Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds

Journal of wound care - Tập 24 Số 10 - Trang 459-465 - 2015
Yunes Panahi1, Morteza Izadi2, N. Sayyadi3, Ramin Rezaee4, Nematollah Jonaidi Jafari2, Fatemeh Beiraghdar5, Ali Zamani1, Amirhossein Sahebkar6,7
1Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3Pharmaceutical Consultant, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
4Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
5Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
6Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
7Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

Tóm tắt

Objective: Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera–olive oil (AVO) combination cream on the healing process of chronic wounds. Method: In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS). Results: After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001). Conclusion: AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream.

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Tài liệu tham khảo

10.3390/molecules13081599

10.1177/1534734603002001006

10.1016/j.ymeth.2007.03.004

10.1016/j.burns.2006.10.384

Yadav K.C., 2012, Int J Pharma and Bio Sciences, 3, 63

10.1079/NRR200495

10.1016/j.clindermatol.2008.01.008

10.1100/tsw.2006.333

10.2337/diacare.14.10.909

McAnally L.E., 1992, Hosp Pharm, 27, 649

10.1111/j.1365-4362.1993.tb02799.x

Anstead G.M., 1996, Ann Pharmacol, 30, 768, 10.1177/106002809603000712

10.1345/aph.10267

Bhatia A., 2004, Dermatol Online J, 10, 5, 10.5070/D30Z3612W1

10.1111/j.1365-2133.2007.08160.x

10.1258/acb.2012.012040

Bedi M.K., 2002, Arch Dermatol, 138, 232

Panahi Y., 2012, Asian Biomed, 6, 273

10.3109/15569527.2011.633950

10.1136/bmj.332.7546.900

10.1016/j.clindermatol.2009.05.015

10.1097/WON.0b013e3181d73aab

10.1017/S0007114511006544

10.3109/15569527.2011.614669

10.1016/S0024-3205(97)01150-8

10.1093/molehr/gap109

Al-Waili N., 2003, FASEB J, 17, 342

Akh U., 1999, Usp Fiziol Nauk, 30, 54

10.1016/j.redox.2014.07.001

10.1254/jphs.08204FP

10.1016/S0378-8741(97)00124-4

10.1292/jvms.10-0438

10.1088/1748-6041/7/3/035008

Oryan A., Ann Plast Surg

Rahmani N., 2014, Eur Rev Med Pharmacol Sci, 18, 1078

10.1089/acm.2009.0428

Molazem Z., 2014, Glob J Health Sci, 7, 203, 10.5539/gjhs.v7n1p203

10.1055/s-2002-35666

10.1016/S0378-8741(96)01476-6

Tungala A., 2011, J Phytol, 3, 1

Thông tin
Thông tin xuất bản

Journal of wound care

Tập 24 Số 10

459-465

Thông tin tác giả