Sự tương tác giữa các tế bào trong viêm hoạt dịch: Tương tác giữa lymphocyte T và các tế bào hoạt dịch

Springer Science and Business Media LLC - Tập 2 - Trang 1-5 - 2000
Iain B McInnes1, Bernard P Leung1, Foo Y Liew1
1Centre for Rheumatic Diseases and Department of Immunology and Bacteriology, University of Glasgow, Glasgow, UK

Tóm tắt

Cơ chế mà lymphocyte T góp phần vào viêm màng hoạt dịch trong bệnh thấp khớp vẫn chưa được hiểu rõ. Trong bài viết này, chúng tôi xem xét dữ liệu cho thấy vai trò quan trọng của sự tiếp xúc giữa các tế bào T trong dịch khớp, các đại thực bào lân cận và các tế bào giống nguyên bào sợi (FLS). Do đó, các tế bào T được kích hoạt bởi cytokine, sự di chuyển của nội mô, ma trận ngoại bào hoặc bởi các kháng nguyên tự phát có thể thúc đẩy sản xuất cytokine, đặc biệt là TNFα, và metalloproteinase bởi các đại thực bào và FLS thông qua các tương tác màng tế bào, ít nhất được trung gian qua β-integrins và cytokine màng. Vì các yếu tố tan trong dịch do đó được kích thích có thể tiếp tục góp phần trực tiếp vào sự kích hoạt tế bào T, các vòng phản hồi tích cực có thể được tạo ra. Những con đường mới này đại diện cho những mục tiêu điều trị đầy hứa hẹn.

Từ khóa

#lymphocyte T #viêm hoạt dịch #cytokine #TNFα #metalloproteinase #đại thực bào #tương tác tế bào #phản hồi tích cực

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