Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer

Schubert SY, Lansky EP, Neeman I: Antioxidant and eiocsanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol 66: 11–17, 1999

Heftmann E, Ko ST, Bennet RD: Identification of estrone in pomegranate seeds. Phytochem 5: 1337–1340, 1966

Anesini C, Perez C: Screening of plants used in Argentine folk medicine for antimicrobial activity. J Ethnopharmacol 39: 119–128, 1993

Ponce-Macotela M, Navarro-Alegria I, Martinez-Gordillo MN, Alvarez-Chacon R: [In vitro effect against Giardia of 14 plant extracts]. Rev Invest Clin 46: 343–347, 1994

Zhanag J, Zhan B, Yao X, Gao Y, Shong J: [Antiviral activity of tannin from the pericarp of Punica granatum L against Herpes virus in vitro]. Chung Kuo Chung Yao Tsa Chih 20: 556–558, 1995

Mavlyanov SM, Islambekov SY, Karimdzhanov AK, Ismailov AI: [Polyphenols of pomegranate peels show marked antitumor and anti-viral action.] Khim Prir Soedin 33: 124–126, 1997

Jafri MA, Aslam M, Javed K, Singh S: Effect of Punica granatum Linn (flowers) on blood glucose level in normal and alloxan-induced diabetic rats. J Ethnopharmacol 70: 309–314, 2000

Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, Hayek T, Presser D, Fuhrman B: Pomegranate juice consumption reduces oxidative stress, atherogenic modi-fications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 71: 1062–1076, 2000

Artik N, Cemeroglu B, Murakami H, Mori T: Determination of phenolic compounds in pomegranate juice by HPLC. Fruit Process 8: 492–499, 1998

Ben Nasr N, Ayed M: Quantitative determination of the polyphenolic content of pomegranate peel. Z Lebensm Unters Forsch 203: 374–378, 1996

Caltagirone S, Rossi C, Poggi A, Ranalletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli, M: Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 87: 595–600, 2000

Yang K, Lamprecht SA, Liu Y, Shinozaki H, Fan K, Leung D, Newmark H, Steele VE, Kelloff GJ, Lipkin M: Chemopreventions studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon. Carcinogenesis 21: 1655–1660, 2000

Koide T, Kamei H, Hashimoto Y, Kojima T, Hasegawa M: Tannic acid raises survival rate of mice bearing syngeneic tumors. Cancer Biother Radiopharm 4: 231–234, 1999

Wang CC, Chen LG, Yang LL: Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia. Cancer Lett 140: 195–200, 1999

Yang LL, Lee CY, Yen KY: Induction of apoptosis by hydrolyzable tannins from Eugenia jambos L. on human leukemia cells. Cancer Lett 157: 65–75, 2000

Igarshi M, Miyazawa T: Newly recognized cytotoxic effect of conjugated trienoic fatty acids on cultured human tumor cells. Cancer Lett 48: 173–179, 2000

O'shea M, Stanton C, Devery R: Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. Anticancer Res 19: 1953–1959, 1999

Pariza M: References on conjugated linoleic acic research. www.wisc.edu/fri/clarefs.htm.

Lansky E, Livney T, Neeman I, Amichay A: Unpublished data (2000).

Rosenberg Zand RS, Jenkins DJA, Diamandis EP: Steroid hormone activity of flavonoids and related compounds. Breast Cancer Res Treat 62: 35–49, 2000

Moneam NMA, El Sharaky AS, Badreldin MM: Oestrogen content of pomegranate seeds. J Chromatograp 438: 438–442, 1988

Abd El Wahab SM, El Fiki NM, Mostafa SF, Hassan AEB: Characterization of certain steroid hormones in Punica granatum L. seeds. Bull Facult Pharm (Cairo University) 36: 11–15, 1998

Collins BM, McLachlan JA, Arnold SF: The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. Steroids 62: 365–372, 1997

Andersen HR, Andersson AM, Arnold SF, Autrup H, Barfoed M, Beresford NA, Bjerregaard P, Christiansen LB, Gissel B, Hummel R, Jorgensen EB, Korsgaard B, Le Guevel R, Leffers H, McLachlan J, Moller A, Nielsen JB, Olea N, Oles-Karasko A, Pakdel F, Pedersen KL, Perez P, Skakkeboek NE, Sonnenschein C, Soto AM, Sumpter JP, Thorpe SM, Grandjean P: Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ Health Perspect 107: 89–108, 1999

Luu-The V, Zhang Y, Poirier D, Labrie F: Characteristics of human types 1, 2 and 3 17-beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition. J Steroid Biochem Molec Biol 55: 581–587, 1995

Tremblay MR, Poirier D: Overview of a rational approach to design type I 17beta-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation. J Steroid Biochem Mol Biol 66: 179–191, 1998

Tada H, Shiho O, Kuroshima K, Tsukamoto K: An improved colorimetric assay for interleukin 2. J Immunol Meth 93: 157–165, 1986

Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN: A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239–3245, 1987

Jiang WG, Hiscox S, Hallett MB, Horrobin DF, Mansel RE, Puntis MCA: Regulation of the expression of E-cadherin on human cancer cells by gamma linolenic acid. Cancer Res 55: 5043–5048, 1995

Zhang RD, Fidler IJ, Price JE: Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metast 11: 204–215, 1991

Yu W, Israel K, Liao QY, Aldaz CM, Sanders BG, Kline K: Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res 9: 953–961, 1999

Mehta RG, Steele V, Kelloff GJ, Moon C: Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro. Anticancer Res 11: 587–592, 1991

Mehta RG: Experimental basis for the prevention of breast cancer. Eur J Cancer 36: 1275–1282, 2000

Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kader AA: Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48: 4581–4589, 2000

Alshafie GA, Abou-Issa HM, Seibert K, Harris RE: Chemotherapeutic evaluation of celecob, a cyclooxygenase-2 inhibitor, in a rat mammary tumor model. Oncol Rep 7: 1377–1381, 2000

Trimboli AJ, Waite BM, Atsumi G, Fonteh AN, Namen AM, Clay CE, Kute TE, High KP, Willingham MC, Chilton FH: Influence of conezyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells. Cancer Res 59: 6171–6177, 1999

Matsumoto-Taniura N, Matsumoto K, Nakamura T: Prostaglandin production in mouse mammary tumour cells confers invasive growth potential by inducing hepatocyte growth factor in stromal fibroblasts. Br J Cancer 81: 194–202, 1999

Jang M, Udeani G, Sowing-Barillas K, Thomas C, Beecher CWW, Fong H, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto J: Cancer chemopreventive activity of resveretrol, a component of the human diet derived from Vitis vinifera (the grape). Science 275: 218–220, 1997

Bracke ME, Depypere HT, Boterberg T, Van Marck VL, Vennekens KM, Vanluchene E, Nuytinck M, Serreyn R, Mareel MM: Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. J Natl Cancer Inst 91: 354–359, 1999

Nepka C, Asprodini E, Kouretas D: Tannins, xenobiotic metabolism and cancer chemoprevention in experimental animals. Eur J Drug Metab Pharmacokinet 24: 183–189, 1999

Tanaka T, Kojima T, Kawamori T, Yoshimi N, Mori H: Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats. Cancer Res 53: 2775–2779, 1993

Meiers S, Kemeny M, Weyand U, Gastpar R, von Angerer E, Marko D: The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J Agric Food Chem 49: 958–962, 2001

Yu W, Simmons-Menchaca M, Gapor A, Sanders BG, Kline K: Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer 33: 26–32, 1999

Awad AB, Fink CS: Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr 130: 2127–2130, 2000

Dixon-Shanies D, Shaikh N: Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep 6: 1383–1397, 1999

Nugteren DH, Christ-Hazelhof E: Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesis. Prostaglandins 33: 403–417, 1987

Ip C, Ip MM, Loftus T, Shoemaker S, Shea-Eaton W: Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland. Cancer Epidemiol Biomark Prev 9: 689–696, 2000

Khayat D, Gil-Delgado M, Antoine EC, Nizri D, Bastian G: The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer. Oncology (Huntingt) 15: 415–429, discussion 429–430, 433–434, 2001

Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K: Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA 97: 1433–1437, 2000