Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3→p31.3 by nonisotopic in situ hybridization

Cytogenetic and Genome Research - Tập 69 Số 3-4 - Trang 232-234 - 1995
William S. Modi1, William L. Farrar2, O. M. Zack Howard3
1Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp., NCI-Frederick Cancer Research and Development Center
2Biological Response Modifiers Program, NCI-Frederick Cancer Research and Development Center
3Biological Response Modifiers Program, Program Resources, Inc./Dyncorp, NCI-Frederick Cancer Research and DevelopmentCenter, Frederick, MD (USA)

Tóm tắt

JAK1A is a recently isolated class 3 (nonreceptor) tyrosine kinase that has catalytic domain sequence homology with other kinases and is known to be ubiquitously expressed in all human tissues thus far examined. The gene for this enzyme had previously been localized to chromosome 1 using somatic cell hybrids and linkage analyses. In the present study, fluorescence in situ hybridization was utilized to confirm its localization and regionally assign the gene to chromosome region 1p32.3→p31.3.

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Cytogenetic and Genome Research

Tập 69 Số 3-4

232-234

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