Clonal expansion of IgA-positive plasma cells and axon-reactive antibodies in MS lesions

Altschul, 1997, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res., 25, 3389, 10.1093/nar/25.17.3389

Banham, 1997, The plasma cell associated antigen detectable by antibody VS38 is the p63 rough endoplasmic reticulum protein, J. Clin. Pathol., 50, 485, 10.1136/jcp.50.6.485

Baranzini, 1999, B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions, J. Immunol., 163, 5133, 10.4049/jimmunol.163.9.5133

Barnes, 1991, The longstanding MS lesion. A quantitative MRI and electron microscopic study, Brain, 114, 1271, 10.1093/brain/114.3.1271

Ben-Nun, 1981, Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein, Nature, 292, 60, 10.1038/292060a0

Budka, 1985, Occurrence of IgA subclasses (IgA1 and IgA2) in the human nervous system. Correlation with disease, Int. Arch. Allergy Appl. Immunol., 76, 107, 10.1159/000233675

Colombo, 2000, Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients, J. Immunol., 164, 2782, 10.4049/jimmunol.164.5.2782

Da, 2004, Polyclonal B-cell expansion in the cerebrospinal fluid of patients with psedotumor cerebri, J. Clin. Immunol., 24, 674, 10.1007/s10875-004-6242-5

Esiri, 1977, Immunoglobulin-containing cells in multiple-sclerosis plaques, Lancet, 2, 478, 10.1016/S0140-6736(77)91603-8

Esiri, 1980, Poliomyelitis: immunoglobulin-containing cells in the central nervous system in acute and convalescent phases of the human disease, Clin. Exp. Immunol., 40, 42

Ferguson, 1997, Axonal damage in acute multiple sclerosis lesions, Brain, 120, 393, 10.1093/brain/120.3.393

Genain, 1999, Identification of autoantibodies associated with myelin damage in multiple sclerosis, Nat. Med., 5, 170, 10.1038/5532

Giles, 1990, Cerebrospinal fluid oligoclonal IgM in multiple sclerosis: analytical problems and clinical limitations, Ann. Clin. Biochem., 27, 199, 10.1177/000456329002700304

Griffin, 1981, Immunoglobulins in the cerebrospinal fluid: changes during acute viral encephalitis in mice, J. Immunol., 126, 27, 10.4049/jimmunol.126.1.27

Griffiths, 1984, Somatic mutation and the maturation of immune response to 2-phenyl oxazolone, Nature, 312, 271, 10.1038/312271a0

Hanahan, 1985, 109

Henriksson, 1985, IgM, IgA and IgG producing cells in cerebrospinal fluid and peripheral blood in multiple sclerosis, Clin. Exp. Immunol., 62, 176

Lamoureux, 1966, Immune studies in multiple sclerosis, Clin. Exp. Immunol., 1, 363

Leary, 2000, Local synthesis of IgA in the cerebrospinal fluid of patients with neurological diseases, J. Neurol., 247, 609, 10.1007/s004150070129

Lefranc, 2003, IMGT, the international ImMunoGeneTics database, Nucleic Acids Res., 31, 307, 10.1093/nar/gkg085

Link, 1971, Immunoglobulins in multiple sclerosis and infections of the nervous system, Arch. Neurol., 25, 326, 10.1001/archneur.1971.00490040052007

Lolli, 1989, Intrathecal synthesis of IgG, IgA, IgM and IgD in untreated multiple sclerosis and controls, Acta Neurol. Scand., 80, 238, 10.1111/j.1600-0404.1989.tb03869.x

Lucchinetti, 2000, Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination, Ann. Neurol., 47, 707, 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q

Martin, 1993, Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis, Ann. Neurol., 34, 524, 10.1002/ana.410340405

Mingioli, 1978, Quantitation of IgG, IgA and IgM in the CSF by radioimmunoassay, Neurology, 28, 991, 10.1212/WNL.28.10.991

Nerenberg, 1978, Cerebrospinal fluid IgG, IgA, IgM, IgD, and IgE levels in central nervous system disorders, Neurology, 28, 988, 10.1212/WNL.28.10.988

Nossal, 1992, The molecular and cellular basis of affinity maturation in the antibody response, Cell, 68, 1, 10.1016/0092-8674(92)90198-L

Olsson, 1973, Immunoglobulin abnormalities in multiple sclerosis. Relation to clinical parameters: exacerbations and remissions, Arch. Neurol., 28, 392, 10.1001/archneur.1973.00490240052009

Oste, 1988, Polymerase chain reaction, BioTechniques, 6, 162

Owens, 1998, Restricted use of V(H)4 germline segments in an acute multiple sclerosis brain, Ann. Neurol., 43, 236, 10.1002/ana.410430214

Qin, 1998, Clonal expansion and somatic hypermutation of V-H genes of B cells from cerebrospinal fluid in multiple sclerosis, J. Clin. Invest., 102, 1045, 10.1172/JCI3568

Qin, 2003, Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis, Lab. Invest., 83, 1081, 10.1097/01.LAB.0000077008.24259.0D

Saiki, 1988, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase, Science, 239, 487, 10.1126/science.2448875

Sena, 1997, Multiple sclerosis and intrathecal IgA synthesis, Acta Neurol. Belg., 97, 36

Siekevitz, 1987, Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses, Cell, 48, 757, 10.1016/0092-8674(87)90073-0

Tibbling, 1977, Principles of albumin and IgG analyses in neurological disorders: I. Establishment of reference values, Scand. J. Clin. Lab. Invest., 37, 385, 10.3109/00365517709091496

Tindall, 1988, Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase, Biochemistry, 27, 6008, 10.1021/bi00416a027

Tourtellotte, 1970, On cerebrospinal fluid immunoglobulin-G (IgG) quotients in multiple sclerosis and other diseases. A review and a new formula to estimate the amount of IgG synthesized per day by the central nervous system, J. Neurol. Sci., 10, 279, 10.1016/0022-510X(70)90156-5

Trapp, 1998, Axonal transection in the lesions of multiple sclerosis, N. Engl. J. Med., 338, 278, 10.1056/NEJM199801293380502

Walsh, 1986, Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis, J. Exp. Med., 163, 41, 10.1084/jem.163.1.41

Yuki, 1990, Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis, Neurology, 40, 1900, 10.1212/WNL.40.12.1900

Zhang, 1998, Rheumatoid factor specificity of a VH3-encoded antibody is dependent on the heavy chain CDR3 region and is independent of protein A binding, J. Immunol., 161, 2284, 10.4049/jimmunol.161.5.2284

Zhang, 2005, Axon reactive B Cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosis, J. Clin. Immunol., 25, 252, 10.1007/s10875-005-4083-5