DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

Al-Khodairy, 1992, DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe, EMBO J., 11, 1343, 10.1002/j.1460-2075.1992.tb05179.x

Anderson, 1992, The nuclear serinel threonine protein kinase DNA-PK, Crit. Rev. Eukary. Gene Expr., 2, 283

Bannister, 1993, c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro: definition of the minimal kinase recognition motif, Nucl. Acids Res., 21, 1289, 10.1093/nar/21.5.1289

Bligh, 1959, A rapid method of total lipid extraction and purification, Can. J. Physiol., 37, 911, 10.1139/y59-099

Blunt, 1995, Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation, Cell, 80, 813, 10.1016/0092-8674(95)90360-7

Brown, 1994, A mammalian protein targeted by G1-arresting rapamycin-receptor complex, Nature, 369, 756, 10.1038/369756a0

Carpenter, 1993, A tightly associated serine/ threonine protein kinase regulates phosphoinositide 3-kinase activity, Mol. Cell. Biol., 13, 1657, 10.1128/MCB.13.3.1657

Carter, 1990, A DNA-activated protein kinase from HeLa cell nuclei, Mol. Cell. Biol., 10, 6460, 10.1128/MCB.10.12.6460

Dhand, 1994, PI 3-kinase is a dual speck ficityenzyme: autoregulation byan intrinsic protein-serine kinase activity, EMBO J., 13, 522, 10.1002/j.1460-2075.1994.tb06290.x

Dvir, 1992, Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II, 89, 11920

Finnie, 1995, DNA-PK activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair, 92, 320

Gottlieb, 1993, The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, 72, 131, 10.1016/0092-8674(93)90057-W

Herman, 1992, An essential role for a protein and lipid kinase complex in secretary protein sorting, Trends Cell. Biol., 2, 363, 10.1016/0962-8924(92)90048-R

Jackson, 1995, DNA double-strand break repair, V(D)J recombination: involvement, of DNA-PK, Trends Biochem. Sci., 10.1016/S0968-0004(00)89090-8

Jackson, 1990, GC box binding induces phosphorylation of Spi by a DNA-dependent protein kinase, Cell, 63, 155, 10.1016/0092-8674(90)90296-Q

Jeggo, 1995, Menage a trois: double strand break repair, V(D)J recombination and DNA-PK, Bioessays, 10.1002/bies.950171108

Jimenez, 1992, The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair, 89, 4952

Kapeller, 1994, Phosphatidylinositol 3-kinase, Bioessays, 16, 565, 10.1002/bies.950160810

Kato, 1994, An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae, Nucl. Acids Res., 22, 3104, 10.1093/nar/22.15.3104

Kozak, 1991, Structural features in eukaryotic mRNAs that modulate the initiation of translation, J. Biol. Chem., 266, 19867, 10.1016/S0021-9258(18)54860-2

Kuhn, 1995, DNAdependent protein kinase: a potent inhibitor of transcription by RNA polymerase I, Genes Dev., 9, 193, 10.1101/gad.9.2.193

Kunz, 1993, Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression, Cell, 73, 585, 10.1016/0092-8674(93)90144-F

Labhart, 1995, DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I, 92, 2934

Lees-Miller, 1990, Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen, Mol. Cell. Biol., 10, 6472, 10.1128/MCB.10.12.6472

Morozov, 1994, DNA-dependent protein kinase is activated by nicks and larger singlestranded gaps, J. Biol. Chem., 269, 16684, 10.1016/S0021-9258(19)89444-9

Okada, 1994, Blockage of chemotactic peptide-induced stimulation of neutrophils bywortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase, J. Biol. Chem., 269, 3563, 10.1016/S0021-9258(17)41900-4

Roth, 1995, How to make ends meet, Curr. Biol., 5, 496, 10.1016/S0960-9822(95)00101-1

Savitsky, 1995, A single ataxia telangiectasia gene with a product similar to PI 3-kinase, Science, 268, 1749, 10.1126/science.7792600

Seaton, 1992, Isolation and characterization of the Schizosaccharomyces pombe rad3 gene involved in the DNA damage and DNA synthesis checkpoints, Gene, 119, 83, 10.1016/0378-1119(92)90069-2

Stack, 1994, Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol specific PI 3-kinase activities, J. Biol. Chem., 269, 31552, 10.1016/S0021-9258(18)31729-0

Stephens, 1991, Pathway of phosphatidylinositol (3,4,5)-triphosphate synthesis in activated neutrophils, Nature, 351, 33, 10.1038/351033a0

Taylor, 1992, Structural framework for the protein kinase family, Annu. Rev. Cell Biol., 8, 429, 10.1146/annurev.cb.08.110192.002241

Walker, 1985, Double-stranded DNA induces the phosphorylation of several proteins including the 90,000 mol. wt. heat-shock protein in animal cell extracts, EMBO J., 4, 139, 10.1002/j.1460-2075.1985.tb02328.x

Weinert, 1994, Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair, Genes Dev., 8, 652, 10.1101/gad.8.6.652