Chemical synthesis of MnFe2O4/chitosan nanocomposites for controlled release of ofloxacin drug

Journal of the Chinese Chemical Society - Tập 66 Số 6 - Trang 600-607 - 2019
Ayoub Moghadam1
1Department of Materials Science & Engineering Razi University Kermanshah Iran

Tóm tắt

In this study, we synthesized ofloxacin‐loaded MnFe2O4 nanoparticles (NPs) surface modified with chitosan (CS‐MnFe2O4) for prolonged antibiotic release in a controlled manner. It was found that the synthesized CS‐MnFe2O4 was spherical in shape with an average size of 30–50 nm, low aggregation, and good magnetic responsibility. An in vitro drug loading and release kinetics study reveals that the drug delivery system can take 86% of drug load and can release ofloxacin over a sustained period of 3 days. The release kinetics study reveals that the drug follows zero order kinetics and the mechanism of drug release is diffusion‐controlled type. These results indicated that CS‐MnFe2O4 NPs with pH‐sensitive properties can be used as candidates for intestinal targeted drug delivery through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach.

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Journal of the Chinese Chemical Society

Tập 66 Số 6

600-607

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