Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity

Soll, 1991, Nonsteroidal anti-inflammatory drugs and peptic ulcer disease, Ann Intern Med, 114, 307, 10.7326/0003-4819-114-4-307

Wallace, 1997, Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years, Gastroenterology, 112, 1000, 10.1053/gast.1997.v112.pm9041264

Xie, 1992, Mitogen-inducible prostaglandin G/H synthase: a new target for nonsteroidal antiinflammatory drugs, Drug Dev Res, 25, 249, 10.1002/ddr.430250402

DeWitt, 1993, PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs, Am J Med, 95, 40S, 10.1016/0002-9343(93)90396-7

Vane, 1994, Towards a better aspirin, Nature, 367, 215, 10.1038/367215a0

Kargman, 1996, Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts, Gastroenterology, 111, 448, 10.1053/gast.1996.v111.pm8690211

Vane, 1994, Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation, Proc Natl Acad Sci USA, 91, 2046, 10.1073/pnas.91.6.2046

Masferrer, 1994, Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic, Proc Natl Acad Sci USA, 91, 3228, 10.1073/pnas.91.8.3228

Leblanc, 1995, Synthesis and biological evaluation of 2,3-diarylthiopenes as selective COX-2 and COX-1 inhibitors, Bioorg Med Chem, 5, 2123, 10.1016/0960-894X(95)00359-2

Glaser, 1995, Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1, Eur J Pharmacol, 281, 107, 10.1016/0014-2999(95)00302-2

Wong, 1997, Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2–selective inhibitors by a double His513 → Arg and Ile523 →Val mutation, J Biol Chem, 272, 9280, 10.1074/jbc.272.14.9280

Brideau, 1996, A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors, Inflamm Res, 45, 68, 10.1007/BF02265118

Meade, 1993, Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs, J Biol Chem, 268, 6610, 10.1016/S0021-9258(18)53294-4

Mitchell, 1993, Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase, Proc Natl Acad Sci USA, 90, 11693, 10.1073/pnas.90.24.11693

Seibert, 1994, Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain, Proc Natl Acad Sci USA, 91, 12013, 10.1073/pnas.91.25.12013

Chan, 1995, Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach, J Pharmacol Exp Ther, 274, 1531

Dinchuk, 1995, Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II, Nature, 378, 406, 10.1038/378406a0

Wallace, 1993, Tissue-selective inhibition of prostaglandin synthesis in rat by tepoxalin: anti-inflammatory without gastropathy, Gastroenterology, 105, 1630, 10.1016/0016-5085(93)91057-O

Patrignani, 1994, Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases, J Pharmacol Exp Ther, 271, 1705

Reuter, 1996, Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2, J Clin Invest, 98, 2076, 10.1172/JCI119013

Xie, 1991, Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing, Proc Natl Acad Sci USA, 88, 2692, 10.1073/pnas.88.7.2692

Yamada, 1993, Mechanisms of acute and chronic inflammation induced by indomethacin, Inflammation, 17, 641, 10.1007/BF00920471

Morham, 1995, Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse, Cell, 83, 473, 10.1016/0092-8674(95)90125-6

Mizuno, 1997, Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice, Gastroenterology, 112, 387, 10.1053/gast.1997.v112.pm9024292

Nakatsugi, 1996, Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats, Prostaglandins Leukot Essent Fatty Acids, 55, 395, 10.1016/S0952-3278(96)90122-2

Whittle, 1981, Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat, Gastroenterology, 80, 94, 10.1016/0016-5085(81)90196-7

Rainsford, 1982, Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production, Dig Dis Sci, 27, 624, 10.1007/BF01297219

Whittle, 1983, The potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclo-oxygenase inhibitors, Br J Pharmacol, 80, 545, 10.1111/j.1476-5381.1983.tb10727.x

Whittle, 1990, Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat, Br J Pharmacol, 99, 607, 10.1111/j.1476-5381.1990.tb12977.x