Comparison of the pharmacological effects ofPanax ginsengandPanax quinquefolium

Acta Pharmacologica Sinica - Tập 29 Số 9 - Trang 1103-1108 - 2008
Chieh-fu Chen1, Wen-Fei Chiou2, Jun-Tian Zhang3
1Institute of Pharmacology, National Yang-Ming University, Taipei, China
2National Research Institute of Chinese Medicine, Taipei, China
3Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China

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Tài liệu tham khảo

1 ZhaoHZ, editor. Cyclopedia of Panax ginseng and American ginseng. Hong Kong: Rong-Zhai Publishers; 1998. p 9. [In Chinese].

2 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2006. p. 587-91.[In Chinese].

Kiangsu Institute of Modern Medicine, 1977, Encyclopedia of Chinese Drug, 29

State Administration of Traditional Chinese Medicine of the People's Republic of China, 1996, Zhong-Hua-Ben-Cao, 1269

5 ZhaoHZ, editor. Cyclopedia of Panax ginseng and American ginseng. Hong Kong: Rong-Zhai Publishers; 1998. p 249. [In Chinese].

6 ZhaoHZ, editor. Cyclopedia of Panax ginseng and American ginseng. Hong Kong: Rong-Zhai Publishers; 1998. p 223, p 231. [In Chinese].

Court, 1996, Influence of root age on the concentration of ginsenosides of American ginseng (Panax quinque-folium), Can J Plant Sci, 76, 853, 10.4141/cjps96-144

Tanaka, 1984, Progress in chemistry of organic natural products, 1

Yang, 1988, Chemotaxanomic studies and the utilization of Panax species, Acta Bot Yunnanica, 1, 47

10 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2006. p 486-7. [In Chinese].

Wang, 2007, Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolium roots, Planta Med, 73, 669, 10.1055/s-2007-981524

Assinewe, 2003, Phytochemistry of wild populations of Panax quinquefolium (North American ginseng), J Agric Food Chem, 51, 4549, 10.1021/jf030042h

Schlag, 2006, Ginsenoside content and variation among and within American ginseng (Panax quinquefolium L.) populations, Phytochemistry, 67, 1510, 10.1016/j.phytochem.2006.05.028

Wills, 2002, Changes in ginsenosides in Australian-grown American ginseng plants (Panax quinquefolium L.), Aust J Exp Agric, 42, 1119, 10.1071/EA01191

Cui, 1995, Identification and quantification of ginsenosides in various commercial ginseng preparations, Eur J Pharmacol Sci, 3, 77, 10.1016/0928-0987(94)00077-D

Ma, 1996, Distribution and proportion of major ginsenosides and quality control of ginseng products, Chin J Med Chem, 6, 11

Popovich, 2004, Generation of ginsenosides Rg3 and Rh2 from North American ginseng, Phytochemistry, 65, 337, 10.1016/j.phytochem.2003.11.020

Li, 2000, Use of high-performance liquid chromatography-tandem mass spec-trometry to distinguish Panax ginseng L.A. Meyer (Asian ginseng) and Panax quinquefolium L. (North American ginseng), Anal Chem, 72, 5417, 10.1021/ac000650l

19 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2002. p 547-553. [In Chinese].

20 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2002. p 544. [In Chinese].

21 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2002. p 554, p 555. [In Chinese].

22 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2002. p 546. [In Chinese].

23 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2002. p 557. [In Chinese].

24 LiFY, editor. Panax ginseng and American ginseng. Beijing: Chinese Agriculture Scientech Press; 2002. p 577. [In Chinese].

Chang, 2008, Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals (synaptosomes), Eur J Pharmacol, 578, 28, 10.1016/j.ejphar.2007.09.023

26 ZhangJT, ChuiDH, Chen CF, editors. The chemistry metabolism and biological activities of ginseng. Beijing: Chemical Industry Press; 2006.

Nah, 2007, Ginsenosides: are any of them candidates for drugs acting on the central nervous system, J Compil, 13, 381

Tian, 2005, Neuroprotective effect of 20(s)-ginsenoside Rg3 on cerebral ischemia in rats, Neurosci Lett, 374, 92, 10.1016/j.neulet.2004.10.030

Wu, 2007, Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia, Intern Immnuopharmacol, 7, 312

Radad, 2006, Use of ginseng in medicine with emphasis on neurodegenerative disorders, J Pharmacol Sci, 100, 175, 10.1254/jphs.CRJ05010X

Chow, 1976, Pharmacological studies on Chinese herbs with potential hypotensive, analgesic and/or antipyretic effects, Natl Sci Coun Month, 4, 2341

Jeon, 2000, Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats, Gen Pharmacol, 35, 135, 10.1016/S0306-3623(01)00096-9

Han, 1998, Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension, Am J Chin Med, 26, 199, 10.1142/S0192415X98000257

Sung, 2000, Effects of red ginseng upon vascular endothelial function in patients with essential hypertension, Am J Chin Med, 28, 205, 10.1142/S0192415X00000258

Kang, 1995, Ginsenosides of the protopa-naxatriol group cause endothelium-dependent relaxation in the rat aorta, Life Sci, 56, 1577, 10.1016/0024-3205(95)00124-O

Chen, 1996, Cardiovascular protection by ginsenosides and their nitric oxide releasing action, Clin Exp Pharmacol Physiol, 23, 728, 10.1111/j.1440-1681.1996.tb01767.x

Kim, 2003, Gin-senoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase, Br J Pharmacol, 140, 661, 10.1038/sj.bjp.0705490

Nakajima, 1998, The effect of ginseng radius rubra on human vascular endothelial cells, Am J Chin Med, 26, 365, 10.1142/S0192415X98000403

Sengupta, 2004, Modulating angiogenesis: the yin and the yang in ginseng, Circulation, 110, 1219, 10.1161/01.CIR.0000140676.88412.CF

Park, 1996, Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation, Biol Pharm Bull, 19, 1434, 10.1248/bpb.19.1434

Lim, 1997, Protection of ischaemic hippocampal neuron by ginsenosides Rb1, a.main ingredient of ginseng root, Neurosci Res, 28, 191, 10.1016/S0168-0102(97)00041-2

Liu, 2002, Effect of ginsenoside Rb 1 and Re on cardiomyocyte apoptosis after ischemia and reperfusion in rats, Chin J Histochem Cytochem, 11, 374

Smolinsk, 2003, Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(l)(ginseng) and parthenolide (feverfew), Food Chem Toxicol, 41, 1381, 10.1016/S0278-6915(03)00146-7

Sun, 2007, Protective effects of ginsenoside Rbl, ginsenoside Rgl, and notoginsenoside Rl on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery, Life Sci, 81, 509, 10.1016/j.lfs.2007.06.008

Ro, 1998, Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions, Int J Immunopharmacol, 20, 625, 10.1016/S0192-0561(98)00062-9

Keum, 2003, Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion, Mutat Res, 523524, 75, 10.1016/S0027-5107(02)00323-8

Park, 2005, Inhibitory effect of ginsenoside Rb 1 and compound K on NO and prosta-glandin E2 biosynthesis of RAW 264.7 cells induced by lipopolysac-charide, Biol Pharm Bull, 28, 652, 10.1248/bpb.28.652

Shin, 2000, The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence, Cancer Causes Control, 11, 565, 10.1023/A:1008980200583

Yun, 2001, Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds, J Korean Med Sci, 16, S6, 10.3346/jkms.2001.16.S.S6

Popovich, 2002, Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line, Arch Biochem Biophys, 406, 1, 10.1016/S0003-9861(02)00398-3

Popovich, 2003, Ginsenosides can inhibit proliferation and induce apoptosis in cultured leukemia and intestinal cells but effects vary according to the structure of the compounds, FASEB J, 17, A762

Helms, 2004, Cancer prevention and therapeutics: Panax ginseng, Alter Med Rev, 9, 259

Yoo, 2006, Effects of ginseng on the proliferation of human lung fibroblasts, Am J Chin Med, 34, 137, 10.1142/S0192415X06003709

Sohn, 1998, Effect of petroleum of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells, Exp Mol Med, 30, 47, 10.1038/emm.1998.7

Suzuki, 1989, Mechanisms of hypoglycaemic activity of pa-naxans A and B, glycans of Panax ginseng roots: effects on plasma level, secretion, sensitivity and binding of insulin in mice, Phytother Res, 3, 20, 10.1002/ptr.2650030106

Takaku, 1990, Studies on insulin-like substances in Korea red ginseng, Planta Med, 56, 27, 10.1055/s-2006-960877

Tchilian, 1991, Effect of ginsenoside Rgl on insulin binding in mice liver and membranes, Phytother Res, 5, 46, 10.1002/ptr.2650050114

Sotaniemi, 1995, Ginseng therapy in non-insulin dependent diabetic patients, Diabetes Care, 18, 1373, 10.2337/diacare.18.10.1373

Attele, 2002, Antidi-abetic effects of Panax ginseng berry extract and the identification of an effective component, Diabetes, 5, 1851, 10.2337/diabetes.51.6.1851

Xie, 2002, Ginseng berry reduces blood glucose and body weight in db/db mice, Phyto-medicine, 9, 254, 10.1078/0944-7113-00106

Dey, 2003, Antihypergly-cemic effects of ginseng: comparison between root and berry, Phyto-medicine, 10, 600, 10.1078/094471103322331908

Xie, 2004, American ginseng leaf: ginsenoside analysis and hypoglycemic activity, Pharmacol Review, 49, 113

Xie, 2005, An-tidiabetic effect of ginsenoside Re in db/db mice, Biochim Biophys Acta, 1740, 319, 10.1016/j.bbadis.2004.10.010

Xie, 2005, Ginseng and diabetes, Am J Chin Med, 33, 397, 10.1142/S0192415X05003004

Cho, 2006, Ginsenoside Re of Panax ginseng possesses significant an-tioxidant and antihypelipidemic efficacies in streptozotocin-induced diabetic rats, Eur J Pharmacol, 550, 173, 10.1016/j.ejphar.2006.08.056

Cho, 2006, Altered expression of serum protein in ginsenoside Re-treated diabetic rats defected by SELDI-TOF MS, J Ethnopharmacol, 108, 272, 10.1016/j.jep.2006.05.009

Chan, 2002, Estrogen-like activity of ginsenoside Rgl derived from Panax notoginseng, J Clin Endocrinol Metab, 87, 3691, 10.1210/jcem.87.8.8717

Lee, 2003, Ginsenoside-Rhl, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells, J Steroid Biochem Mol Biol, 84, 463, 10.1016/S0960-0760(03)00067-0

Cho, 2004, Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-α and β, independent of ligand binding, J Clin Endocrinol Metab, 89, 3510, 10.1210/jc.2003-031823

Bae, 2005, Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect, Biol Pharm Bull, 28, 1903, 10.1248/bpb.28.1903

Nakaya, 2007, The phytoestrogen ginsenoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways, J Med Invest, 54, 381, 10.2152/jmi.54.381

Yu, 2007, Signaling pathway of nitric oxide production induced by ginsenoside Rbl in human aortic endothelial cells: A possible involvement of androgen receptor, Bichem Biophys Res Commu, 353, 764, 10.1016/j.bbrc.2006.12.119

Huang, 2005, A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration, Pharm Res, 22, 636, 10.1007/s11095-005-2500-3

Yue, 2007, Pharmacogenomics and the Yin/Yang actions of ginseng: antitumor, angiomodulating and steroid-like activities of ginsenosides, Chin Med, 2, 6, 10.1186/1749-8546-2-6

Sato, 1994, Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2, Biol Pharm Bull, 17, 635, 10.1248/bpb.17.635

Mochizuki, 1995, Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)-and 20(S)-ginsenoside-Rg3, of red ginseng, Biol Pharm Bull, 18, 1197, 10.1248/bpb.18.1197

Shinkai, 1996, Inhibition of in vitro tumor cell invasion by ginsenoside Rg3, Jpn J Cancer Res, 87, 357, 10.1111/j.1349-7006.1996.tb00230.x

Tao, 2002, Effect of angiogenesis inhibitor Rg3 on the growth and metastasis of gastric cancer in SCID mice, Zhoughua Waike Zazhi, 40, 606

Kang, 2002, Experimental study on anti-angiogenesis in mice with Lewis lung carcinoma by low-dose of cyclophosphamide combined with ginsenoside Rg3, Zhongguo Zhongxiyi Jiehe Zazhi, 25, 730