Curling of Hair in Two Female Patients Taking Alitretinoin
Tóm tắt
Two female patients aged 45 and 51 years experienced curling of hair during treatment with alitretinoin (Toctino®). For one patient, the indication for use was severe chronic hand eczema, but for the second patient the indication was not reported. After 5 and 9 months, respectively, the patients developed hair texture changes and their straight hair began to curl. The dose of alitretinoin was reduced in both cases, but the patients’ hair had not straightened at the time of reporting (9 months and 2 years after onset of the event). Based on the described reports received by the Netherlands Pharmacovigilance Centre Lareb, the case reports in the literature, and the possible mechanisms, we suggest a causal relationship between curling of the hair and the use of alitretinoin. Using the World Health Organization Uppsala Monitoring Centre (WHO-UMC) system for standardized case causality assessment, the association in our cases can be assessed as likely.
Tài liệu tham khảo
Dutch SmPC Toctino® 10 mg capsules (version date: 18-7-2017) [in Dutch]. Available at: https://db.cbg-meb.nl/IB-teksten/h100957.pdf. Accessed 4 Jun 2018.
UK SPC Toctino 10 mg and 30 mg capsules (version date: 15-8-2017). Available at: https://www.medicines.org.uk/emc/medicine/21177/SPC/Toctino+10mg+and+30mg+soft+capsules/. Accessed 16 Jun 2018.
Dutch SmPC Isotretinoïne 10 mg capsules (version date: 25-11-2016) [in Dutch]. Available at: https://db.cbg-meb.nl/IB-teksten/h26547.pdf. Accessed 4 Jun 2018.
Dutch SmPC Acitretine (Neotigason®) 10 mg capsules (version date: 11-10-2016). Available at: https://db.cbg-meb.nl/IB-teksten/h13103.pdf. Accessed 4 Jun 2018.
Tosti A, Piraccini BM, Pazzaglia M. Acquired progressive kinking of the hair—clinical features, pathological study, and follow-up of 7 patients. Arch Dermatol. 1999;135(10):1223–6.
Herink C, Schön MP, Mößner R. Development of curly hair under systemic therapy with alitretinoin. Hautarzt. 2015;66(8):617–9.
Joshi RS. The inner root sheath and the men associated with it eponymically. Int J Trhichology. 2011;3(1):57–62.
Mahrle G, Orfanos CE, Ippen H, Hofbauer M. Haarwachstum, leberwerte und lichtempfindlichkeit unter oraler retinoid-therapie bei psoriasis. Deutsche Medizinishe Wochenschrift. 1979;104:473–7.
Kolesnik M, Gollnick H, Bonnekoh B. Complete remission of alopecia areata under treatment of chronic hand eczema with alitretinoin. Eur J Dermatol. 2013;23(1):110–1.
Graham RM, James MP, Ferguson DJ, Guerrier CW. Acquired kinking of the hair associated with etretinate therapy. Clin Exp Dermatol. 1985;10(5):426–31.
Up-To-Date. Clinical manifestations of hypothyroidism. Available at: https://www.uptodate.com/contents/clinical-manifestations-of-hypothyroidism?search=hypothyroidism&source=search_result&selectedTitle=3~150&usage_type=default&display_rank=3. Accessed 14 Jun 2018.
Trehan P, Wilson NJ. Alitretinoin-induced curling of the hair. Australas J Dermatol. 2016;57(2):155.
Clarke JT, Price H, Clarke S, George R, Miller JJ. Acquired kinking of the hair caused by acitretin. J Drugs Dermatol. 2007;6(9):937–8.
Seckin D, Yildiz A. Repigmentation and curling of hair after acitretin therapy. Australas J Dermatol. 2009;50(3):214–6.
Tosti A, Pazzaglia M. Drug reactions affecting hair: diagnosis. Dermatol Clin. 2007;252(2):223–31.
Ward PD, Miller HL, Shipman AR. A case of repigmentation and curling of hair on acitretin therapy. Clin Exp Dermatol. 2014;39(1):91–2.
Bunker CB, Maurice PD, Dowd PM. Isotretinoin and curly hair. Clin Exp Dermatol. 1990;15(2):143–5.
Hays SB, Camisa C. Acquired pili torti in two patients treated with synthetic retinoids. Cutis. 1985;35(5):466–8.
Van der Pijl JW, Bavinck JN, de Fijter JW. Isotretinoin and azathioprine: a synergy that makes hair curl? Lancet. 1996;348(9027):622–3.
Archer CB, Cerio R, Griffiths WAD. Etretinate and acquired kinking of the hair. Clin Exp Dermatol. 1987;12:239.
Mortimer PS. Unruly hair. Br J Dermatol. 1985;113(4):467–73.
Schauder S, Tsambaos D, Nikiforidis G. Curling and kinking of hair caused by etretinate. Hautarzt. 1992;42(8):509–13.
Van Beek N, Bodó E, Kromminga A. Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab. 2008;93(11):4381–8.
World Health Organisation—the Uppsala Monitoring Centre. The use of the WHO-UMC system for standardized case causality assessment. Available at: http://www.who.int/medicines/areas/quality_safety/safety_efficacy/WHOcausality_assessment.pdf. Accessed 21 Jun 2018.