Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis

Microbes and Infection - Tập 8 Số 12-13 - Trang 2772-2776 - 2006
Kingsley C. Anukam1,2,3, Emmanuel O Osazuwa3, Gibson I. Osemene4, Felix Ehigiagbe5, Andrew W. Bruce6, Gregor Reid6,7,8
1Chidak Medical Diagnostic Laboratories, 200 M.M. Way, Benin City, Nigeria
2Department of Microbiology, Faculty of Basic and Applied Sciences, Benson Idahosa University, P.M.B. 1100, Benin City, Nigeria
3Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Nigeria
4Ben-Gib Clinic and Maternity, 134 M.M. Way Benin City/Military Base Hospital, Airport Road, Benin City, Nigeria
5Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Nigeria
6Canadian Research & Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
7Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
8Department of Surgery, University of Western Ontario, London, Ontario, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Devillard, 2005, Complexity of vaginal microflora as analyzed by PCR denaturing gradient gel electrophoresis in a patient with recurrent bacterial vaginosis, Infect. Dis. Obstet. Gynecol., 13, 25, 10.1155/2005/607474

Hillier, 2005, The complexity of microbial diversity in bacterial vaginosis, N Engl. J. Med., 353, 1886, 10.1056/NEJMp058191

Fredricks, 2005, Molecular identification of bacteria associated with bacterial vaginosis, N. Engl. J. Med., 353, 1899, 10.1056/NEJMoa043802

French, 2006, Readily treatable reproductive tract infections and preterm birth among black women, Am. J. Obstet. Gynecol., 194, 1717, 10.1016/j.ajog.2006.03.004

Donder, 2002, Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis, BJOG, 109, 34, 10.1111/j.1471-0528.2002.00432.x

Cauci, 2002, Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis, J. Infect. Dis., 185, 1614, 10.1086/340417

Hapsari, 2006, Clinical characteristics of vaginal discharge in bacterial vaginosis diagnosed by Nugent's criteria, Clin. Exp. Obstet. Gynecol., 33, 5

Bradshaw, 2006, High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence, J. Infect. Dis., 193, 1478, 10.1086/503780

Austin, 2005, Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole, J. Clin. Microbiol., 43, 4492, 10.1128/JCM.43.9.4492-4497.2005

Sobel, 2006, Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis, Am. J. Obstet. Gynecol., 194, 1283, 10.1016/j.ajog.2005.11.041

Ness, 2006, Variability of bacterial vaginosis over 6- to 12-month intervals, Sex Transm. Dis., 33, 381, 10.1097/01.olq.0000204748.89222.33

Myer, 2005, Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study, J. Infect. Dis., 192, 1372, 10.1086/462427

Cherpes, 2003, Risk factors for infection with herpes simplex virus type 2: role of smoking, douching, uncircumcised males, and vaginal flora, Sex Transm. Dis., 30, 405, 10.1097/00007435-200305000-00006

Cadieux, 2002, Lactobacillus strains and vaginal ecology, JAMA, 287, 1940, 10.1001/jama.287.15.1940

Reid, 2001, Oral probiotics can resolve urogenital infections, FEMS Immunol. Med. Microbiol., 30, 49, 10.1111/j.1574-695X.2001.tb01549.x

Reid, 2003, Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women, FEMS Immunol. Med. Microbiol., 35, 131, 10.1016/S0928-8244(02)00465-0

Nugent, 1991, Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation, J. Clin. Microbiol., 29, 297, 10.1128/jcm.29.2.297-301.1991

Anukam, 2006, Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial, Microbes Infect., 8, 1450, 10.1016/j.micinf.2006.01.003

Marrazzo, 2004, Evolving issues in understanding and treating bacterial vaginosis, Expert Rev. Anti Infect. Ther., 2, 913, 10.1586/14789072.2.6.913

Reid, 1994, Implantation of Lactobacillus casei var rhamnosus into vagina, Lancet., 344, 1229, 10.1016/S0140-6736(94)90543-6

Morelli, 2004, Utilization of the intestinal tract as a delivery system for urogenital probiotics, J. Clin. Gastroenterol., 38, S107, 10.1097/01.mcg.0000128938.32835.98

Burton, 2003, Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation, Appl. Environ. Microbiol., 69, 97, 10.1128/AEM.69.1.97-101.2003

Klebanoff, 2004, Vulvovaginal symptoms in women with bacterial vaginosis, Obstet. Gynecol., 104, 267, 10.1097/01.AOG.0000134783.98382.b0

Ferris, 2004, Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis, BMC Infect. Dis., 4, 5, 10.1186/1471-2334-4-5

Burton, 2004, Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation, J. Clin. Microbiol., 42, 1829, 10.1128/JCM.42.4.1829-1831.2004

Wiesenfeld, 2003, Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection, Clin. Infect. Dis., 36, 663, 10.1086/367658

Kaul, 2001, New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workers, Immunol. Lett., 79, 3, 10.1016/S0165-2478(01)00260-7