell receptor γδ genes: implication for γδ T cell lineages and for a novel intermediate of V(D)J joining, Cell, 59, 859, 10.1016/0092-8674(89)90609-0

Lewes, 1994, The mechanism s of V(D)J rejoining: lessons from molecular, immunological, and comparative analysis, Adv. Immunol., 56, 27, 10.1016/S0065-2776(08)60450-2

Lieber, 1991, Site-specific recombination in immune system, FASEB J., 5, 2934, 10.1096/fasebj.5.14.1752360

Lieber, 1988, The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination, Cell, 55, 7, 10.1016/0092-8674(88)90004-9

Malynn, 1988, The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism, Cell, 54, 453, 10.1016/0092-8674(88)90066-9

Markie, 1993, New vector for transfer of yeast artificial chromosomes to mammalian cells, Somat. Cell Mol. Genet., 19, 161, 10.1007/BF01233531

Mombaerts, 1992, RAG-1-deficient mice have no mature B and T lymphocytes, Cell, 68, 867, 10.1016/0092-8674(92)90030-G

Oettinger, 1990, RAG1 and RAG2, adjacent genes that synergistically activate V(D)J recombination, Science, 248, 1517, 10.1126/science.2360047

Pergola, 1993, V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair, Mol. Cell. Biol., 13, 3464, 10.1128/MCB.13.6.3464

Rathmell, 1994, Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks, 91, 7623

Roth, 1992, V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes, Cell, 70, 983, 10.1016/0092-8674(92)90248-B

Roth, 1993, Characterization of broken DNA molecules associated with V(D)J recombination, 90, 10788

Schlissel, 1993, Doyble-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent and cell cycle regulated, Genes Dev., 7, 2520, 10.1101/gad.7.12b.2520

Schuler, 1986, Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency, Cell, 46, 963, 10.1016/0092-8674(86)90695-1

Schuler, 1991, Coding information of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints, Eur. J. Immunol., 21, 589, 10.1002/eji.1830210309

Shinkai, 1992, RAG-2-deficient mice lack mature lymphocytes due to inability to initiate VDJ rearrangement, Cell, 68, 855, 10.1016/0092-8674(92)90029-C

Smider, 1994, Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA, Science, 266, 288, 10.1126/science.7939667

Taccioli, 1993, Impairment of V(D)J recombination in double-stranded break repair mutants, Science, 260, 207, 10.1126/science.8469973

Taccioli, 1994, A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation, J. Biol. Chem., 269, 7439, 10.1016/S0021-9258(17)37305-2

Taccioli, 1994, Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination, Science, 265, 1442, 10.1126/science.8073286

Weibezahn, 1985, Double strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants, Mutat. Res., 145, 177

Whitmore, 1989, Cell cycle responses of two X-ray sensitive mutants defective in DNA repair, Int. J. Radiat. Biol., 56, 657, 10.1080/09553008914551881