Complexities for Assessment and Treatment of Co-Occurring ADHD and Tics

Centers for Disease Control and Prevention. Prevalence of diagnosed tourette syndrome in persons aged 6–17 years—United States, 2007. MMWR. 2009;58(21):581–5.

Khalifa N, Von Knorring AL. Psychopathology in a Swedish population of school children with tic disorders. J Am Acad Child Adolesc Psychiatry. 2006;45(11):1346–53.

Spencer T, Biederman J, Wilens T. Attention-deficit/hyperactivity disorder and comorbidity. Ped Clin North Am. 1999;46(5):915–27.

Kurlan R, Como PG, Miller B, et al. The behavioral spectrum of tic disorders: a community-based study. Neurology. 2002;59(3):414–20.

Debes NM, Hjalgrim H, Skov L. The presence of comorbidity in Tourette syndrome increases the need for pharmacological treatment. J Child Neurol. 2009;24(12):1504–12.

Storch EA, Merlo LJ, Lack C, et al. Quality of life in youth with Tourette’s syndrome and chronic tic disorder. J Clin Child Adolesc Psychol. 2007;36(2):217–27.

Rizzo R, Gulisano M, Cali PV, et al. Long term clinical course of Tourette syndrome. Brain Dev. 2012;34(8):667–73.

Sukhodolsky DG, Landeros-Weisenberger A, Scahill L, Leckman JF, Schultz RT. Neuropsychological functioning in children with Tourette syndrome with and without attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010;49(11):1155–64.

Lebowitz R, Motlagh MG, Katsovich L, et al. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. Europ Child Adolesc Psychiatr. 2012;21(8):451–7.

Budman CL, Bruun RD, Park KS, et al. Explosive outbursts in children with Tourette’s disorder. J Am Acad Child Adolesc Psychiatry. 2000;39(10):1270–6.

Wolf SS, Jones DW, Knable MB, et al. Tourette syndrome: prediction of phenotypic variation in monozygotic twins by caudate nucleus D2 receptor binding. Science. 1996;273:1225–7.

Peterson BS, Choi HA, Hao X, et al. Morphologic features of the amygdala and hippocampus in children and adults with Tourette syndrome. Arch Gen Psychiatry. 2007;64(11):1281–91.

Amat JA, Bronen RA, Saluja S, et al. Increased number of subcortical hyperintensities on MRI in children and adolescents with Tourette’s syndrome, obsessive-compulsive disorder, and attention deficit hyperactivity disorder. Am J Psychiatry. 2006;163(6):1106–8.

Price RA, Kidd KK, Cohen DJ, et al. A twin study of Tourette syndrome. Arch Gen Psychiatry. 1985;42:815–20.

Scharf JM, Yu D, Mathews CA, et al. Genome-wide association study of Tourette’s syndrome. Mol Psychiatry. 2013;18(6):721–8.

Hawi Z, Cummins TD, Tong J, et al. The molecular genetic architecture of attention deficit hyperactivity disorder. Mol Psychiatry. 2015;20(3):289–97.

Gomez L, Wigg K, Zhang K, et al. Association of the KCNJ5 gene with Tourette syndrome and attention-deficit/hyperactivity disorder. Genes Brain Behav. 2014;13(6):535–42.

Malhany NEI, Gulisano M, Rizzo R, et al. Tourette syndrome and comorbid ADHD: causes and consequences. Eur J Pediatr. 2015;174(3):279–88. A comprehensive review of prevalence, neurobiology, genetics, and treatment of Tourette’s Disorder and ADHD.

Pringsheim T, Lang A, Kurlan R, et al. Understanding disability in Tourette syndrome. Dev Med Child Neurol. 2009;51(6):468–72.

Motlagh MG, Katsovich L, Thompson N, et al. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome. Eur Child Adolesc Psychiatry. 2010;19(10):755–64.

Spencer T, Biederman J, Coffey BJ, et al. The four-year course of tic disorders in boys with attention deficit hyperactivity disorder. Arch Gen Psychiatry. 1999;56:842–7.

Spencer TJ, Biederman J, Faraone S, et al. Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD. Am J Psychiatry. 2001;158:611–7.

Gorman DA, Thompson N, Plessen KJ, et al. Psychosocial outcome and psychiatric comorbidity in older adolescents with Tourette syndrome: controlled study. Br J Psychiatry. 2010;197(1):36–44.

Freeman RD. Tourette Syndrome International Database Consortium. Tic disorders and ADHD: answers from a world-wide clinical dataset on Tourette syndrome. Eur Child Adolesc Psychiatry 2007;Suppl 1:15–23. Erratum in: Eur Child Adolesc Psychiatry 2007;16(8):536.

Rizzo R, Curatolo P, Gulisano M, et al. Disentangling effects of Tourette syndrome and ADHD on cognitive and behavioral phenotypes. Brain Dev. 2007;29:413–20.

Haddad AD, Umoh G, Bhatia V, et al. Adults with Tourette’s syndrome with and without attention deficit hyperactivity disorder. Acta Psychiatr Scand. 2009;120(4):299–307.

Yale Child Study Center. YGTSS: Yale Global Tic Severity Scale [Measurement instrument]. 1992.

Achenbach T. Manual for the child behavior checklist/2-3 and 1992 Profile [Measurement instrument]. 1992.

Swanson, JM. SNAP-IV: Swanson, Nolan and Pelham teacher and parent rating scale [Measurement instrument]. 2013.

CYBOCS: Children’s Yale-Brown obsessive-compulsive scale [Measurement instrument]. 1989.

March JS, Parker JD, Sullivan K, Stallings P, Conners KC. The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity. J Am Acad Child Adolesc Psychiatry. 1997;36(4):554–65.

Poznanski EO, Grossman JA, Buchsbaum Y, Banegas M, Freeman L, Gibbons R. Preliminary studies of the reliability and validity of the children’s depression rating scale. J Am Acad Child Adolesc Psychiatry. 1984;23(2):191–7.

Pliszka S, The AACAP. Work group on quality issues. practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894–921.

Murphy T, Lewin A, Storch E, Stock S. Practice parameter for the assessment and treatment of children and adolescents with tic disorders. J Am Acad Child Adolesc Psychiatry. 2013;52(12):1341–59. Recent review and guidelines by the American Academy of Child and Adolescent Psychiatry for treatment of Tic Disorders, including comorbid disorders such as ADHD.

Faraone S, Buitelar J. Comparing the efficacy of stimulants in ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry. 2010;19(4):353–64.

Lowe TL, Cohen DJ, Detlor J, et al. Stimulant medications precipitate Tourette’s syndrome. JAMA. 1982;247(12):1729–31.

Gadow KD, Sverd J, Sprafkin J, et al. Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. Arch Gen Psychiatry. 1995;52(6):444–55.

Tourette’s Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002;58(4):527–36.

Castellanos X, Giedd J, Elia J, et al. Controlled stimulant treatment of ADHD and comorbid Tourette’s syndrome: effects of stimulant and dose. J Am Acad Child Adolesc Psychiatry. 1997;36:589–96.

Bloch MH, Panza KE, Landeros-Weisenberger A, et al. Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. J Am Acad Child Adolesc Psychiatry. 2009;48(9):884–93.

Steingard R, Biederman J, Spencer T, et al. Comparison of clonidine response in the treatment of attention-deficit hyperactivity disorder with and without comorbid tic disorders. J Am Acad Child Adolesc Psychiatry. 1993;32(2):350–3.

Scahill L, Erenberg G, Berlin Jr CM, et al. Tourette Syndrome Association Medical Advisory Board: Practice Committee. contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx. 2006;3(2):192–206. Review.

Boon-yasidhi V, Kim YS, Scahill L. An open-label, prospective study of guanfacine in children with ADHD and tic disorders. J Med Assoc Thai. 2005;88(8):S156–62.

Chappell PB, Riddle MA, Scahill L, et al. Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette’s syndrome: preliminary clinical experiences. J Am Acad Child Adolesc Psychiatry. 1995;34:1140–6.

Du YS, Li HF, Vance A, Zhong YQ, Jiao FY, Wang HM, et al. Randomized double-blind, multicentre placebo-controlled clinical trial of the clonidine adhesive patch for the treatment of tic disorders. Aust N Z J Psychiatry. 2008;42(9):807–1.

Weisman H, Qureshi I, Leckman J, Scahill L, Bloch M. Systematic review: pharmacological treatment of tic disorders: efficacy of antipsychotic and alpha 2 agonist agents. Neurosci Biobehav R. 2013;37:1162–71. Comprehensive meta-analysis of antipsychotic and alpha agonist medications in treatment of tic disorders. Results demonstrated significant benefit of both medication classes, but indicated ADHD moderates response to alpha-agonists.

Allen AJ, Kurlan RM, Gilbert DL, et al. Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders. Neurology 2005;27;65(12):1941–9.

Spencer TJ, Sallee FR, Gilbert DL, et al. Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome. J Atten Disord. 2008;11(4):470–81.

Spencer T, Biederman J, Kerman K, et al. Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry. 1993;32(2):354–60.

Spencer T, Biederman J, Coffey B, et al. A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2002;59:649–56.

Singer HS, Brown J, Quaskey S, et al. The treatment of attention-deficit hyperactivity disorder in Tourette’s syndrome: a double-blind placebo-controlled study with clonidine and desipramine. Pediatrics. 1995;95(1):74–81.

Biederman J, Baldessarini RJ, Wright V, et al. A double-blind placebo controlled study of desipramine in the treatment of ADD: I. Efficacy. J Am Acad Child Adolesc Psychiatry. 1989;28(5):777–84.

Olfson M, King M, Schoenbaum M. Treatment of young people with antipsychotic medications in the United States. JAMA Psychiatry 2015 Jul 1. doi: 10.1001/jamapsychiatry.2015.0500 .

Bruggeman R, Van der Linden C, Buitelaar JK, et al. Risperidone versus pimozide in Tourette’s disorder: a comparative double-blind parallel-group study. J Clin Psychiatry. 2001;62(1):50–6.

Sallee FR, Kurlan R, Goetz CG, et al. Ziprasidone treatment of children and adolescents with Tourette’s disorder: a pilot study. J Am Acad Child Adolesc Psychiatry. 2000;39:292–99.

Yoo HK, Joung YS, Lee JS, et al. A Multicenter, randomized, double blind, placebo controlled study of Aripiprazole in children and adolescents with Tourette’s Disorder. J Clinical Psych 2013;74(8)(9):e772-80.

Gabbay V, Babb JS, Klein RG, et al. A double-blind, placebo-controlled trial of ω-3 fatty acids in Tourette’s disorder. Pediatrics. 2012;129(6):e1493–500.

Bloch M, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatr. 2011;50(10):991–1000.

Kurlan R, Crespi G, Coffey B, et al. Pramipexole for TS trial investigators. a multicenter randomized placebo-controlled clinical trial of pramipexole for Tourette’s syndrome. Mov Disord. 2012;27(6):775–8.

Neuner I, Podoll H, Janouschek H, et al. From psychosurgery to neuromodulation: deep brain stimulation for intractable Tourette syndrome. World J Biol Psychiatry. 2009;10(4 Pt 2):366–76.

Azrin NH, Nunn RG. Habit-reversal: a method of eliminating nervous habits and tics. Behav Res Ther. 1973;11(4):619–28.

Piacentini J, Woods DW, Scahill L, et al. Behavior therapy for children with Tourette disorder: a randomized controlled trial. JAMA. 2010;303(19):1929–37.