Cytokines and major depression

Olga J.G. Schiepers1, Marieke Wichers1, Michaël Maes1
1Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands

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Abe, 1999, Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain, Neurochem. Res., 24, 359, 10.1023/A:1020929415443

Adams, 1984, Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer, J. Am. Med. Assoc., 252, 938, 10.1001/jama.1984.03350070056026

Ader, 1995, Psychoneuroimmunology: interactions between the nervous system and the immune system, Lancet, 345, 99, 10.1016/S0140-6736(95)90066-7

Aloisi, 1995, Cytokine regulation of astrocyte function: in-vitro studies using cells from the human brain, Int. J. Dev. Neurosci., 13, 265, 10.1016/0736-5748(94)00071-A

Anisman, 1999, Anhedonic and anxiogenic effects of cytokine exposure, 199

Anisman, 2002, Cytokines, stress, and depressive illness, Brain Behav. Immun., 16, 513, 10.1016/S0889-1591(02)00009-0

Anisman, 1996, Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation, Brain Res., 731, 1, 10.1016/0006-8993(96)00460-X

Anisman, 1998, Differential effects of interleukin (IL)-1β, IL-2 and IL-6 on responding for rewarding lateral hypothalamic stimulation, Brain Res., 779, 177, 10.1016/S0006-8993(97)01114-1

Banks, 1995, Passage of cytokines across the blood–brain barrier, Neuroimmunomodulation, 2, 241, 10.1159/000097202

Banks, 2003, Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes, Neuroimmunomodulation, 10, 319, 10.1159/000071472

Beattie, 2002, Control of synaptic strength by glial TNF-α, Science, 295, 2282, 10.1126/science.1067859

Bernton, 1987, Release of multiple hormones by a direct action of interleukin-1 on pituitary cells, Science, 238, 519, 10.1126/science.2821620

Bonaccorso, 2000, Psychological and behavioural effects of interferon-alpha, Curr. Opin. Psychiatry, 13, 673, 10.1097/00001504-200011000-00034

Bonaccorso, 2001, Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms, Psychiatry Res., 105, 45, 10.1016/S0165-1781(01)00315-8

Borgstrom, 1982, Human leukocyte interferon and cimetidine for metastatic melanoma, N. Engl. J. Med., 307, 1080, 10.1056/NEJM198210213071716

Brebner, 2000, Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α: central monoamine, corticosterone, and behavioral variations, Neuropsychopharmacology, 22, 566, 10.1016/S0893-133X(99)00166-9

Breder, 1988, Interleukin-1 immunoreactive innervation of the human hypothalamus, Science, 240, 321, 10.1126/science.3258444

Breder, 1993, Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine and central nervous system, J. Comp. Neurol., 337, 543, 10.1002/cne.903370403

Calogero, 1988, Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vivo, J. Clin. Invest., 82, 839, 10.1172/JCI113687

Capuron, 2001, Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy, Psychoneuroendocrinology, 26, 797, 10.1016/S0306-4530(01)00030-0

Capuron, 2002, Neurobehavioural effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions, Neuropsychopharmacology, 26, 643, 10.1016/S0893-133X(01)00407-9

Capuron, 2002, Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy, Mol. Psychiatry, 7, 468, 10.1038/sj.mp.4000995

Capuron, 2002, Treatment of cytokine-induced depression, Brain Behav. Immun., 16, 575, 10.1016/S0889-1591(02)00007-7

Castanon, 2002, Effects of antidepressants on cytokine production and actions, Brain Behav. Immun., 16, 569, 10.1016/S0889-1591(02)00008-9

Chandler, 1997, Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview, J. Neuroimmunol., 72, 155, 10.1016/S0165-5728(96)00179-8

Crane, 2003, Evidence that the bed nucleus of the stria terminalis contributes to the modulation of hypophysiotropic corticotropin-releasing factor cell responses to systemic interleukin-1β, J. Comp. Neurol., 467, 232, 10.1002/cne.10918

Cserr, 1992, Cervical lymphatics, the blood–brain barrier and the immunoreactivity of the brain: a new view, Immunol. Today, 13, 507, 10.1016/0167-5699(92)90027-5

Cupps, 1982, Corticosteroid-mediated immunoregulation in man, Immunol. Rev., 65, 133, 10.1111/j.1600-065X.1982.tb00431.x

Dantzer, 2001, Cytokine-induced sickness behaviour: mechanisms and implications, Ann. N.Y. Acad. Sci., 933, 222, 10.1111/j.1749-6632.2001.tb05827.x

Dantzer, 1999, Mechanisms of the behavioral effects of cytokines, 83

Dantzer, 1999, Cytokines, stress and depression. Conclusions and perspectives, 317

De Beaurepaire, 2002, Questions raised by the cytokine hypothesis of depression, Brain Behav. Immun., 16, 610, 10.1016/S0889-1591(02)00005-3

Dunn, 1999, Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress, 117

Dursun, 2001, An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap, Med. Hypotheses, 56, 235, 10.1054/mehy.2000.1187

Felten, 1991

Fertuzinhos, 2004, Analysis of IL-1α, IL-1β, and IL-1RA polymorphisms in dysthymia, J. Mol. Neurosci., 22, 251, 10.1385/JMN:22:3:251

Freidin, 1992, Cultured sympathetic neurons synthesize and release the cytokine interleukin-β, Proc. Natl. Acad. Sci., 89, 10440, 10.1073/pnas.89.21.10440

Friedman, 2001, Cytokines regulate expression of the type 1 interleukin-1 receptor in rat hippocampal neurons and glia, Exp. Neurol., 168, 23, 10.1006/exnr.2000.7595

Hall, 1996, Investigating the effects and altereffects of naturally occurring upper respiratory tract illnesses on mood and performance, Physiol. Behav., 59, 569, 10.1016/0031-9384(95)02112-4

Harbuz, 1992, The effects of recombinant human interleukin (IL)-1 alpha, IL-1 beta or IL-6 on hypothalamo–pituitary–adrenal axis activation, J. Endocrinol., 133, 349, 10.1677/joe.0.1330349

Harbuz, 1996, Interleukin-1 beta-induced effects on plasma oxytocin and arginine vasopressin: role of adrenal steroids and route of administration, Neuroimmunomodulation, 3, 358, 10.1159/000097296

Heyes, 1992, Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease, Brain, 115, 1249, 10.1093/brain/115.5.1249

Irwin, 1999, Immune correlates of depression, 1

Irwin, 1987, Impaired natural killer cell activity among depression patients, Psychiatry Res., 20, 181, 10.1016/0165-1781(87)90010-2

Janeway, 1997

Jun, 2003, Possible association between-G308A tumour necrosis factor-α gene polymorphism and major depressive disorder in the Korean population, Psychiatr. Genet., 13, 179, 10.1097/00041444-200309000-00008

Kronfol, 2000, Cytokines and the brain: implications for clinical psychiatry, Am. J. Psychiatry, 157, 683, 10.1176/appi.ajp.157.5.683

Kronfol, 1983, Impaired lymphocyte function in depressive illness, Life Sci., 33, 241, 10.1016/0024-3205(83)90382-X

Kubera, 2000, Serotonin–immune interactions in major depression, 79

Kubera, 1995, The effect of chronic treatment with imipramine on the immunoreactivity of animals subjected to a chronic mild stress model of depression, Immunopharmacology, 30, 225, 10.1016/0162-3109(95)00026-P

Lacosta, 2000, Central monoamine activity following acute and repeated systemic interleukin-2 administration, Neuroimmunomodulation, 8, 83, 10.1159/000026457

Leonard, 2001, The immune system, depression and the action of antidepressants, Prog. Neuro-psychopharmacol. Biol. Psychiatry, 25, 767, 10.1016/S0278-5846(01)00155-5

Leonard, 1999, Stress, depression, and the role of cytokines, 251

Linthorst, 1998, Brain neurotransmission during peripheral inflammation, Ann. N.Y. Acad. Sci., 840, 139, 10.1111/j.1749-6632.1998.tb09558.x

Linthorst, 1999, Inflammation and brain function under basal conditions and during long-term elevation of brain corticotropin-releasing hormone levels, 129

Linthorst, 1995, Effect of bacterial endotoxin and interleukin-1β on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study, J. Neurosci., 15, 2920, 10.1523/JNEUROSCI.15-04-02920.1995

Luine, 1994, Steroid hormone influences on spatial memory, Ann. N.Y. Acad. Sci., 743, 201, 10.1111/j.1749-6632.1994.tb55793.x

Maes, 1995, Evidence for an immune response in major depression: a review and hypothesis, Prog. Neuro-psychopharmacol. Biol. Psychiatry, 19, 11, 10.1016/0278-5846(94)00101-M

Maes, 1999, Major depression and activation of the inflammatory response system, 25

Maes, 1995, Increased plasma concentrations of interleukin-6, soluble interleukin-6 receptor, soluble interleukin-2 receptor and transferrin receptor in major depression, J. Affect. Disord., 34, 301, 10.1016/0165-0327(95)00028-L

Maes, 2002, Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation, Life Sci., 71, 1837, 10.1016/S0024-3205(02)01853-2

Maier, 1998, Cytokines for psychologists: implications for bidirectional immune-to-brain communication for understanding behavior, mood, and cognition, Psychol. Rev., 105, 83, 10.1037/0033-295X.105.1.83

Mangoni, 1974, The ‘kynurenine shunt’ and depression, Adv. Biochem. Psychopharmacol., 11, 293

McGeer, 1995, The inflammatory response system of the brain: implications for therapy of Alzheimer and other neurodegenerative diseases, Brain Res. Rev., 21, 195, 10.1016/0165-0173(95)00011-9

Meijer, 1988, Post-influenzal psychiatric disorder in adolescents, Acta Psychiatr. Scand., 78, 176, 10.1111/j.1600-0447.1988.tb06319.x

Merali, 1997, Effects of interleukin-1β and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study, Brain Res., 761, 225, 10.1016/S0006-8993(97)00312-0

Merali, 2003, Dissociating anorexia and anhedonia elicited by interleukin-1β: antidepressant and gender effects on responding for ‘free chow’ and ‘earned’ sucroseintake, Psychopharmacology (Berl.), 165, 413, 10.1007/s00213-002-1273-1

Merrill, 1997, Inflammatory events at the blood brain barrier: regulation of adhesion molecules, cytokines, and chemokines by reactive nitrogen and oxygen species, Brain Behav. Immun., 11, 245, 10.1006/brbi.1997.0496

Meyers, 1999, Mood and cognitive disorders in cancer patients receiving cytokine therapy, 75

Miller, 1999, Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression, 107

Mossner, 1998, Enhancement of serotonin transporter function by tumor necrosis factor alpha but not by interleukin-6, Neurochem. Int., 33, 251, 10.1016/S0197-0186(98)00026-6

Müller, 1998, Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders, Prog. Neuro-psychopharmacol. Biol. Psychiatry, 22, 1, 10.1016/S0278-5846(97)00179-6

Munoz-Fernandez, 1998, The role of tumour necrosis factor, interleukin-6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system, Prog. Neurobiol., 56, 307, 10.1016/S0301-0082(98)00045-8

Murphy, 1991, Steroids and depression, J. Steroid Biochem. Mol. Biol., 38, 537, 10.1016/0960-0760(91)90312-S

Musselman, 2001, Paroxetine for the prevention of depression and neurotoxicity induced by high dose interferon-α, N. Engl. J. Med., 344, 961, 10.1056/NEJM200103293441303

Neveu, 1999, Is there evidence for an effect of antidepressant drugs on immune function?, 267

Newcomer, 1999, Decreased memory performance in healthy humans induced by stress-level cortisol treatment, Arch. Gen. Psychiatry, 56, 527, 10.1001/archpsyc.56.6.527

Nunes, 2002, Immune and hormonal activity in adults suffering from depression, Braz. J. Med. Biol. Res., 35, 581, 10.1590/S0100-879X2002000500011

O'Connor, 2000, The stress response and the hypothalamic–pituitary–adrenal axis: from molecule to melancholia, Q. J. Math, 93, 323

Pauli, 1998, Tumour necrosis factor-α and interleukin-2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic–pituitary–adrenocortical axis activity in the rat, Eur. J. Neurosci., 10, 868, 10.1046/j.1460-9568.1998.00093.x

Plaut, 1987, Lymphocyte hormone receptors, Annu. Rev. Immunol., 5, 621, 10.1146/annurev.iy.05.040187.003201

Pollak, 2000, Behavioral aspects of experimental autoimmune encephalomyelitis (EAE), J. Neuroimmunol., 104, 31, 10.1016/S0165-5728(99)00257-X

Pollmächer, 2002, Low levels of circulating inflammatory cytokines—do they affect human brain functions?, Brain Behav. Immun., 16, 525, 10.1016/S0889-1591(02)00004-1

Ramamoorthy, 1995, Regulation of human serotonin transporter by interleukin-1 beta, Biochem. Biophys. Res. Commun., 216, 560, 10.1006/bbrc.1995.2659

Ressler, 1999, Role of norepinephrine in the pathophysiology and treatment of mood disorders, Biol. Psychiatry, 46, 1219, 10.1016/S0006-3223(99)00127-4

Ressler, 2000, Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders, Depress. Anxiety, 12, S2, 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4

Riedel, 2002, Tryptophan, mood, and cognitive function, Brain Behav. Immun., 16, 581, 10.1016/S0889-1591(02)00013-2

Rogler, 1998, Cytokines in inflammatory bowel disease, World J. Surg., 22, 382, 10.1007/s002689900401

Rosa, 2004, Interleukin-1beta (IL-1β) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders, Am. J. Med. Genet., 124B, 10, 10.1002/ajmg.b.20074

Rothermundt, 2001, Inflammatory markers in major depression and melancholia, J. Affect. Disord., 63, 93, 10.1016/S0165-0327(00)00157-9

Rothermundt, 2001, Different immune patterns in melancholic and non-melancholic major depression, Eur. Arch. Psychiatry Clin. Neurosci., 251, 90, 10.1007/s004060170058

Sakic, 1996, Blunted sensitivity to sucrose in autoimmune MRL-1pr mice: a curve shift study, Brain Res. Bull., 41, 305, 10.1016/S0361-9230(96)00190-6

Sapolsky, 1985, The development of the glucocorticoid receptor in the rat limbic system: III. Negative-feedback regulation, Brain Res., 350, 169, 10.1016/0165-3806(85)90261-5

Sapolsky, 1987, Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor, Science, 238, 522, 10.1126/science.2821621

Schildkraut, 1965, The cathecholamine hypothesis of affective disorders: a review of supporting evidence, Am. J. Psychiatry, 122, 509, 10.1176/ajp.122.5.509

Schomburg, 1994, Hepatic and serologic toxicity of systemic interleukin-2 and/or interferon-α. Evidence of a risk-benefit advantage of subcutaneous therapy, Am. J. Clin. Oncol., 17, 199, 10.1097/00000421-199406000-00004

Seidel, 1999, Cytokine production in depressed patients, 47

Shepherd, 1994

Shepherd, 1994

Smith, 1991, The macrophage theory of depression, Med. Hypotheses, 35, 298, 10.1016/0306-9877(91)90272-Z

Song, 2002, The effect of thymectomy and IL-1 on memory: implications for the relationship between immunity and depression, Brain Behav. Immun., 16, 557, 10.1016/S0889-1591(02)00012-0

Song, 1994, An acute phase response in the olfactory bulbectomised rat: effect of sertraline treatment, Med. Sci. Res., 22, 313

Song, 1999, Variations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatment, Neuroscience, 88, 823, 10.1016/S0306-4522(98)00271-1

Stone, 2001, Kynurenines in the CNS: from endogenous obscurity to therapeutic importance, Prog. Neurobiol., 64, 185, 10.1016/S0301-0082(00)00032-0

Stone, 2002, Endogenous kynurenines as targets for drug discovery and development, Nat. Rev., 1, 609, 10.1038/nrd870

Tilders, 1999, Cross-sensitization between immune and non-immune stressors. A role in the etiology of depression?, 179

Tracey, 2002, The inflammatory reflex, Nature, 420, 853, 10.1038/nature01321

Utsuyama, 2002, Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice, Exp. Gerontol., 37, 411, 10.1016/S0531-5565(01)00208-X

Van der Vliet, 1992, Effect of oxidative stress on receptors and signal transmission, Chem. Biol. Interact., 85, 95, 10.1016/0009-2797(92)90055-P

Van Gool, 1999, Management of psychiatric adverse events with immunotherapy with interferon-alfa, Acta Neuropsychiatr., 11, 120, 10.1017/S0924270800035857

Vespasiani Gentilucci, 2002, Liver cirrhosis after prolonged therapy with IFN-α plus interleukin-2 in a metastatic renal cell cancer long-term survivor, J. Interferon Cytokine Res., 22, 683, 10.1089/10799900260100178

Watkins, 1995, Cytokine-to-brain communication: a review and analysis of alternative mechanisms, Life Sci., 57, 1011, 10.1016/0024-3205(95)02047-M

Watkins, 1999, Dynamic regulation of proinflammatory cytokines, 153

Weinblatt, 1999, A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate, N. Engl. J. Med., 340, 253, 10.1056/NEJM199901283400401

Weizman, 1994, Cytokine production in major depressed patients before and after clomipramine treatment, Biol. Psychiatry, 35, 42, 10.1016/0006-3223(94)91166-5

Wichers, 2002, The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans, Int. J. Neuropsychopharmacol., 5, 375, 10.1017/S1461145702003103

Wichers, 2004, The role of indoleamine 2,3 dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression, J. Psychiatry Neurosci., 29, 11

Wild, 1994

Xu, 1999, The central amygdala modulates hypothalamic–pituitary–adrenal axis responses to systemic interleukin-1β administration, Neuroscience, 94, 175, 10.1016/S0306-4522(99)00311-5

Yirmiya, 1996, Endotoxin produces a depressive-like episode in rats, Brain Res., 711, 163, 10.1016/0006-8993(95)01415-2

Yirmiya, 2000, Depression in medical illness, West. J. Med., 173, 333, 10.1136/ewjm.173.5.333

Yirmiya, 1999, Cytokines, ‘depression due to a general medical condition’ and antidepressant drugs, 283

Yirmiya, 2000, Illness, cytokines, and depression, Ann. N.Y. Acad. Sci., 917, 478, 10.1111/j.1749-6632.2000.tb05412.x

Young, 1985, Tryptophan depletion causes a rapid lowering of mood in normal males, Psychopharmacology, 87, 173, 10.1007/BF00431803

Young, 1991, Loss of glucocorticoid fast feedback in depression, Arch. Gen. Psychiatry, 48, 693, 10.1001/archpsyc.1991.01810320017003