Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27<sup>Kip1</sup> or p21<sup>Cip1</sup>
1Cancer Biology Research Center, Sanford Research/USD, 1400 West 22nd Street, Sioux Falls, South Dakota, 57105, USA
Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD 57197, USA