Childhood exposure to violence and lifelong health: Clinical intervention science and stress-biology research join forces

Development and Psychopathology - Tập 25 Số 4pt2 - Trang 1619-1634 - 2013
Terrie E. Moffitt1,2
1Duke University
2King's College London

Tóm tắt

Abstract

Many young people who are mistreated by an adult, victimized by bullies, criminally assaulted, or who witness domestic violence react to this violence exposure by developing behavioral, emotional, or learning problems. What is less well known is that adverse experiences like violence exposure can lead to hidden physical alterations inside a child's body, alterations that may have adverse effects on life-long health. We discuss why this is important for the field of developmental psychopathology and for society, and we recommend that stress-biology research and intervention science join forces to tackle the problem. We examine the evidence base in relation to stress-sensitive measures for the body (inflammatory reactions, telomere erosion, epigenetic methylation, and gene expression) and brain (mental disorders, neuroimaging, and neuropsychological testing). We also review promising interventions for families, couples, and children that have been designed to reduce the effects of childhood violence exposure. We invite intervention scientists and stress-biology researchers to collaborate in adding stress-biology measures to randomized clinical trials of interventions intended to reduce effects of violence exposure and other traumas on young people.

Từ khóa


Tài liệu tham khảo

10.1016/j.biopsych.2009.02.034

2001, The World Health Report 2001—Mental health: New understanding, new hope

10.1002/hipo.20437

10.4161/epi.5.6.12226

10.1038/embor.2011.166

10.1016/j.jaac.2012.01.001

10.1016/j.amepre.2008.06.024

10.1038/nn1276

10.1176/appi.ajp.159.12.2072

10.1093/schbul/sbs050

10.1016/j.amepre.2009.11.012

Tough P. (2011, March 21) The poverty clinic: Can a stressful childhood make you sick? New Yorker. Retrieved from http://www.newyorker.com/reporting/2011/03/21/110321fa_fact_tough

10.1016/j.jaac.2011.03.002

Thurmaier, 1999, Eheglück auf Dauer? Methodik, Inhalte und Effektivität eines präventiven Paarkommunikationstrainings. Ergebnisse nach 5 Jahren [Marital satisfaction forever? Method, content, and effectiveness of a prevention intervention. 5-year results], Zeitschrift für Klinische Psychologie, 28, 64

Thomaes, 2012, Treatment effects on insular and anterior cingulate cortex activation during classic and emotional Stroop interference in child abuse-related complex post-traumatic stress disorder, Psychological Medicine, 22, 1

10.2105/AJPH.2007.126722

10.1207/S15327558IJBM1003_05

10.1016/j.jnutbio.2009.11.012

Soczynska J. K. , Zhang L. , Kennedy S. H. , & McIntyre R. S. (2012), Are psychiatric disorders inflammatory-based conditions? Psychiatric Times. Advance online publication.

10.1097/PSY.0b013e3181e9c16f

10.1016/j.biopsych.2006.02.004

10.1073/pnas.1121259109

10.1073/pnas.0806660106

Shalev, 2012, Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: A longitudinal study, Molecular Psychiatry

10.1038/sj.mp.4001636

10.1037/0022-3514.86.1.162

10.1097/00004583-199502000-00014

10.3109/10253899609001092

10.1056/NEJM199901143400207

10.1002/jts.20622

10.1186/1471-2458-5-7

10.1017/S0954579405050352

10.1038/nature09230

10.1111/1469-7610.00612

10.1016/0145-2134(94)90012-4

10.1177/1468017309350663

10.1023/A:1024958332093

10.1016/j.biopsych.2011.01.035

10.1038/nrn752

10.1001/archpsyc.59.2.139

10.1097/PSY.0b013e318190d7de

10.1016/j.biopsych.2008.03.017

10.1038/nrd3628

10.1016/j.cpr.2009.06.008

10.1146/annurev-clinpsy-032210-104601

10.1038/nn.2270

10.1001/jama.290.17.2320

10.1073/pnas.1121254109

10.1111/j.1469-7610.2010.02271.x

10.1037/0022-006X.61.1.70

10.1016/S0140-6736(08)61708-0

10.1001/archgenpsychiatry.2011.2287

Krug, 2002, World report on violence and health, 10.1016/S0140-6736(02)11133-0

10.1016/j.jbtep.2011.02.002

10.1097/PSY.0b013e31820573b6

10.1001/archpsyc.57.10.953

10.1371/journal.pone.0010826

10.1126/science.330.6004.576

10.1037/a0019281

10.1038/nature09603

10.1016/j.mehy.2004.11.014

10.1016/j.chiabu.2006.03.011

10.4161/epi.4.8.10265

10.1093/ije/dyr225

10.3389/fnhum.2012.00052

10.1037/0893-3200.12.4.543

Hahlweg, 2010, Enhancing couples: The shape of couple therapy to come, 3

10.1037/0022-3514.86.1.174

10.1002/ajhb.20590

10.1016/S0140-6736(08)61707-9

O'Connell, 2009, Preventing mental, emotional, and behavioral disorders among young people: Progress and possibilities, 157

10.1073/pnas.0500398102

10.1086/504729

10.1136/bmj.e2683

10.1016/j.chiabu.2008.09.012

Finkelhor, 1997, Sexueller Missbrauch. Überblick zu Forschung, Beratung und Therapie. Ein Handbuch, 72

10.18632/aging.100007

10.1073/pnas.0407162101

10.1001/archpediatrics.2011.565

10.1038/mp.2011.53

10.1016/j.amjcard.2010.04.018

10.1002/da.20744

10.1037/0022-3514.86.1.130

10.1186/gb-2012-13-6-r43

10.1016/j.psyneuen.2011.10.008

10.1038/nrn2297

10.1016/j.biopsych.2011.10.021

10.1073/pnas.1218253109

Cicchetti, 2005, Annual review of clinical psychology, 1, 409

10.1017/S0954579406060329

10.1002/cd.242

10.1111/j.1469-7610.2012.02608.x

10.1038/mp.2010.53

10.1016/j.neubiorev.2007.10.009

10.1016/j.conb.2005.10.001

10.1037/0022-006X.72.3.500

10.1037/a0021227

10.1016/S0140-6736(03)12384-7

Carrion V. G. , & Kletter H. (2102). Treatment of traumatic stress disorder in children and adolescents: Assessment and treatment strategies. Psychiatric Times, 29. Advance online publication.

10.1023/A:1025006909538

10.1016/j.biopsych.2011.05.006

10.4161/epi.7.1.18688

10.1371/journal.pone.0014821

10.1002/ajmg.b.31028

Barker, 1992, Fetal and infant origins of adult disease

10.1093/aje/kwn338

10.1111/j.1469-7610.2004.00351.x

10.1176/jnp.2008.20.3.292

10.1146/annurev.psych.60.110707.163551

10.1016/j.psyneuen.2010.09.010

10.1093/schbul/sbp104

10.1037/0021-843X.115.3.484

10.1016/j.biopsych.2005.12.016

10.1111/j.1467-9280.2007.01860.x

10.1038/nrn2639

10.1007/s10802-011-9566-7

10.2105/AJPH.88.1.15

10.1016/j.biopsych.2008.11.029

10.1210/jc.2010-2924

10.1097/00004583-200011000-00009

10.1001/archgenpsychiatry.2009.186

2006, Ageing: Can we stop the clock?

10.1017/S0033291709991383

10.1523/JNEUROSCI.0859-10.2010

10.1016/S0140-6736(08)61706-7

10.1037/0278-6133.20.1.47

10.1002/ajmg.b.31212

10.1097/PSY.0b013e3181cb9377

10.1073/pnas.0910794107

10.1192/bjp.bp.111.103267

10.1038/nature07201

10.1038/nbt1010-1049

10.1542/peds.2009-0467

10.1038/oby.2008.413

10.1016/j.chiabu.2006.03.012

10.1038/nature05485

10.1016/j.physbeh.2011.08.019

10.1038/sj.mp.4001950

10.1017/S0954579408000400

10.1017/S0954579411000411

Yu, 2008, Short telomeres in patients with chronic schizophrenia who show a poor response to treatment, Journal of Psychiatry Neuroscience, 33, 244

10.2471/BLT.08.057075

Cummings, 2010, Marital conflict and children. An emotional security perspective

10.1093/ije/dyp273

10.1016/j.cpr.2005.09.005

10.1016/j.psyneuen.2012.05.019

10.1037/0022-006X.56.2.210

10.1016/j.avb.2010.12.007

10.1001/archpsyc.65.4.409

10.1155/2011/560572

10.1017/S0954579405050315

10.1016/j.chiabu.2013.02.004

10.1155/2011/328054

Bodenmann, 2004, Verhaltenstherapie mit Paaren

10.1093/schbul/sbs074

10.1111/j.1600-0447.2008.01246.x

10.1073/pnas.1121264109

10.1038/nature07206

10.1073/pnas.1113306109

10.1146/annurev.psych.58.110405.085605

10.1192/bjp.bp.110.080499

10.1001/jama.284.5.592

10.1016/S0140-6736(05)66630-5

10.1146/annurev.psych.57.102904.190205

10.1016/j.chiabu.2009.12.003

10.1196/annals.1364.024

10.1371/journal.pgen.1000602

10.1016/j.biopsych.2006.04.035

10.1016/j.biopsych.2009.08.014

10.1016/j.chiabu.2007.12.006

10.1001/jama.279.18.1477

10.1111/j.1469-7610.2010.02304.x

10.1001/jama.299.24.2877

10.1038/nature08984

10.1016/j.cpr.2010.07.004

10.1007/s11121-009-0123-3

10.1073/pnas.0610362104

10.1038/nn.3093

10.1017/S0954579408000357

10.4088/JCP.10m06745

10.1542/peds.2011-2663

10.1016/j.brat.2012.01.001

10.1093/schbul/sbs088

10.1017/S0954579403000166

10.1017/CBO9780511777042.003

10.1176/appi.ajp.2010.10040567

10.1038/mp.2010.5

10.1371/journal.pone.0030148

10.1146/annurev-nutr-071811-150726

10.1016/j.biopsych.2010.02.026

10.1037/e587022010-001

10.2105/AJPH.2011.300636

10.1037/a0024768

10.1097/PSY.0b013e3181907c1b

10.1111/j.1545-5300.2009.01299.x

10.1176/appi.ajp.2011.11020335

10.1017/S0954579411000307

10.1016/S0006-3223(02)01459-2

10.1196/annals.1393.013