Comparison of bone marrow dosimetry and toxic effect of high dose 131I-labeled monoclonal antibodies administered to man

Steven M Larson1, Andrew Raubitschek2, James C Reynolds1, Ronald D Neumann1, Karl-Erik Hellstrom3, Ingegerd Hellstrom3, David Colcher4, Jeffrey Schlom4, Eli Glatstein2, Jorge A Carrasquillo1
1Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, U.S.A.
2Radiation Oncology Branch, National Cancer Institute, Bethesda, Md, U.S.A.
3Oncogen, Seattle, Washington, U.S.A.
4Laboratory of Tumor Immunology and Biology National Cancer Institute, Bethesda, Md, U.S.A.

Tài liệu tham khảo

Appelbaum, 1987, Treatment of preleukemic syndromes with marrow transplantation, Blood, 69, 92, 10.1182/blood.V69.1.92.92 Benua, 1962, The relation of radioiodine dosimetry to results and complications in the treatment of metastatic thyroid cancer, Cancer, 87, 171 Carrasquillo, 1984, Diagnosis and therapy with radiolabeled monoclonal antibodies and immune fragments, Cancer Treatment Rep, 68, 317 Carrasquillo, 1988, Peritoneal carcinomatosis: imaging with intraperitoneal injection of I-131 labeled B72.3 monoclonal antibody, Radiology, 167, 35, 10.1148/radiology.167.1.3347742 Colcher, 1987, Quantitative analyses of selective radiolabeled monoclonal antibody localization in metastatic lesions of colorectal cancer patients, Cancer Res., 47, 1185 Ferens, 1984, High level iodination of monoclonal antibodies for radiotherapy, J. Nucl. Med., 25, 367 Finch, 1987, Acute radiation syndrome, J. Am. Med. Assoc., 258, 684, 10.1001/jama.1987.03400050106037 Keller, 1946, A clinical syndrome following exposure to atomic bomb explosions, J. Am. Med. Soc., 131, 504 FitzGerald, 1986, Radio-sensitivity of human bone marrow granulocyte-macrophage progenitor cells and stromal colony-forming cells: effect of dose rate, Radiat. Res, 107, 205, 10.2307/3576808 Larson, 1983, Localization of I-131-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy, J. Clin. Invest., 72, 2101, 10.1172/JCI111175 Larson, 1985, Preliminary clinical experience using an I-131 labeled murine Fab against a high molecular weight antigen of human melanoma, Radiology, 155, 487, 10.1148/radiology.155.2.3983400 Larson, 1986, A tentative biological model for the localization of radiolabeled antibody in tumor: the importance of immunoreactivity, Nucl. Med. Biol., 13, 393 Larson, 1987, Lymphoma, melanoma, colon cancer: diagnosis and treatment with radiolabeled monoclonal antibodies, Radiology, 165, 297, 10.1148/radiology.165.2.3498971 Snyder, 1975, “S” absorbed dose per unit cumulated activity for selected radionuclides and organs, 1 Thomas, 1959, The diagnosis and management of accidental radiation injury, J. Occup. Med., 1, 421 Thomas, 1970, Technique for human marrow grafting, Blood, 36, 507, 10.1182/blood.V36.4.507.507 Yokoyama, 1987, Immunoreactivity affects the biodistribution and tumor targetting of radiolabeled anti-p97 Fab fragment, J. Nucl. Med., 28, 651