Cytotoxic effects of daunomycin on retinal pigment epithelium in vitro

Springer Science and Business Media LLC - 1987
M. Weller1, K. Heimann1, P. Wiedemann1
1Department of Vitreoretinal Surgery, Universitäts-Augenklinik, Köln, Federal Republic of Germany

Tóm tắt

Proliferative vitreoretinopathy (PVR), the most severe complication of retinal detachment surgery and posterior segment ocular trauma, is characterized by the intraocular proliferation of non-neoplastic cells with formation of vitreal and periretinal membranes resulting in renewed traction retinal detachment. As retinal pigment epithelial (RPE) cells have been shown to play an essential role in the development of PVR, we investigated the acute and chronic effects of daunomycin on the morphology and viability of porcine RPE cells in vitro. The intense and complete inhibition of cell proliferation reported in this study adds to previous evidence that daunomycin may be useful for pharmacological treatment of human PVR.

Từ khóa


Tài liệu tham khảo

Dalmark M, Strom HM (1981) A fickian diffusion transport process with features of transport catalysis. J Gen Physiol 78:349–364

Flood MT, Gouras P, Kjeldbye H (1980) Growth characteristics and ultrastructure of human retinal pigmented epithelium in vitro. Invest Ophthalmol Vis Sci 19:1309–1320

Kampik A, Kenyon KR, Michels RG, Green WR, de la Cruz ZC (1981) Epiretinal and vitreous membranes. Comparative study of 56 cases. Arch Ophthalmol 99:1445–1454

Kirmani M, Santana M, Sorgente N, Wiedemann P, Ryan SJ (1983) Antiproliferative drugs in the treatment of experimental proliferative vitreoetinopathy: control by daunomycin. Retina 3:269–272

Machemer R, Laqua H (1975) Pigment epithelium proliferation in retinal detachment (massive periretinal proliferation). Am J Ophthalmol 80:1–23

Myers CE, Corden B, Gianni L (1984) Antitumor antibiotics. I. Anthracyclines. In: Chabner BA, Pinedo HM (eds) The cancer pharmacology annual, vol 2. Elsevier, Amsterdam, pp 66–79

Peyman GA, Schulman J (1985) Proliferative vitreoretinopathy and chemotherapeutic agents. Surv Ophthalmol 29:434–442

Santana M, Wiedemann P, Kirmani M, Minckler DS, Patterson R, Sorgente N, Ryan SJ (1984) Daunomycin in the treatment of experimental proliferative vitreoretinopathy: retinal toxicity of intravitreal daunomycin in the rabbit. Graefe's Arch Clin Exp Ophthalmol 221:210–213

Wiedemann P, Heimann K (1986a) Proliferative Vitreoretinopathie. Pathogenese und Möglichkeiten der Behandlung mit Zytostatika. Klin Monatsbl Augenheilkd 188:559–562

Wiedemann P, Heimann K (1986b) Intraocular daunomycin for the treatment of human proliferative vitreoretinopathy. III. World Conference on Clinical Pharmacology and Therapeutics. Abstracts II: 1536

Wiedemann P, Sorgente N, Bekhor C, Patterson R, Tran T, Ryan SJ (1985) Daunomycin in the treatment of experimental proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 26:719–725

Thông tin
Thông tin xuất bản

Springer Science and Business Media LLC

Thông tin tác giả