Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Brugarolas, 1997, Double indemnity, Nat. Med, 3, 721, 10.1038/nm0797-721

Chapman, 1996, Transcriptional activation by BRCA1, Nature, 382, 678, 10.1038/382678a0

Chen, 1996, BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner, Cancer Res, 56, 3168

Chen, 1998, Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells, Mol. Cell, 2, 317, 10.1016/S1097-2765(00)80276-2

Crook, 1997, p53 mutations in BRCA1-associated familial breast cancer, Lancet, 350, 638, 10.1016/S0140-6736(05)63327-2

Deng, 1995, Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control, Cell, 82, 675, 10.1016/0092-8674(95)90039-X

Fukasawa, 1996, Abnormal centrosome amplification in the absence of p53, Science, 271, 1744, 10.1126/science.271.5256.1744

Gowen, 1996, Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities, Nat. Genet, 12, 191, 10.1038/ng0296-191

Gowen, 1998, BRCA1 required for transcription-coupled repair of oxidative DNA damage, Science, 281, 1009, 10.1126/science.281.5379.1009

Hakem, 1996, The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse, Cell, 85, 1009, 10.1016/S0092-8674(00)81302-1

Hakem, 1997, Partial rescue of Brca1 (5–6) early embryonic lethality by p53 or p21 null mutation, Nat. Genet, 16, 298, 10.1038/ng0797-298

Hsu, 1998, BRCA1 is associated with the centrosome during mitosis, Proc. Natl. Acad. Sci. USA, 95, 12983, 10.1073/pnas.95.22.12983

Kinzler, 1997, Cancer-susceptibility genes. Gatekeepers and caretakers, Nature, 386, 761, 10.1038/386761a0

Lane, 1995, Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice, Genes Dev, 9, 2712, 10.1101/gad.9.21.2712

Larson, 1997, A BRCA1 mutant alters G2–M cell cycle control in human mammary epithelial cells, Cancer Res, 57, 3351

Lim, 1996, A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53, Mol. Cell. Biol, 16, 7133, 10.1128/MCB.16.12.7133

Lingle, 1998, Centrosome hypertrophy in human breast tumors, Proc. Natl. Acad. Sci. USA, 95, 2950, 10.1073/pnas.95.6.2950

Linke, 1997, p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation, Cancer Res, 57, 1171

Liu, 1996, Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development, Genes Dev, 10, 1835, 10.1101/gad.10.14.1835

Liyanage, 1996, Multicolour spectral karyotyping of mouse chromosomes, Nat. Genet, 14, 312, 10.1038/ng1196-312

Ludwig, 1997, Targeted mutations of breast cancer susceptibility gene homologs in mice, Genes Dev, 11, 1226, 10.1101/gad.11.10.1226

Meyn, 1997, Chromosome instability syndromes, Curr. Top. Microbiol. Immunol, 221, 71

Morgan, 1997, p53 and ATM, Adv. Cancer Res, 71, 1, 10.1016/S0065-230X(08)60095-0

Ogawa, 1993, RecA-like recombination proteins in eukaryotes, Cold Spring Harb. Symp. Quant. Biol, 58, 567, 10.1101/SQB.1993.058.01.063

Patel, 1998, Involvement of Brca2 in DNA repair, Mol. Cell, 1, 347, 10.1016/S1097-2765(00)80035-0

Paterson, 1998, BRCA1, Dis. Markers, 13, 261, 10.1155/1998/298530

Pihan, 1998, Centrosome defects and genetic instability in malignant tumors, Cancer Res, 58, 3974

Rudner, 1996, The spindle assembly checkpoint, Curr. Opin. Cell Biol, 8, 773, 10.1016/S0955-0674(96)80077-9

Ruffner, 1997, BRCA1 is a cell cycle-regulated nuclear phosphoprotein, Proc. Natl. Acad. Sci. USA, 94, 7138, 10.1073/pnas.94.14.7138

Scully, 1997, Association of BRCA1 with Rad51 in mitotic and meiotic cells, Cell, 88, 265, 10.1016/S0092-8674(00)81847-4

Scully, 1997, Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage, Cell, 90, 425, 10.1016/S0092-8674(00)80503-6

Sharan, 1997, Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2, Nature, 386, 804, 10.1038/386804a0

Shen, 1998, A targeted disruption of the murine Brca1 gene causes γ-radiation hypersensitivity and genetic instability, Oncogene, 17, 3115, 10.1038/sj.onc.1202243

Somasundaram, 1997, Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1, Nature, 389, 187, 10.1038/38291

Struewing, 1997, The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews, N. Engl. J. Med, 336, 1401, 10.1056/NEJM199705153362001

Tirkkonen, 1997, Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations, Cancer Res, 57, 1222

Tomlinson, 1998, Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier, Cancer Res, 58, 3237

Tseng, 1997, Allelic loss at BRCA1, BRCA2, and adjacent loci in relation to TP53 abnormality in breast cancer, Genes Chromosomes Cancer, 20, 377, 10.1002/(SICI)1098-2264(199712)20:4<377::AID-GCC9>3.0.CO;2-Z

Vaughn, 1996, BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells, Cell Growth Differ, 7, 711

Wang, 1997, BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases, Oncogene, 15, 143, 10.1038/sj.onc.1201252

Weinert, 1998, DNA damage and checkpoint pathways, Cell, 94, 555, 10.1016/S0092-8674(00)81597-4

Winey, 1996, Keeping the centrosome cycle on track. Genome stability, Curr. Biol, 6, 962, 10.1016/S0960-9822(02)00639-5

Wu, 1996, Identification of a RING protein that can interact in vivo with the BRCA1 gene product, Nat. Genet, 14, 430, 10.1038/ng1296-430