Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model

Gudjonsson, 2004, Immunopathogenic mechanisms in psoriasis, Clin. Exp. Immunol., 135, 1, 10.1111/j.1365-2249.2004.02310.x Deng, 2016, The inflammatory response in psoriasis: a comprehensive review, Clin. Rev. Allergy Immunol., 50, 377, 10.1007/s12016-016-8535-x Quaglino, 2011, Th1, Th2, Th17 and regulatory T cell pattern in psoriatic patients: modulation of cytokines and gene targets induced by etanercept treatment and correlation with clinical response, Dermatology, 22, 57, 10.1159/000330330 Austin, 1999, J. Invest. Dermatol., 113, 752, 10.1046/j.1523-1747.1999.00749.x Teunissen, 1998, Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes, J. Invest. Dermatol., 111, 645, 10.1046/j.1523-1747.1998.00347.x Gaspari, 2006, Innate and adaptive immunity and the pathophysiology of psoriasis, J. Am. Acad. Dermatol., 54, S67, 10.1016/j.jaad.2005.10.057 Stumhofer, 2010, A role for IL-27p28 as an antagonist of gp130-mediated signaling, Nat. Immunol., 11, 1119, 10.1038/ni.1957 Heinemann, 2014, IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1, Nat. Commun., 5, 3770, 10.1038/ncomms4770 Bosmann, 2013, Modulation of inflammation by interleukin-27, J. Leukoc. Biol., 94, 1159, 10.1189/jlb.0213107 Villarino, 2004, Understanding the pro- and anti-inflammatory properties of IL-27, J. Immunol., 173, 715, 10.4049/jimmunol.173.2.715 Pflanz, 2002, IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells, Immunity, 16, 779, 10.1016/S1074-7613(02)00324-2 Owaki, 2005, A role for IL-27 in early regulation of Th1 differentiation, J. Immunol., 175, 2191, 10.4049/jimmunol.175.4.2191 Murugaiyan, 2009, IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells, J. Immunol., 183, 2435, 10.4049/jimmunol.0900568 Shibata, 2010, Possible roles of IL-27 in the pathogenesis of psoriasis, J. Invest. Dermatol., 130, 1034, 10.1038/jid.2009.349 Shibata, 2013, IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions, J. Invest. Dermatol., 133, 479, 10.1038/jid.2012.313 Terao, 2013, Expression profiles of cortisol-inactivating enzyme, 11beta-hydroxysteroid dehydrogenase-2, in human epidermal tumors and its role in keratinocyte proliferation, Exp. Dermatol., 22, 98, 10.1111/exd.12075 Meulener, 2009, Decreased Srcasm expression in hyperproliferative cutaneous lesions, J. Cutan. Pathol., 36, 291, 10.1111/j.1600-0560.2008.01035.x Iwasaki, 2013, Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells, Eur. J. Immunol., 43, 1063, 10.1002/eji.201242942 Visperas, 2014, IL-27 targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice, Mucosal Immunol., 7, 625, 10.1038/mi.2013.82 van der Fits, 2009, Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis, J. Immunol., 182, 5836, 10.4049/jimmunol.0802999 Hau, 2014, Prolactin induces the production of Th17 and Th1 cytokines/chemokines in murine Imiquimod-induced psoriasiform skin, J. Eur. Acad. Dermatol. Venereol., 28, 1370, 10.1111/jdv.12295 Batten, 2008, Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells, J. Immunol., 180, 2752, 10.4049/jimmunol.180.5.2752 Batten, 2006, Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells, Nat. Immunol., 7, 929, 10.1038/ni1375 Mortezavi, 2015, Immunologic advances reveal new targets in psoriasis and psoriatic arthritis, Discov. Med., 20, 169 Eberle, 2016, Recent advances in understanding psoriasis, F1000Res, 5, 770, 10.12688/f1000research.7927.1 Cheuk, 2014, Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis, J. Immunol., 192, 3111, 10.4049/jimmunol.1302313 Nestle, 2005, Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production, J. Exp. Med., 202, 135, 10.1084/jem.20050500 Gunther, 2013, Reduction of inflammatory slan (6-sulfo LacNAc) dendritic cells in psoriatic skin of patients treated with etanercept, Exp. Dermatol., 22, 535, 10.1111/exd.12190 Fujiwara, 2012, Interleukin (IL)-17 versus IL-27: opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes, Exp. Dermatol., 21, 70, 10.1111/j.1600-0625.2011.01384.x Diveu, 2009, IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells, J. Immunol., 182, 5748, 10.4049/jimmunol.0801162 Fitzgerald, 2007, Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis, J. Immunol., 179, 3268, 10.4049/jimmunol.179.5.3268 Wang, 2014, Decreased interleukin 27 expression is associated with active uveitis in Behcet’s disease, Arthritis. Res. Ther., 16, R117, 10.1186/ar4570 Wang, 2012, Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease, Investig. Ophthalmol. Visual Sci., 53, 4668, 10.1167/iovs.12-9863 Liu, 2014, Timed action of IL-27 protects from immunopathology while preserving defense in influenza, PLoS Pathog., 10, e1004110, 10.1371/journal.ppat.1004110 Jiang, 2015, More heritability probably captured by psoriasis genome-wide association study in Han Chinese, Gene, 573, 46, 10.1016/j.gene.2015.07.029 Munir, 2015, Association analysis of GWAS and candidate gene loci in a Pakistani population with psoriasis, Mol. Immunol., 64, 190, 10.1016/j.molimm.2014.11.015