Combination of Vaccine Strain Measles Virus and Nimotuzumab in the Treatment of Laryngeal Cancer

NGUYEN LINH TOAN1, NGO THU HANG1,2, NGUYEN KIM LUU3, CAN VAN MAO1, NGUYEN VAN BA3, NGUYEN THI XUAN4, TRUONG DINH CAM5, NAOKI YAMAMOTO6, HOANG VAN TONG7,1, HO ANH SON7,1
1Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam
2Ha Dong Medical College, Hanoi, Vietnam
3103 Military Hospital, Vietnam Military Medical University, Hanoi, Vietnam
4Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam
5175 Military Hospital, Ho Chi Minh, Vietnam
6Department of Microbiology, Yong loo lin School of Medicine, National University of Singapore, Singapore, Singapore
7Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam

Tóm tắt

Background/Aim: This study aims to investigate whether the combination of oncolytic viruses with chemoradiotherapy or other therapies is a promising strategy for cancer treatment. Materials and Methods: The anticancer effects of measles virus (MeV) in combination with nimotuzumab in the treatment of laryngeal cancer were evaluated in vitro and in nude mice inoculated with Hep2 tumors. MTT assay and flow cytometry were used to examine cell death. Results: Laryngeal cancer cells treated with MeV+nimotuzumab combination had a significantly lower survival rate compared to those treated with MeV or nimotuzumab alone (p<0.0001). In an animal model bearing human laryngeal tumor, the treated group had a higher survival rate (60%) compared to a untreated group (20%) (p<0.05), and the survival rate of the group treated with MeV+nimotuzumab combination was higher compared to the groups received single treatment. Conclusion: The MeV+nimotuzumab combination has greater anticancer activities in both laryngeal cancer cells and an animal model.

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