Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis

Head & Neck Oncology - Tập 1 Số 1 - 2009
Sunil K Pandya1, Ajay Kumar Chaudhary2, Mamta Singh1, Magan Singh3, Ravi Mehrotra1
1Departments of Pathology, Moti Lal Nehru Medical College, Allahabad, India
2Centre for Biotechnology, University of Allahabad, India
3Otorhinolayngology, Moti Lal Nehru Medical College, Allahabad, India

Tóm tắt

Abstract Background Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF). Methods Patients suffering from oral submucous fibrosis from the Departments of Otorhinolayngology and Pathology, Moti Lal Nehru Medical College, Allahabad, India were studied from 2004–2008. Detailed information was gathered in a pretested proforma. Emphasis was given to the various addictions, clinical findings and histological examination was done. Results Two hundred and thirty nine patients were studied, yielding a male to female ratio of 6.8:1. Maximum patients were in the 21–30 years age group with a marked male predominance. Of these, 197 (82.4%) patients chewed areca nut/dohra, 14 (5.8%) were smokers and 2 (0.8%) patients were habituated to alcohol. 89(37.2%) patients reported difficulty in opening of the mouth (trismus). 51 (57.4%) patients were found to have stage II (2–3 cm) trismus while rest had stage I and III. The buccal mucosa was found to be the most commonly involved site. On the basis of histopathological examination, 52(21.7%) were classified as OSF grade I, 75(31.3%) patients as grade II and 112(46.8%) had grade III disease. Conclusion The widespread habit of chewing dohra/paan masala is a major risk factor of OSF, especially in the younger age group. In this study, an increase in histopathological grading was found with severity and duration of addiction habit. However no significant correlation was found between clinical staging and histopathological grading.

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Head & Neck Oncology

Tập 1 Số 1

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