Circulating tumor cells and miRNAs as prognostic markers in neuroendocrine neoplasms

Endocrine-Related Cancer - Tập 24 Số 6 - Trang R223-R237 - 2017
Maria Chiara Zatelli1, Erika Grossrubatscher2, Elia Guadagno3, Concetta Sciammarella4, Antongiulio Faggiano5, Annamaria Colao4
1Department of Medical Sciences, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy
2Endocrine Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
3Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy
4IOS & COLEMAN Srl, Naples, Italy
5Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”-IRCCS, Naples, Italy

Tóm tắt

The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. This review summarizes the available data on the possible role of circulating tumor cells and microRNAs as prognostic markers in NENs.

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Tài liệu tham khảo

10.1158/1078-0432.CCR-11-0242

10.1007/978-3-642-28160-0_6

10.1373/clinchem.2012.194258

10.1128/JCM.39.2.485-493.2001

10.1073/pnas.1019055108

Bethel, 2014, Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction., Physical Biology, 11, 016002, 10.1088/1478-3975/11/1/016002

10.1371/journal.pone.0091388

10.1007/s10555-012-9398-0

Blom, 2014, Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma, Journal of the American Academy of Dermatology, 70, 449, 10.1016/j.jaad.2013.10.051

10.1261/rna.5167604

Borchert, 2006, RNA polymerase III transcribes human microRNAs, Nature Structural and Molecular Biology, 13, 1097, 10.1038/nsmb1167

10.1158/0008-5472.CAN-12-3055

Cao, 2016, A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms, Oncotarget, 7, 42045, 10.18632/oncotarget.9805

Capdevila, 2014, Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets, Cancer and Metastasis Reviews, 33, 345, 10.1007/s10555-013-9468-y

Carter, 2017, Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer, Nature Medicine, 23, 114, 10.1038/nm.4239

Chen, 2015, Single-cell analyses of circulating tumor cells, Cancer Biology and Medicine, 12, 184

Chen, 2015, The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer, International Journal of Clinical and Experimental Pathology, 8, 7092

10.1038/nature03868

10.1200/JCO.2007.15.8923

10.1093/annonc/mdn786

10.1056/NEJMoa040766

10.1158/1078-0432.CCR-07-1506

10.1158/1078-0432.CCR-08-0872

10.1530/ERC-12-0183

Deng, 2014, Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA, Cell and Bioscience, 4, 35, 10.1186/2045-3701-4-35

Di Leva, 2014, MicroRNAs in cancer, Annual Review of Pathology, 9, 287, 10.1146/annurev-pathol-012513-104715

Dive C Brady G 2017 SnapShot: circulating tumor cells. Cell 168 742–742.e1. (doi:10.1016/j.cell.2017.01.026)

Dossing, 2014, Down-regulation of miR-129-5p and the let-7 family in neuroendocrine tumors and metastases leads to up-regulation of their targets Egr1, G3bp1, Hmga2 and Bach1, Genes, 6, 1, 10.3390/genes6010001

Fabisiewicz, 2017, CTC clusters in cancer progression and metastasis, Medical Oncology, 34, 12, 10.1007/s12032-016-0875-0

10.1093/jnci/45.4.773

Gaiser, 2015, Evaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers, Oncotarget, 6, 26472, 10.18632/oncotarget.4500

Gao, 2016, Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization, Journal of Experimental and Clinical Cancer Research, 35, 66, 10.1186/s13046-016-0340-0

Gundara, 2014, Nodal metastasis microRNA expression correlates with the primary tumour in MTC, ANZ Journal of Surgery, 84, 235, 10.1111/j.1445-2197.2012.06291.x

10.1101/gad.1262504

10.1038/bjc.2013.448

10.1200/JCO.2007.14.2364

10.1038/nrg1379

10.1634/theoncologist.2010-0103

10.1093/annonc/mds138

10.1007/s004080000091

10.1093/carcin/bgs030

10.1016/j.eururo.2014.07.035

10.1016/j.yexmp.2013.05.001

Jansen, 2004, Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity, Molecular Cancer Therapeutics, 3, 103, 10.1158/1535-7163.103.3.2

10.2967/jnumed.116.174714

Joosse, 2014, Circulating cell-free cancer-testis MAGE-A RNA, BORIS RNA, let-7b and miR-202 in the blood of patients with breast cancer and benign breast diseases, British Journal of Cancer, 111, 909, 10.1038/bjc.2014.360

10.1002/cncr.26565

10.1158/1078-0432.CCR-10-1776

10.1200/JCO.2012.44.2905

10.1158/1078-0432.CCR-15-1008

10.1016/j.tcb.2004.02.006

10.1038/nrm1644

10.1038/nrm2632

10.1158/1078-0432.CCR-14-2011

10.1200/JCO.2010.28.7045

10.1016/S0969-8051(03)00058-1

10.1126/science.1064921

10.1186/gb-2003-4-7-r42

10.1002/ijc.26031

Larrea E Sole C Manterola L Goicoechea I Armesto M Arestin M Caffarel MM Araujo AM Araiz M Fernandez-Mercado M 2016 New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies. International Journal of Molecular Sciences 17 E627. (doi:10.3390/ijms17050627)

Lassalle, 2016, MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib, Oncotarget, 7, 30461, 10.18632/oncotarget.8458

10.1373/clinchem.2009.131797

10.1126/science.1065062

Lee, 1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75, 886, 10.1016/0092-8674(93)90529-Y

Lee, 2002, MicroRNA maturation: stepwise processing and subcellular localization, EMBO Journal, 21, 843, 10.1093/emboj/cdf476

Lee, 2004, MicroRNA genes are transcribed by RNA polymerase II, EMBO Journal, 23, 522, 10.1038/sj.emboj.7600385

10.1038/sj.emboj.7600902

10.1371/journal.pone.0021300

10.1111/j.1440-1827.2012.02845.x

Lee, 2015, High expression of microRNA-196a indicates poor prognosis in resected pancreatic neuroendocrine tumor, Medicine, 94, e2224, 10.1097/MD.0000000000002224

Li, 2013, MicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with low-stage pancreatic cancer from healthy and disease controls, Clinical Cancer Research, 19, 4663, 10.1158/1078-0432.CCR-12-3092

Li, 2013, Global microRNA profiling of well-differentiated small intestinal neuroendocrine tumors, Modern Pathology, 26, 4051, 10.1038/modpathol.2012.216

10.1371/journal.pone.0125553

Liu, 2015, miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1, International Journal of Experimental Pathology, 96, 3600, 10.1111/iep.12131

Mairinger, 2014, Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study, Modern Pathology, 27, 685, 10.1038/modpathol.2014.74

Mancuso, 2016, Prognostic impact of a 3-MicroRNA signature in cytological samples of small cell lung cancer, Cancer Cytopathology, 124, 240, 10.1002/cncy.21729

Mathew, 2015, Can circulating tumor cells predict resistance in metastatic breast cancer?, Clinical Cancer Research, 21, 1632, 10.1158/1078-0432.CCR-14-2967

Matthaei, 2012, miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts, Clinical Cancer Research, 18, 621, 10.1158/1078-0432.CCR-12-0035

McDonald, 2011, Analysis of circulating microRNA: preanalytical and analytical challenges, Clinical Chemistry, 57, 2421, 10.1373/clinchem.2010.157198

Meyer-Rochow, 2010, MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets, Endocrine-Related Cancer, 17, 4713, 10.1677/ERC-10-0142

Mian, 2012, MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome, Thyroid, 22, 833, 10.1089/thy.2012.0045

10.1371/journal.pone.0124245

Miller, 2016, MicroRNAs associated with small bowel neuroendocrine tumours and their metastases, Endocrine-Related Cancer, 23, 835, 10.1530/ERC-16-0044

Mohammadian, 2013, Normalization of miRNA qPCR high-throughput data: a comparison of methods, Biotechnology Letters, 35, 890, 10.1007/s10529-013-1150-5

Nikiforova, 2008, MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility, Journal of Clinical Endocrinology and Metabolism, 93, 711, 10.1210/jc.2007-2696

Nuovo, 2010, In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets, Methods, 52, 843, 10.1016/j.ymeth.2010.08.009

Oberg, 2015, Consensus on biomarkers for neuroendocrine tumour disease, Lancet Oncology, 16, e1600, 10.1016/S1470-2045(15)00186-2

Olmos, 2009, Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience, Annals of Oncology, 20, 307, 10.1093/annonc/mdn544

10.1007/s00432-007-0248-3

Parkinson, 2012, Considerations in the development of circulating tumor cell technology for clinical use, Journal of Translational Medicine, 10, 138, 10.1186/1479-5876-10-138

10.1530/ERC-11-0306

Pennelli, 2015, The PDCD4/miR-21 pathway in medullary thyroid carcinoma, Human Pathology, 46, 27, 10.1016/j.humpath.2014.09.006

Ranade, 2010, MicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancer, Journal of Thoracic Oncology, 5, 157, 10.1097/JTO.0b013e3181dea6be

Rapa, 2015, Identification of microRNAs differentially expressed in lung carcinoid subtypes and progression, Neuroendocrinology, 101, 50, 10.1159/000381454

10.1200/JCO.2005.04.7522

10.1186/bcr2766

Ruebel, 2010, MicroRNA expression in ileal carcinoid tumors: downregulation of microRNA-133a with tumor progression, Modern Pathology, 23, 246, 10.1038/modpathol.2009.161

Ruzzenente, 2016, A novel nomogram to predict the prognosis of patients undergoing liver resection for neuroendocrine liver metastasis: an analysis of the Italian neuroendocrine liver metastasis database, Journal of Gastrointestinal Surgery, 21, 4677

Santarpia, 2013, A miRNA signature associated with human metastatic medullary thyroid carcinoma, Endocrine-Related Cancer, 20, 367, 10.1530/ERC-13-0357

Saucedo-Zeni, 2012, A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire, International Journal of Oncology, 41, 41

Sieuwerts, 2009, Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR, Breast Cancer Research and Treatment, 118, 809, 10.1007/s10549-008-0290-0

Smerage, 2014, Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500, Journal of Clinical Oncology, 32, 1241, 10.1200/JCO.2014.56.2561

Tang, 2005, siRNA and miRNA: an insight into RISCs, Trends in Biochemical Sciences, 30, 455, 10.1016/j.tibs.2004.12.007

Thiery, 2002, Epithelial-mesenchymal transitions in tumour progression, Nature Reviews Cancer, 2, 3483, 10.1038/nrc822

Thorns, 2014, Global microRNA profiling of pancreatic neuroendocrine neoplasias, Anticancer Research, 34, 106

Tombol, 2010, MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas, Modern Pathology, 23, 442, 10.1038/modpathol.2010.164

Ushiku, 2016, Homeobox-only protein expression is a critical prognostic indicator of pancreatic neuroendocrine tumor and is regulated by promoter DNA hypermethylation, Pancreas, 45, 1255, 10.1097/MPA.0000000000000646

Uso, 2014, miRNA detection methods and clinical implications in lung cancer, Future Oncology, 10, 2249, 10.2217/fon.14.93

Valadi, 2007, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nature Cell Biology, 9, 1583, 10.1038/ncb1596

Verbeek, 2016, GEP-NETs UPDATE: secreting gastro-enteropancreatic neuroendocrine tumours and biomarkers, European Journal of Endocrinology, 174, R2279, 10.1530/EJE-14-0971

Vicentini, 2014, Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract, Molecules, 19, 654, 10.3390/molecules19022458

10.1038/ncb2246

Villani, 2016, Phosphorylated histone H3 (PHH3) is a superior proliferation marker for prognosis of pancreatic neuroendocrine tumors, Annals of Surgical Oncology, 23, 2458, 10.1245/s10434-016-5171-x

Wang, 2016, Promise and limits of the CellSearch platform for evaluating pharmacodynamics in circulating tumor cells, Seminars in Oncology, 43, 609, 10.1053/j.seminoncol.2016.06.004

Wang, 2017, Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion, Oncotarget, 8, 423

Watson, 2012, Do platform-specific factors explain microRNA profiling disparities?, Clinical Chemistry, 58, 464, 10.1373/clinchem.2011.175281

10.5732/cjc.010.10522

Wu Q Lu Z Li H Lu J Guo L Ge Q 2011 Next-generation sequencing of microRNAs for breast cancer detection. Journal of Biomedicine and Biotechnology 2011 597145. (doi:10.1155/2011/597145)

Xi, 2007, Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples, RNA, 13, 472, 10.1261/rna.642907

Yanagita, 2016, A prospective evaluation of circulating tumor cells and cell-free DNA in EGFR mutant non-small cell lung cancer patients treated with erlotinib on a phase II trial, Clinical Cancer Research, 22, 474, 10.1158/1078-0432.CCR-16-0909

10.1093/nar/gkl110

Zhang, 2012, Meta-analysis of the prognostic value of circulating tumor cells in breast cancer, Clinical Cancer Research, 18, 6010, 10.1158/1078-0432.CCR-12-1587

Zhao, 2016, Clinical significance of circulating miRNA detection in lung cancer., Medical Oncology, 33, 41, 10.1007/s12032-016-0757-5

Zheng, 2011, Plasma microRNAs as novel biomarkers for early detection of lung cancer, International Journal of Clinical and Experimental Pathology, 4, 575

Zong, 2015, Role of miR-101 in pheochromocytoma patients with SDHD mutation, International Journal of Clinical and Experimental Pathology, 8, 4622