Chemoresistance to Temozolomide in Human Glioma Cell Line U251 is Associated with Increased Activity of O 6-methylguanine-DNA Methyltransferase and Can be Overcome by Metronomic Temozolomide Regimen

Qiang Pan1,2, Xuejun Yang1, Huamin Wang2,1, Xuetao Dong2,1, Wei Wang2,1, Yu Li2,1, Jingmin Li3
1Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, People’s Republic of China
2Neuro-Oncology Laboratory, Tianjin Neurological Institute, Tianjin, People’s Republic of China
3Institute of Human Anatomy and Embryology, Bin Zhou Medical College, Bin Zhou, People’s Republic of China

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